Mark Brockman
Mark Brockman
Simon Fraser University and BC Centre for Excellence in HIV/AIDS
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Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction
DE Kaufmann, DG Kavanagh, F Pereyra, JJ Zaunders, EW Mackey, ...
Nature immunology 8 (11), 1246-1254, 2007
Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication
A Schneidewind, MA Brockman, R Yang, RI Adam, B Li, S Le Gall, ...
Journal of virology 81 (22), 12382-12393, 2007
HLA-B57/B* 5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T …
T Miura, MA Brockman, A Schneidewind, M Lobritz, F Pereyra, A Rathod, ...
Journal of virology 83 (6), 2743-2755, 2009
Escape and compensation from early HLA-B57-mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A
MA Brockman, A Schneidewind, M Lahaie, A Schmidt, T Miura, I DeSouza, ...
Journal of virology 81 (22), 12608-12618, 2007
IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells
MA Brockman, DS Kwon, DP Tighe, DF Pavlik, PC Rosato, J Sela, ...
Blood, The Journal of the American Society of Hematology 114 (2), 346-356, 2009
TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection
H Chen, ZM Ndhlovu, D Liu, LC Porter, JW Fang, S Darko, MA Brockman, ...
Nature immunology 13 (7), 691-700, 2012
Herpes simplex virus
TJ Taylor, MA Brockman, EE McNamee, DM Knipe
Front Biosci 7, d752-d764, 2002
HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins
ZL Brumme, M John, JM Carlson, CJ Brumme, D Chan, MA Brockman, ...
PloS one 4 (8), e6687, 2009
Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid
A Schneidewind, MA Brockman, J Sidney, YE Wang, H Chen, ...
Journal of virology 82 (11), 5594-5605, 2008
Responsiveness of HIV-specific CD4 T cells to PD-1 blockade
F Porichis, DS Kwon, J Zupkosky, DP Tighe, A McMullen, MA Brockman, ...
Blood, The Journal of the American Society of Hematology 118 (4), 965-974, 2011
HIV Increases HCV Replication in a TGF-β1–Dependent Manner
W Lin, EM Weinberg, AW Tai, LF Peng, MA Brockman, KA Kim, SS Kim, ...
Gastroenterology 134 (3), 803-811, 2008
HLA-Associated Alterations in Replication Capacity of Chimeric NL4-3 Viruses Carrying gag-protease from Elite Controllers of Human Immunodeficiency Virus Type 1
T Miura, MA Brockman, ZL Brumme, CJ Brumme, F Pereyra, A Trocha, ...
Journal of virology 83 (1), 140-149, 2009
Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changes
T Miura, MA Brockman, CJ Brumme, ZL Brumme, JM Carlson, F Pereyra, ...
Journal of virology 82 (17), 8422-8430, 2008
Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infection
MA Brockman, ZL Brumme, CJ Brumme, T Miura, J Sela, PC Rosato, ...
Journal of virology 84 (22), 11937-11949, 2010
Humoral response to herpes simplex virus is complement-dependent
XJ Da Costa, MA Brockman, E Alicot, M Ma, MB Fischer, X Zhou, ...
Proceedings of the National Academy of Sciences 96 (22), 12708-12712, 1999
Impaired replication capacity of acute/early viruses in persons who become HIV controllers
T Miura, ZL Brumme, MA Brockman, P Rosato, J Sela, CJ Brumme, ...
Journal of virology 84 (15), 7581-7591, 2010
Selective Depletion of High-Avidity Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+ T Cells after Early HIV-1 Infection
M Lichterfeld, XG Yu, SK Mui, KL Williams, A Trocha, MA Brockman, ...
Journal of virology 81 (8), 4199-4214, 2007
Up-regulation of PD-L1 on monocytes and dendritic cells by HIV-1 derived TLR ligands
A Meier, A Bagchi, HK Sidhu, G Alter, TJ Suscovich, DG Kavanagh, ...
AIDS (London, England) 22 (5), 655, 2008
Construction, phenotypic analysis, and immunogenicity of a UL5/UL29 double deletion mutant of herpes simplex virus 2
X Da Costa, MF Kramer, J Zhu, MA Brockman, DM Knipe
Journal of Virology 74 (17), 7963-7971, 2000
HIV-1 vpu mediates HLA-C downregulation
R Apps, GQ Del Prete, P Chatterjee, A Lara, ZL Brumme, MA Brockman, ...
Cell host & microbe 19 (5), 686-695, 2016
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