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Michael J Eddins
Michael J Eddins
Verified email at merck.com
Title
Cited by
Cited by
Year
Ubiquitin: structures, functions, mechanisms
CM Pickart, MJ Eddins
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1695 (1-3), 55-72, 2004
19562004
Mms2–Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formation
MJ Eddins, CM Carlile, KM Gomez, CM Pickart, C Wolberger
Nature structural & molecular biology 13 (10), 915-920, 2006
3752006
A conserved catalytic residue in the ubiquitin‐conjugating enzyme family
PY Wu, M Hanlon, M Eddins, C Tsui, RS Rogers, JP Jensen, MJ Matunis, ...
The EMBO journal, 2003
2272003
Crystal structure and solution NMR studies of Lys48-linked tetraubiquitin at neutral pH
MJ Eddins, R Varadan, D Fushman, CM Pickart, C Wolberger
Journal of molecular biology 367 (1), 204-211, 2007
2252007
A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein
A Tang, Z Chen, KS Cox, HP Su, C Callahan, A Fridman, L Zhang, ...
Nature communications 10 (1), 4153, 2019
782019
Targeting the ubiquitin E3 ligase MuRF1 to inhibit muscle atrophy
MJ Eddins, JG Marblestone, KG Suresh Kumar, CA Leach, DE Sterner, ...
Cell biochemistry and biophysics 60, 113-118, 2011
682011
Comprehensive ubiquitin E2 profiling of ten ubiquitin E3 ligases
JG Marblestone, S Butt, DM McKelvey, DE Sterner, MR Mattern, ...
Cell biochemistry and biophysics 67, 161-167, 2013
302013
Crystallization and low-resolution structure of an effector-caspase/P35 complex: similarities and differences to an initiator-caspase/P35 complex
MJ Eddins, D Lemongello, PD Friesen, AJ Fisher
Acta Crystallographica Section D: Biological Crystallography 58 (2), 299-302, 2002
262002
Bioluminescence assay platform for selective and sensitive detection of Ub/Ubl proteases
SJ Orcutt, J Wu, MJ Eddins, CA Leach, JE Strickler
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1823 (11), 2079-2086, 2012
252012
Novel approach for characterizing ubiquitin E3 ligase function
JG Marblestone, KG Suresh Kumar, MJ Eddins, CA Leach, DE Sterner, ...
Journal of biomolecular screening 15 (10), 1220-1228, 2010
182010
Discovery of therapeutic deubiquitylase effector molecules: current perspectives
B Nicholson, S Kumar, S Agarwal, MJ Eddins, JG Marblestone, J Wu, ...
Journal of biomolecular screening 19 (7), 989-999, 2014
152014
Discovery of a new class of integrin antibodies for fibrosis
J Zhang, T Wang, A Saigal, J Johnson, J Morrisson, S Tabrizifard, ...
Scientific Reports 11 (1), 2118, 2021
142021
Protein microarrays for the identification of praja1 e3 ubiquitin ligase substrates
CM Loch, MJ Eddins, JE Strickler
Cell biochemistry and biophysics 60, 127-135, 2011
142011
Profiling of hMPV F-specific antibodies isolated from human memory B cells
X Xiao, A Fridman, L Zhang, P Pristatsky, E Durr, M Minnier, A Tang, ...
Nature Communications 13 (1), 2546, 2022
102022
Di-and poly-ubiquitin deubiquitinase substrates and uses thereof
D Chelur, M Eddins, C Leach, SJ Orcutt, RJ Peroutka, J Strickler, Y Yan, ...
US Patent 8,518,660, 2013
72013
Proteasome inhibitors versus E3 ligase inhibitors for cancer therapy
MR Mattern, MJ Eddins, S Agarwal, DE Sterner, MP Kodrasov, ...
Resistance to Proteasome Inhibitors in Cancer: Molecular Mechanisms and …, 2014
32014
Discovery and multimerization of cross-reactive single-domain antibodies against SARS-like viruses to enhance potency and address emerging SARS-CoV-2 variants
SA Hollingsworth, CL Noland, K Vroom, A Saha, M Sam, Q Gao, H Zhou, ...
Scientific Reports 13 (1), 13668, 2023
22023
Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases
VA Kleiner, T O. Fischmann, JA Howe, DC Beshore, MJ Eddins, Y Hou, ...
Communications Biology 6 (1), 649, 2023
22023
Ubiquitin‐conjugating Enzymes
MJ Eddins, CM Pickart
Protein Science Encyclopedia: online, 102-134, 2008
22008
Abstract A21: Inhibition of USP7 for the treatment of multiple myeloma and other malignancies.
B Nicholson, MP Kodrasov, JP LaRocque, MJ Eddins, S Kumar, ...
Clinical Cancer Research 21 (17_Supplement), A21-A21, 2015
12015
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