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Wynand Smythe
Wynand Smythe
Associate Director - Pharmacometrics (Certara, Cape Town)
Verified email at certara.com - Homepage
Title
Cited by
Cited by
Year
PfPI3K, a phosphatidylinositol-3 kinase from Plasmodium falciparum, is exported to the host erythrocyte and is involved in hemoglobin trafficking
A Vaid, R Ranjan, WA Smythe, HC Hoppe, P Sharma
Blood, The Journal of the American Society of Hematology 115 (12), 2500-2507, 2010
1642010
Comparison of dual therapies for lowering blood pressure in black Africans
DB Ojji, B Mayosi, V Francis, M Badri, V Cornelius, W Smythe, N Kramer, ...
New England Journal of Medicine 380 (25), 2429-2439, 2019
1182019
A semimechanistic pharmacokinetic-enzyme turnover model for rifampin autoinduction in adult tuberculosis patients
W Smythe, A Khandelwal, C Merle, R Rustomjee, M Gninafon, M Bocar Lo, ...
Antimicrobial agents and chemotherapy 56 (4), 2091-2098, 2012
1052012
Actin is required for endocytic trafficking in the malaria parasite Plasmodium falciparum
WA Smythe, KA Joiner, HC Hoppe
Cellular microbiology 10 (2), 452-464, 2008
772008
Bioavailability of two licensed paediatric rifampicin suspensions: implications for quality control programmes
H McIlleron, H Hundt, W Smythe, A Bekker, J Winckler, L Van der Laan, ...
The International Journal of Tuberculosis and Lung Disease 20 (7), 915-919, 2016
262016
Gatifloxacin pharmacokinetics/pharmacodynamics–based optimal dosing for pulmonary and meningeal multidrug-resistant tuberculosis
D Deshpande, JG Pasipanodya, S Srivastava, P Bendet, T Koeuth, ...
Clinical Infectious Diseases 67 (suppl_3), S274-S283, 2018
242018
Evaluation of initial and steady-state gatifloxacin pharmacokinetics and dose in pulmonary tuberculosis patients by using Monte Carlo simulations
W Smythe, CS Merle, R Rustomjee, M Gninafon, MB Lo, O Bah-Sow, ...
Antimicrobial agents and chemotherapy 57 (9), 4164-4171, 2013
232013
Bocar Lo M, Sow OB, Olliaro PL, Lienhardt C, Horton J, Smith P, McIlleron H, Simonsson USH. 2012. A semimechanistic pharmacokinetic-enzyme turnover model for rifampin …
W Smythe, A Khandelwal, C Merle, R Rustomjee, M Gninafon
Antimicrob Agents Chemother 56 (4), 2091-2098, 0
21
Quality assurance of rifampicin-containing fixed-drug combinations in South Africa: dosing implications
MT Chirehwa, L Wiesner, B Wright, W Smythe, N Kramer, H McIlleron
The International Journal of Tuberculosis and Lung Disease 22 (5), 537-543, 2018
152018
Pharmacokinetic profile and safety of adjusted doses of darunavir/ritonavir with rifampicin in people living with HIV
I Ebrahim, G Maartens, L Wiesner, C Orrell, W Smythe, H McIlleron
Journal of Antimicrobial Chemotherapy 75 (4), 1019-1025, 2020
142020
Artificial intelligence–derived 3-way concentration-dependent antagonism of gatifloxacin, pyrazinamide, and rifampicin during treatment of pulmonary tuberculosis
JG Pasipanodya, W Smythe, CS Merle, PL Olliaro, D Deshpande, ...
Clinical Infectious Diseases 67 (suppl_3), S284-S292, 2018
132018
Rationale and design of the comparison of 3 combination therapies in lowering blood pressure in black Africans (CREOLE study): 2× 3 factorial randomized single-blind …
DB Ojji, N Poulter, A Damasceno, K Sliwa, W Smythe, N Kramer, M Badri, ...
American Heart Journal 202, 5-12, 2018
122018
A population pharmacokinetic model for rifampicin auto-induction
P Denti, W Smythe, US Simonsson, R Rustomjee, P Onyebujoh, P Smith, ...
3rd International Workshop on Clinical Pharmacology of TB Drugs, 2010
122010
Characterizing population pharmacokinetic/pharmacodynamic relationships in pulmonary tuberculosis infected adults using nonlinear mixed effects modelling
WA Smythe
62016
Effect of 3, 2-drug combinations of antihypertensive therapies on blood pressure variability in black African patients: Secondary analyses of the CREOLE Trial
DB Ojji, V Cornelius, G Partington, V Francis, S Pandie, W Smythe, ...
Hypertension 79 (11), 2593-2600, 2022
32022
A differential response to antihypertensive therapy in African men and women: insights from the CREOLE trial
DB Ojji, GL Shedul, M Sani, OS Ogah, A Dzudie, F Barasa, C Mondo, ...
American Journal of Hypertension 35 (6), 551-560, 2022
32022
Investigational Medicinal Product (IMP) Management
W Smythe, N Kramer
A Comprehensive and Practical Guide to Clinical Trials, 103-117, 2017
12017
Bioavailability of two licensed paediatric rifampicin suspensions: implications for quality control programmes
AC Hesseling, HJ Zar, H Hundt, H McIlleron, A van Rie, L Wiesner, ...
International Union Against Tuberculosis and Lung Disease, 2016
2016
Characterising the role of actin and PI (3) kinases in endocytosis in the malaria parasite Plasmodium falciparum
WA Smythe
2007
Population Approach Group Europe Population Approach Group Europe
W Smythe
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