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François Hallé
François Hallé
Verified email at univ-lyon1.fr
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Year
TSPO Ligands Boost Mitochondrial Function and Pregnenolone Synthesis
I Lejri, A Grimm, F Hallé, M Abarghaz, C Klein, M Maitre, M Schmitt, ...
Journal of Alzheimer's Disease, 1-14, 2019
602019
The translocator protein ligand XBD173 improves clinical symptoms and neuropathological markers in the SJL/J mouse model of multiple sclerosis
G Leva, C Klein, J Benyounes, F Hallé, F Bihel, N Collongues, J De Seze, ...
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1863 (12 …, 2017
412017
Human erythrocytes release ATP by a novel pathway involving VDAC oligomerization independent of pannexin-1
I Marginedas-Freixa, CL Alvarez, M Moras, MF Leal Denis, C Hattab, ...
Scientific reports 8 (1), 11384, 2018
382018
Mitochondria modulatory effects of new TSPO ligands in a cellular model of tauopathies
A Grimm, I Lejri, F Hallé, M Schmitt, J Götz, F Bihel, A Eckert
Journal of neuroendocrinology 32 (1), e12796, 2020
342020
Emissive Synthetic Cofactors: Enzymatic Interconversions of tzA Analogues of ATP, NAD+, NADH, NADP+, and NADPH
F Hallé, A Fin, AR Rovira, Y Tor
Angewandte Chemie International Edition 57 (4), 1087-1090, 2018
312018
TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human blood
I Marginedas-Freixa, C Hattab, G Bouyer, F Halle, A Chene, SD Lefevre, ...
Scientific reports 6 (1), 33516, 2016
202016
Discovery of imidazoquinazolinone derivatives as TSPO ligands modulating neurosteroidogenesis and cellular bioenergetics in neuroblastoma cells expressing amyloid precursor protein
F Hallé, I Lejri, M Abarghaz, A Grimm, C Klein, M Maitre, M Schmitt, ...
ChemistrySelect 2 (22), 6452-6457, 2017
112017
χ-Space Screening of Dermorphin-Based Tetrapeptides through Use of Constrained Arylazepinone and Quinolinone Scaffolds
O Van der Poorten, R Van Den Hauwe, E Eiselt, C Betti, K Guillemyn, ...
ACS Medicinal Chemistry Letters 8 (11), 1177-1182, 2017
82017
Pharmacomodulation of a ligand targeting the HBV capsid hydrophobic pocket
M Briday, F Hallé, L Lecoq, S Radix, J Martin, R Montserret, M Dujardin, ...
Chemical Science 13 (30), 8840-8847, 2022
32022
Crystal structure and identification of a pyrimido[6,1-b][1,3]oxazin-6-one derivative from the reaction of acrolein with 5-(phenoxymethyl)-2-amino-2-oxazoline
J Guillon, S Rubio, S Savrimoutou, F Hallé, S Moreau, P Sonnet, ...
Comptes Rendus. Chimie 21 (11), 987-992, 2018
32018
Synthesis of 3-amino-3,4-dihydro-1H-quinolin-2-ones through regioselective palladium-catalyzed intramolecular cyclization
F Hallé, O Van der Poorten, C Doebelin, M Niederst, S Schneider, ...
Tetrahedron Letters 57 (14), 1547-1550, 2016
32016
A Journey through Hemetsberger–Knittel, Leimgruber–Batcho and Bartoli Reactions: Access to Several Hydroxy 5‐ and 6‐Azaindoles
S Radix, F Hallé, Z Mahiout, A Teissonnière, G Bouchez, L Auberger, ...
Helvetica Chimica Acta 105 (3), e202100211, 2022
12022
Conception, développement et synthèse de ligands du TSPO dans le but de traiter les maladies neurodégénératives
F Hallé
Université de Strasbourg, 2015
12015
Design, synthesis, and structure–activity relationship studies of 6 H-benzo [b] indeno [1, 2-d] thiophen-6-one derivatives as DYRK1A/CLK1/CLK4/haspin inhibitors
A Faouzi, A Arnaud, F Hallé, J Roussel, M Aymard, V Denavit, CV Do, ...
RSC Medicinal Chemistry, 2024
2024
Synthesis and Evaluation of New 6-formyl-oxazolo [3, 2-a] pyrimidine derivatives as Potential Src Kinase Inhibitors
J Guillon, F Hallé, S Savrimoutou, S Moreau, DH Caignard, P Sonnet
4th International Electronic Conference on Medicinal Chemistry, 5566, 2018
2018
Development of imidazo [1, 2-c] quinazolin-5-ones as neuroprotective agents through 18kDa translocator protein (TSPO) activation
F Halle, I Lejri, C Klein, M Schmitt, A Eckert, G Mensah, JJ Bourguignon, ...
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 251, 2016
2016
L'avenir des ligands du TSPO 18KDA dans le traitement des affections neurologiques
F Hallé
2014
Originally Designed Dyrk1a Inhibitors as Potent Dyrk1a/Clk1/Clk4/Haspin Multiple Inhibitors: Synthesis and Biological Activities of Sulfur-Containing Tetracycles
A Faouzi, A Arnaud, F HALLE, J ROUSSEL, M AYMARD, V DENAVIT, ...
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