| Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition JF Ohren, H Chen, A Pavlovsky, C Whitehead, E Zhang, P Kuffa, C Yan, ... Nature structural & molecular biology 11 (12), 1192-1197, 2004 | 745 | 2004 |
| Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes QJ Meng, ES Maywood, DA Bechtold, WQ Lu, J Li, JE Gibbs, SM Dupré, ... Proceedings of the National Academy of Sciences 107 (34), 15240-15245, 2010 | 256 | 2010 |
| Selective inhibition of casein kinase 1ϵ minimally alters circadian clock period KM Walton, K Fisher, D Rubitski, M Marconi, QJ Meng, M Sladek, J Adams, ... Journal of Pharmacology and Experimental Therapeutics 330 (2), 430-439, 2009 | 210 | 2009 |
| The Structure of the Carboxyltransferase Component of Acetyl-CoA Carboxylase Reveals a Zinc-Binding Motif Unique to the Bacterial Enzyme, P Bilder, S Lightle, G Bainbridge, J Ohren, B Finzel, F Sun, S Holley, ... Biochemistry 45 (6), 1712-1722, 2006 | 91 | 2006 |
| Discovery of a Series of Imidazo[4,5-b]pyridines with Dual Activity at Angiotensin II Type 1 Receptor and Peroxisome Proliferator-Activated Receptor-γ A Casimiro-Garcia, GF Filzen, D Flynn, CF Bigge, J Chen, JA Davis, ... Journal of medicinal chemistry 54 (12), 4219-4233, 2011 | 80 | 2011 |
| 2-Alkylamino-and alkoxy-substituted 2-amino-1, 3, 4-oxadiazoles—O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK … JS Warmus, C Flamme, LY Zhang, S Barrett, A Bridges, H Chen, R Gowan, ... Bioorganic & medicinal chemistry letters 18 (23), 6171-6174, 2008 | 73 | 2008 |
| 4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase JA Spicer, GW Rewcastle, MD Kaufman, SL Black, MS Plummer, ... Journal of medicinal chemistry 50 (21), 5090-5102, 2007 | 56 | 2007 |
| Characterization of substrate binding and catalysis in the potential antibacterial target N‐acetylglucosamine‐1‐phosphate uridyltransferase (GlmU) I Mochalkin, S Lightle, Y Zhu, JF Ohren, C Spessard, NY Chirgadze, ... Protein Science 16 (12), 2657-2666, 2007 | 54 | 2007 |
| A new branch in the family: structure of aspartate-β-semialdehyde dehydrogenase from Methanococcus jannaschii CR Faehnle, JF Ohren, RE Viola Journal of molecular biology 353 (5), 1055-1068, 2005 | 47 | 2005 |
| Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK? H Tecle, J Shao, Y Li, M Kothe, S Kazmirski, J Penzotti, YH Ding, J Ohren, ... Bioorganic & Medicinal Chemistry Letters 19 (1), 226-229, 2009 | 42 | 2009 |
| Design, synthesis, and evaluation of imidazo [4, 5-c] pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated … A Casimiro-Garcia, RJ Heemstra, CF Bigge, J Chen, FA Ciske, JA Davis, ... Bioorganic & medicinal chemistry letters 23 (3), 767-772, 2013 | 36 | 2013 |
| Dynamic light-scattering analysis of full-length human RPA14/32 dimer: purification, crystallization and self-association JE Habel, JF Ohren, GEO Borgstahl Acta Crystallographica Section D: Biological Crystallography 57 (2), 254-259, 2001 | 36 | 2001 |
| Structural asymmetry and intersubunit communication in muscle creatine kinase JF Ohren, ML Kundracik, CL Borders, P Edmiston, RE Viola Acta Crystallographica Section D: Biological Crystallography 63 (3), 381-389, 2007 | 34 | 2007 |
| Effects of modifications of the linker in a series of phenylpropanoic acid derivatives: Synthesis, evaluation as PPARα/γ dual agonists, and X-ray crystallographic studies A Casimiro-Garcia, CF Bigge, JA Davis, T Padalino, J Pulaski, JF Ohren, ... Bioorganic & medicinal chemistry 16 (9), 4883-4907, 2008 | 32 | 2008 |
| Modified MEK1 and MEK2, crystal of a peptide: ligand: cofactor complex containing such modified MEK1 or MEK2, and methods of use thereof J Ohren, H Chen, A Delaney, D Dudley, C Hasemann, P Kuffa, ... US Patent App. 10/324,130, 2003 | 31 | 2003 |
| Aminopyrazole carboxamide bruton’s tyrosine kinase inhibitors. irreversible to reversible covalent reactive group tuning ME Schnute, SE Benoit, IP Buchler, N Caspers, ML Grapperhaus, S Han, ... ACS Medicinal Chemistry Letters 10 (1), 80-85, 2018 | 30 | 2018 |
| Synthesis and evaluation of novel α-heteroaryl-phenylpropanoic acid derivatives as PPARα/γ dual agonists A Casimiro-Garcia, CF Bigge, JA Davis, T Padalino, J Pulaski, JF Ohren, ... Bioorganic & medicinal chemistry 17 (20), 7113-7125, 2009 | 27 | 2009 |
| The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases LY Hu, PA Boxer, SR Kesten, HJ Lei, DJ Wustrow, DW Moreland, L Zhang, ... Bioorganic & medicinal chemistry letters 16 (9), 2337-2340, 2006 | 26 | 2006 |
| Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors S Han, RM Czerwinski, NL Caspers, DC Limburg, WD Ding, H Wang, ... Biochemical Journal 460 (2), 211-222, 2014 | 25 | 2014 |
| The structure of a redundant enzyme: a second isoform of aspartate β-semialdehyde dehydrogenase in Vibrio cholerae RE Viola, X Liu, JF Ohren, CR Faehnle Acta Crystallographica Section D: Biological Crystallography 64 (3), 321-330, 2008 | 24 | 2008 |
Judith LeopoldVerified email at mekanistictherapeutics.com
