The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease JN van der Veen, JP Kennelly, S Wan, JE Vance, DE Vance, RL Jacobs Biochimica et Biophysica Acta (BBA)-Biomembranes 1859 (9), 1558-1572, 2017 | 1013 | 2017 |
Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity DPY Koonen, RL Jacobs, M Febbraio, ME Young, CLM Soltys, H Ong, ... diabetes 56 (12), 2863-2871, 2007 | 559 | 2007 |
A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans AK Walker, RL Jacobs, JL Watts, V Rottiers, K Jiang, DM Finnegan, ... Cell 147 (4), 840-852, 2011 | 453 | 2011 |
Is it time to reevaluate methyl balance in humans? LM Stead, JT Brosnan, ME Brosnan, DE Vance, RL Jacobs The American journal of clinical nutrition 83 (1), 5-10, 2006 | 315 | 2006 |
Effects of streptozotocin-induced diabetes and of insulin treatment on homocysteine metabolism in the rat. RL Jacobs, JD House, ME Brosnan, JT Brosnan Diabetes 47 (12), 1967-1970, 1998 | 266 | 1998 |
Methylation demand and homocysteine metabolism: effects of dietary provision of creatine and guanidinoacetate LM Stead, KP Au, RL Jacobs, ME Brosnan, JT Brosnan American Journal of Physiology-Endocrinology and Metabolism 281 (5), E1095-E1100, 2001 | 258 | 2001 |
Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity RL Jacobs, Y Zhao, DPY Koonen, T Sletten, B Su, S Lingrell, G Cao, ... Journal of Biological Chemistry 285 (29), 22403-22413, 2010 | 234 | 2010 |
Targeted deletion of hepatic CTP: phosphocholine cytidylyltransferase α in mice decreases plasma high density and very low density lipoproteins RL Jacobs, C Devlin, I Tabas, DE Vance Journal of Biological Chemistry 279 (45), 47402-47410, 2004 | 214 | 2004 |
Methyl balance and transmethylation fluxes in humans SH Mudd, JT Brosnan, ME Brosnan, RL Jacobs, SP Stabler, RH Allen, ... The American journal of clinical nutrition 85 (1), 19-25, 2007 | 213 | 2007 |
Methylation demand: a key determinant of homocysteine metabolism. J Brosnan, R Jacobs, L Stead, M Brosnan Acta biochimica polonica 51 (2), 405-413, 2004 | 211 | 2004 |
Novel insights on interactions between folate and lipid metabolism RP da Silva, KB Kelly, A Al Rajabi, RL Jacobs Biofactors 40 (3), 277-283, 2014 | 189 | 2014 |
Hormonal regulation of cystathionine β-synthase expression in liver S Ratnam, KN Maclean, RL Jacobs, ME Brosnan, JP Kraus, JT Brosnan Journal of Biological Chemistry 277 (45), 42912-42918, 2002 | 179 | 2002 |
A systematic review on the effect of sweeteners on glycemic response and clinically relevant outcomes N Wiebe, R Padwal, C Field, S Marks, R Jacobs, M Tonelli BMC medicine 9, 1-18, 2011 | 178 | 2011 |
Tamoxifen induces triacylglycerol accumulation in the mouse liver by activation of fatty acid synthesis LK Cole, RL Jacobs, DE Vance Hepatology 52 (4), 1258-1265, 2010 | 132 | 2010 |
Regulation of homocysteine metabolism JD House, RL Jacobs, LM Stead, ME Brosnan, JT Brosnan Advances in enzyme regulation 39 (1), 69-91, 1999 | 131 | 1999 |
Hepatic phosphatidylethanolamine N-methyltransferase, unexpected roles in animal biochemistry and physiology DE Vance, Z Li, RL Jacobs Journal of Biological Chemistry 282 (46), 33237-33241, 2007 | 116 | 2007 |
Physiological regulation of phospholipid methylation alters plasma homocysteine in mice RL Jacobs, LM Stead, C Devlin, I Tabas, ME Brosnan, JT Brosnan, ... Journal of Biological Chemistry 280 (31), 28299-28305, 2005 | 116 | 2005 |
Hepatic CTP: phosphocholine cytidylyltransferase-α is a critical predictor of plasma high density lipoprotein and very low density lipoprotein RL Jacobs, S Lingrell, Y Zhao, GA Francis, DE Vance Journal of biological chemistry 283 (4), 2147-2155, 2008 | 109 | 2008 |
Increased hepatic CD36 expression with age is associated with enhanced susceptibility to nonalcoholic fatty liver disease F Sheedfar, MMY Sung, M Aparicio-Vergara, NJ Kloosterhuis, ... Aging (Albany NY) 6 (4), 281, 2014 | 104 | 2014 |
Hepatic ratio of phosphatidylcholine to phosphatidylethanolamine predicts survival after partial hepatectomy in mice J Ling, T Chaba, LF Zhu, RL Jacobs, DE Vance Hepatology 55 (4), 1094-1102, 2012 | 103 | 2012 |