Darren N Saunders
Darren N Saunders
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CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
H Xu, M Di Antonio, S McKinney, V Mathew, B Ho, NJ O’Neil, ND Santos, ...
Nature communications 8 (1), 14432, 2017
TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes
T Gudjonsson, M Altmeyer, V Savic, L Toledo, C Dinant, M Grøfte, ...
Cell 150 (4), 697-709, 2012
Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration
S Balaban, RF Shearer, LS Lee, M van Geldermalsen, M Schreuder, ...
Cancer & metabolism 5, 1-14, 2017
Towards clinical translation of ligand-functionalized liposomes in targeted cancer therapy: Challenges and opportunities
L Belfiore, DN Saunders, M Ranson, KJ Thurecht, G Storm, KL Vine
Journal of controlled release 277, 1-13, 2018
Walking the tightrope: proteostasis and neurodegenerative disease
JJ Yerbury, L Ooi, A Dillin, DN Saunders, DM Hatters, PM Beart, ...
Journal of neurochemistry 137 (4), 489-505, 2016
Revisiting the biological roles of PAI2 (SERPINB2) in cancer
DR Croucher, DN Saunders, S Lobov, M Ranson
Nature Reviews Cancer 8 (7), 535-545, 2008
Systematic approaches to identify E3 ligase substrates
M Iconomou, DN Saunders
Biochemical Journal 473 (22), 4083-4101, 2016
Distinct partitioning of ALS associated TDP-43, FUS and SOD1 mutants into cellular inclusions
NE Farrawell, IA Lambert-Smith, ST Warraich, IP Blair, DN Saunders, ...
Scientific reports 5 (1), 13416, 2015
Adipocyte–tumor cell metabolic crosstalk in breast cancer
AJ Hoy, S Balaban, DN Saunders
Trends in molecular medicine 23 (5), 381-392, 2017
Functional roles of the E3 ubiquitin ligase UBR5 in cancer
RF Shearer, M Iconomou, CKW Watts, DN Saunders
Molecular Cancer Research 13 (12), 1523-1532, 2015
Distinct requirement for an intact dimer interface in wild‐type, V600E and kinase‐dead B‐Raf signalling
M Röring, R Herr, GJ Fiala, K Heilmann, S Braun, AE Eisenhardt, ...
The EMBO journal 31 (11), 2629-2647, 2012
Loss of Cited2 affects trophoblast formation and vascularization of the mouse placenta
SL Withington, AN Scott, DN Saunders, KL Floro, JI Preis, J Michalicek, ...
Developmental biology 294 (1), 67-82, 2006
Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS
P Ciryam, IA Lambert-Smith, DM Bean, R Freer, F Cid, GG Tartaglia, ...
Proceedings of the National Academy of Sciences 114 (20), E3935-E3943, 2017
Germline mutations in CDH1 are infrequent in women with early-onset or familial lobular breast cancers
KA Schrader, S Masciari, N Boyd, C Salamanca, J Senz, DN Saunders, ...
Journal of medical genetics 48 (1), 64-68, 2011
Membranous expression of secreted frizzled-related protein 4 predicts for good prognosis in localized prostate cancer and inhibits PC3 cellular proliferation in vitro
LG Horvath, SM Henshall, JG Kench, DN Saunders, CS Lee, D Golovsky, ...
Clinical cancer research 10 (2), 615-625, 2004
Involvement of Lyn and the atypical kinase SgK269/PEAK1 in a basal breast cancer signaling pathway
DR Croucher, F Hochgräfe, L Zhang, L Liu, RJ Lyons, D Rickwood, ...
Cancer research 73 (6), 1969-1980, 2013
Plasminogen binding and activation at the breast cancer cell surface: the integral role of urokinase activity
GE Stillfried, DN Saunders, M Ranson
Breast Cancer Research 9, 1-11, 2007
SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer
NLE Harris, C Vennin, JRW Conway, KL Vine, M Pinese, MJ Cowley, ...
Oncogene 36 (30), 4288-4298, 2017
Experimental design for stable genetic manipulation in mammalian cell lines: lentivirus and alternatives
R Shearer, S Darren
Genes to Cells, 2014
Edd, the Murine Hyperplastic Disc Gene, Is Essential for Yolk Sac Vascularization and Chorioallantoic Fusion
DN Saunders, SL Hird, SL Withington, SL Dunwoodie, MJ Henderson, ...
Molecular and cellular biology 24 (16), 7225-7234, 2004
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