Follow
Brendan D. Manning
Brendan D. Manning
Verified email at hsph.harvard.edu - Homepage
Title
Cited by
Cited by
Year
AKT/PKB signaling: navigating downstream
BD Manning, LC Cantley
Cell 129 (7), 1261-1274, 2007
72722007
AKT/PKB signaling: navigating the network
BD Manning, A Toker
Cell 169 (3), 381-405, 2017
31062017
Activation of a metabolic gene regulatory network downstream of mTOR complex 1
K Düvel, JL Yecies, S Menon, P Raman, AI Lipovsky, AL Souza, ...
Molecular cell 39 (2), 171-183, 2010
21872010
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
BD Manning, AR Tee, MN Logsdon, J Blenis, LC Cantley
Molecular cell 10 (1), 151-162, 2002
19242002
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
J Brugarolas, K Lei, RL Hurley, BD Manning, JH Reiling, E Hafen, ...
Genes & development 18 (23), 2893-2904, 2004
16712004
Targeting the PI3K-Akt pathway in human cancer: rationale and promise
J Luo, BD Manning, LC Cantley
Cancer cell 4 (4), 257-262, 2003
16702003
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
AR Tee, BD Manning, PP Roux, LC Cantley, J Blenis
Current biology 13 (15), 1259-1268, 2003
14942003
The TSC1–TSC2 complex: a molecular switchboard controlling cell growth
J Huang, BD Manning
Biochemical Journal 412 (2), 179-190, 2008
14412008
The PI3K–AKT network at the interface of oncogenic signalling and cancer metabolism
G Hoxhaj, BD Manning
Nature Reviews Cancer 20 (2), 74-88, 2020
12772020
The LKB1 tumor suppressor negatively regulates mTOR signaling
RJ Shaw, N Bardeesy, BD Manning, L Lopez, M Kosmatka, RA DePinho, ...
Cancer cell 6 (1), 91-99, 2004
12442004
Tuberous sclerosis complex-1 and-2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
AR Tee, DC Fingar, BD Manning, DJ Kwiatkowski, LC Cantley, J Blenis
Proceedings of the National Academy of Sciences 99 (21), 13571-13576, 2002
10172002
A complex interplay between Akt, TSC2 and the two mTOR complexes
J Huang, BD Manning
Biochemical Society Transactions 37 (1), 217-222, 2009
8972009
Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome
S Menon, CC Dibble, G Talbott, G Hoxhaj, AJ Valvezan, H Takahashi, ...
Cell 156 (4), 771-785, 2014
8382014
Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1
I Ben-Sahra, JJ Howell, JM Asara, BD Manning
Science 339 (6125), 1323-1328, 2013
7842013
Signal integration by mTORC1 coordinates nutrient input with biosynthetic output
CC Dibble, BD Manning
Nature cell biology 15 (6), 555-564, 2013
7812013
mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle
I Ben-Sahra, G Hoxhaj, SJH Ricoult, JM Asara, BD Manning
Science 351 (6274), 728-733, 2016
7282016
TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1
CC Dibble, W Elis, S Menon, W Qin, J Klekota, JM Asara, PM Finan, ...
Molecular cell 47 (4), 535-546, 2012
6622012
Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways
JL Yecies, HH Zhang, S Menon, S Liu, D Yecies, AI Lipovsky, C Gorgun, ...
Cell metabolism 14 (1), 21-32, 2011
6602011
The TSC1-TSC2 complex is required for proper activation of mTOR complex 2
J Huang, CC Dibble, M Matsuzaki, BD Manning
Molecular and cellular biology 28 (12), 4104-4115, 2008
6522008
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo
WE Dowdle, B Nyfeler, J Nagel, RA Elling, S Liu, E Triantafellow, ...
Nature cell biology 16 (11), 1069-1079, 2014
6462014
The system can't perform the operation now. Try again later.
Articles 1–20