Verified email at - Homepage
Cited by
Cited by
Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.
F Oberhammer, JW Wilson, C Dive, ID Morris, JA Hickman, AE Wakeling, ...
The EMBO journal 12 (9), 3679-3684, 1993
Functional and physical interaction between Bcl‐XL and a BH3‐like domain in Beclin‐1
MC Maiuri, G Le Toumelin, A Criollo, JC Rain, F Gautier, P Juin, ...
The EMBO journal 26 (10), 2527-2539, 2007
Apoptosis induced by anticancer drugs
JA Hickman
Cancer and Metastasis Reviews 11 (2), 121-139, 1992
The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice
AJ Merritt, CS Potten, CJ Kemp, JA Hickman, A Balmain, DP Lane, ...
Cancer research 54 (3), 614-617, 1994
Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis
GJ Griffiths, L Dubrez, CP Morgan, NA Jones, J Whitehouse, BM Corfe, ...
The Journal of cell biology 144 (5), 903-914, 1999
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models
A Kotschy, Z Szlavik, J Murray, J Davidson, AL Maragno, ...
Nature 538 (7626), 477-482, 2016
Drug-target interactions: only the first step in the commitment to a programmed cell death?
C Dive, JA Hickman
British journal of cancer 64 (1), 192-196, 1991
Antitumor activity and pharmacokinetics in mice of 8-carbamoyl-3-methyl-imidazo [5, 1-d]-1, 2, 3, 5-tetrazin-4 (3H)-one (CCRG 81045; M & B 39831), a novel drug with potential …
MFG Stevens, JA Hickman, SP Langdon, D Chubb, L Vickers, R Stone, ...
Cancer research 47 (22), 5846-5852, 1987
BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-XL
MC Maiuri, A Criollo, E Tasdemir, JM Vicencio, N Tajeddine, JA Hickman, ...
Autophagy 3 (4), 374-376, 2007
Differential expression of bcl-2 in intestinal epithelia. Correlation with attenuation of apoptosis in colonic crypts and the incidence of colonic neoplasia
AJ Merritt, CS Potten, AJ Watson, DY Loh, K Nakayama, JA Hickman
Journal of cell science 108 (6), 2261-2271, 1995
Hypersensitivity of human testicular tumors to etoposide-induced apoptosis is associated with functional p53 and a high Bax: Bcl-2 ratio
CM Chresta, JRW Masters, JA Hickman
Cancer research 56 (8), 1834-1841, 1996
Requirement of basement membrane for the suppression of programmed cell death in mammary epithelium
S Pullan, J Wilson, A Metcalfe, GM Edwards, N Goberdhan, J Tilly, ...
Journal of cell science 109 (3), 631-642, 1996
bcl-2 modulation of apoptosis induced by anticancer drugs: resistance to thymidylate stress is independent of classical resistance pathways
TC Fisher, AE Milner, CD Gregory, AL Jackman, GW Aherne, JA Hartley, ...
Cancer Research 53 (14), 3321-3326, 1993
Limits to personalized cancer medicine
IF Tannock, JA Hickman
N Engl J Med 375 (13), 1289-1294, 2016
Apoptosis in small intestinal epithelia from p53-null mice: evidence for a delayed, p53-indepdendent G2/M-associated cell death after γ-irradiation
AJ Merritt, TD Allen, CS Potten, JA Hickman
Oncogene 14 (23), 2759-2766, 1997
Apoptosis and cancer chemotherapy
G Makin, JA Hickman
Cell and tissue research 301 (1), 143-152, 2000
Three‐dimensional models of cancer for pharmacology and cancer cell biology: capturing tumor complexity in vitro/ex vivo
JA Hickman, R Graeser, R de Hoogt, S Vidic, C Brito, M Gutekunst, ...
Biotechnology journal 9 (9), 1115-1128, 2014
Antitumour imidazotetrazines. 1. Synthesis and chemistry of 8-carbamoyl-3-(2-chloroethyl) imidazo [5, 1-d]-1, 2, 3, 5-tetrazin-4 (3H)-one, a novel broad-spectrum antitumor agent
MFG Stevens, JA Hickman, R Stone, NW Gibson, GU Baig, E Lunt, ...
Journal of medicinal chemistry 27 (2), 196-201, 1984
Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells
B Marty, V Maire, E Gravier, G Rigaill, A Vincent-Salomon, M Kappler, ...
Breast Cancer Research 10 (6), 1-15, 2008
Apoptosis and chemotherapy resistance
JA Hickman
European Journal of Cancer 32 (6), 921-926, 1996
The system can't perform the operation now. Try again later.
Articles 1–20