High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing CD Sago, MP Lokugamage, K Paunovska, DA Vanover, CM Monaco, ... Proceedings of the National Academy of Sciences 115 (42), E9944-E9952, 2018 | 239 | 2018 |
A direct comparison of in vitro and in vivo nucleic acid delivery mediated by hundreds of nanoparticles reveals a weak correlation K Paunovska, CD Sago, CM Monaco, WH Hudson, MG Castro, ... Nano letters 18 (3), 2148-2157, 2018 | 166 | 2018 |
Nanoparticles containing oxidized cholesterol deliver mRNA to the liver microenvironment at clinically relevant doses K Paunovska, AJ Da Silva Sanchez, CD Sago, Z Gan, MP Lokugamage, ... Advanced materials 31 (14), 1807748, 2019 | 143 | 2019 |
Constrained nanoparticles deliver siRNA and sgRNA to T cells in vivo without targeting ligands MP Lokugamage, CD Sago, Z Gan, BR Krupczak, JE Dahlman Advanced Materials 31 (41), 1902251, 2019 | 111 | 2019 |
Analyzing 2000 in Vivo Drug Delivery Data Points Reveals Cholesterol Structure Impacts Nanoparticle Delivery K Paunovska, CJ Gil, MP Lokugamage, CD Sago, M Sato, GN Lando, ... ACS nano 12 (8), 8341-8349, 2018 | 110 | 2018 |
Nanoparticles that deliver RNA to bone marrow identified by in vivo directed evolution CD Sago, MP Lokugamage, FZ Islam, BR Krupczak, M Sato, JE Dahlman Journal of the American Chemical Society 140 (49), 17095-17105, 2018 | 95 | 2018 |
Mild innate immune activation overrides efficient nanoparticle‐mediated RNA delivery MP Lokugamage, Z Gan, C Zurla, J Levin, FZ Islam, S Kalathoor, M Sato, ... Advanced materials 32 (1), 1904905, 2020 | 88 | 2020 |
Testing thousands of nanoparticles in vivo using DNA barcodes MP Lokugamage, CD Sago, JE Dahlman Current Opinion in Biomedical Engineering 7, 1-8, 2018 | 67 | 2018 |
Using large datasets to understand nanotechnology K Paunovska, D Loughrey, CD Sago, R Langer, JE Dahlman Advanced Materials 31 (43), 1902798, 2019 | 57 | 2019 |
Modifying a commonly expressed endocytic receptor retargets nanoparticles in vivo CD Sago, MP Lokugamage, GN Lando, N Djeddar, NN Shah, C Syed, ... Nano letters 18 (12), 7590-7600, 2018 | 42 | 2018 |
Augmented lipid-nanoparticle-mediated in vivo genome editing in the lungs and spleen by disrupting Cas9 activity in the liver CD Sago, MP Lokugamage, D Loughrey, KE Lindsay, R Hincapie, ... Nature biomedical engineering 6 (2), 157-167, 2022 | 37 | 2022 |
Cell subtypes within the liver microenvironment differentially interact with lipid nanoparticles CD Sago, BR Krupczak, MP Lokugamage, Z Gan, JE Dahlman Cellular and Molecular Bioengineering 12, 389-397, 2019 | 36 | 2019 |
High-throughput screens identify a lipid nanoparticle that preferentially delivers mRNA to human tumors in vivo SG Huayamares, MP Lokugamage, R Rab, AJDS Sanchez, H Kim, ... Journal of Controlled Release 357, 394-403, 2023 | 21 | 2023 |
Barcoding chemical modifications into nucleic acids improves drug stability in vivo CD Sago, S Kalathoor, JP Fitzgerald, GN Lando, N Djeddar, AV Bryksin, ... Journal of materials chemistry B 6 (44), 7197-7203, 2018 | 19 | 2018 |
Screening of chemically distinct lipid nanoparticles in vivo using DNA barcoding technology towards effectively delivering messenger RNA to hematopoietic stem and progenitor cells C Sago, E Campbell, B Lutz, N Patwardhan, G Hamilton, C Wong, D Lee, ... Blood 138, 2931, 2021 | 4 | 2021 |
Nanomaterials GL Hamilton, NN Patwardhan, CD Sago, MFG Shehata, MB Chhabra US Patent App. 17/142,595, 2021 | 1 | 2021 |
Multiplexed Analysis of Materials for Tissue Delivery J Dahlman, S Cory, M Lokugamage US Patent App. 16/753,241, 2020 | 1 | 2020 |
Nanomaterials comprising an ionizable lipid GL Hamilton, MF Shehata, CD Sago, NN Patwardhan, MB Chhabra US Patent App. 18/220,867, 2024 | | 2024 |
Nanomaterials comprising carbonates GL Hamilton, NN Patwardhan, CD Sago, MF Shehata, MB Chhabra US Patent App. 18/211,840, 2023 | | 2023 |
Ionizable lipids for nanomaterials MF Shehata, GL Hamilton, NN Patwardhan, CD Sago, MB Chhabra US Patent App. 18/220,874, 2023 | | 2023 |