X. WillIam Yang
X. WillIam Yang
Professor, Dept. Psychiatry & Semel Institute, David Geffen School of Medicine, UCLA
Verified email at mednet.ucla.edu - Homepage
Cited by
Cited by
Homologous recombination based modification in Esherichia coli and germline transmission in transgenic mice of a bacterial artificial chromsome
XW Yang, P Model, N Heintz
Nature biotechnology 15 (9), 859-865, 1997
Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice
M Gray, DI Shirasaki, C Cepeda, VM André, B Wilburn, XH Lu, J Tao, ...
Journal of Neuroscience 28 (24), 6182-6195, 2008
FACS-array profiling of striatal projection neuron subtypes in juvenile and adult mouse brains
MK Lobo, SL Karsten, M Gray, DH Geschwind, XW Yang
Nature neuroscience 9 (3), 443-452, 2006
Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice
X Gu, ER Greiner, R Mishra, R Kodali, A Osmand, S Finkbeiner, ...
Neuron 64 (6), 828-840, 2009
Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets
M Jiang, J Wang, J Fu, L Du, H Jeong, T West, L Xiang, Q Peng, Z Hou, ...
Nature medicine 18 (1), 153-158, 2012
Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models
L Menalled, BF El-Khodor, M Patry, M Suárez-Fariñas, SJ Orenstein, ...
Neurobiology of disease 35 (3), 319-336, 2009
Highly efficient modification of bacterial artificial chromosomes (BACs) using novel shuttle vectors containing the R6Kγ origin of replication
S Gong, XW Yang, C Li, N Heintz
Genome research 12 (12), 1992-1998, 2002
Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism
O Peñagarikano, MT Lázaro, XH Lu, A Gordon, H Dong, HA Lam, E Peles, ...
Science translational medicine 7 (271), 271ra8-271ra8, 2015
The mouse cortico-striatal projectome
H Hintiryan, NN Foster, I Bowman, M Bay, MY Song, L Gou, S Yamashita, ...
Nature neuroscience 19 (8), 1100-1114, 2016
Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice
X Gu, C Li, W Wei, V Lo, S Gong, SH Li, T Iwasato, S Itohara, XJ Li, I Mody, ...
Neuron 46 (3), 433-444, 2005
Network organization of the huntingtin proteomic interactome in mammalian brain
DI Shirasaki, ER Greiner, I Al-Ramahi, M Gray, P Boontheung, ...
Neuron 75 (1), 41-57, 2012
Integrated genomics and proteomics define huntingtin CAG length–dependent networks in mice
P Langfelder, JP Cantle, D Chatzopoulou, N Wang, F Gao, I Al-Ramahi, ...
Nature neuroscience 19 (4), 623, 2016
Conditions and constraints for astrocyte calcium signaling in the hippocampal mossy fiber pathway
MD Haustein, S Kracun, XH Lu, T Shih, O Jackson-Weaver, X Tong, J Xu, ...
Neuron 82 (2), 413-429, 2014
Identifying polyglutamine protein species in situ that best predict neurodegeneration
J Miller, M Arrasate, E Brooks, CP Libeu, J Legleiter, D Hatters, J Curtis, ...
Nature chemical biology 7 (12), 925-934, 2011
An intact Box C sequence in the U3 snRNA is required for binding of fibrillarin, the protein common to the major family of nucleolar snRNPs.
SJ Baserga, XD Yang, JA Steitz
The EMBO Journal 10 (9), 2645-2651, 1991
Bacterial artificial chromosome transgenic mice expressing a truncated mutant Parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and …
XH Lu, SM Fleming, B Meurers, LC Ackerson, F Mortazavi, V Lo, ...
Journal of Neuroscience 29 (7), 1962-1976, 2009
DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturation
LK Hutnick, P Golshani, M Namihira, Z Xue, A Matynia, XW Yang, AJ Silva, ...
Human molecular genetics 18 (15), 2875-2888, 2009
Deletion of astroglial Dicer causes non-cell-autonomous neuronal dysfunction and degeneration
J Tao, H Wu, Q Lin, W Wei, XH Lu, JP Cantle, Y Ao, RW Olsen, XW Yang, ...
Journal of Neuroscience 31 (22), 8306-8319, 2011
Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease
N Wang, M Gray, XH Lu, JP Cantle, SM Holley, E Greiner, X Gu, ...
Nature medicine 20 (5), 536-541, 2014
Elevated TREM2 gene dosage reprograms microglia responsivity and ameliorates pathological phenotypes in Alzheimer’s disease models
CYD Lee, A Daggett, X Gu, LL Jiang, P Langfelder, X Li, N Wang, Y Zhao, ...
Neuron 97 (5), 1032-1048. e5, 2018
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