Dennis Wolan
Dennis Wolan
Senior Principal Scientist, Genentech
Verified email at - Homepage
Cited by
Cited by
METLIN: a technology platform for identifying knowns and unknowns
C Guijas, JR Montenegro-Burke, X Domingo-Almenara, A Palermo, ...
Analytical chemistry 90 (5), 3156-3164, 2018
Proteome-wide covalent ligand discovery in native biological systems
KM Backus, BE Correia, KM Lum, S Forli, BD Horning, GE González-Páez, ...
Nature 534 (7608), 570-574, 2016
Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic
EN Chin, C Yu, VF Vartabedian, Y Jia, M Kumar, AM Gamo, W Vernier, ...
Science 369 (6506), 993-999, 2020
Domain swapping in inducible nitric-oxide synthase: electron transfer occurs between flavin and heme groups located on adjacent subunits in the dimer
U Siddhanta, A Presta, B Fan, D Wolan, DL Rousseau, DJ Stuehr
Journal of biological chemistry 273 (30), 18950-18958, 1998
Acetone‐linked peptides: a convergent approach for peptide macrocyclization and labeling
N Assem, DJ Ferreira, DW Wolan, PE Dawson
Angewandte Chemie 127 (30), 8789-8792, 2015
Small-molecule activators of a proenzyme
DW Wolan, JA Zorn, DC Gray, JA Wells
Science 326 (5954), 853-858, 2009
Turning a protein kinase on or off from a single allosteric site via disulfide trapping
JD Sadowsky, MA Burlingame, DW Wolan, CL McClendon, MP Jacobson, ...
Proceedings of the National Academy of Sciences 108 (15), 6056-6061, 2011
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
Q Zheng, JL Woehl, S Kitamura, D Santos-Martins, CJ Smedley, G Li, ...
Proceedings of the National Academy of Sciences 116 (38), 18808-18814, 2019
Antifungal imidazoles block assembly of inducible NO synthase into an active dimer
N Sennequier, D Wolan, DJ Stuehr
Journal of Biological Chemistry 274 (2), 930-938, 1999
Sulfur (VI) fluoride exchange (SuFEx)-enabled high-throughput medicinal chemistry
S Kitamura, Q Zheng, JL Woehl, A Solania, E Chen, N Dillon, MV Hull, ...
Journal of the American Chemical Society 142 (25), 10899-10904, 2020
Crystal structure of the murine NK cell–activating receptor NKG2D at 1.95 Å
DW Wolan, L Teyton, MG Rudolph, B Villmow, S Bauer, DH Busch, ...
Nature immunology 2 (3), 248-254, 2001
Diversity oriented clicking (DOC): divergent synthesis of SuFExable pharmacophores from 2‐substituted‐alkynyl‐1‐sulfonyl fluoride (SASF) hubs
CJ Smedley, G Li, AS Barrow, TL Gialelis, MC Giel, A Ottonello, Y Cheng, ...
Angewandte Chemie 132 (30), 12560-12569, 2020
Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors
C Li, L Xu, DW Wolan, IA Wilson, AJ Olson
Journal of medicinal chemistry 47 (27), 6681-6690, 2004
Self-assembling small molecules form nanofibrils that bind procaspase-3 to promote activation
JA Zorn, H Wille, DW Wolan, JA Wells
Journal of the American Chemical Society 133 (49), 19630-19633, 2011
Inducible nitric oxide synthase: role of the N‐terminal β‐hairpin hook and pterin‐binding segment in dimerization and tetrahydrobiopterin interaction
DK Ghosh, BR Crane, S Ghosh, D Wolan, R Gachhui, C Crooks, A Presta, ...
The EMBO journal, 1999
Genetic basis for the cooperative bioactivation of plant lignans by Eggerthella lenta and other human gut bacteria
EN Bess, JE Bisanz, F Yarza, A Bustion, BE Rich, X Li, S Kitamura, ...
Nature microbiology 5 (1), 56-66, 2020
Mutational analysis of the tetrahydrobiopterin-binding site in inducible nitric-oxide synthase
S Ghosh, D Wolan, S Adak, BR Crane, NS Kwon, JA Tainer, ED Getzoff, ...
Journal of Biological Chemistry 274 (34), 24100-24112, 1999
Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates
CG Cheong, DW Wolan, SE Greasley, PA Horton, GP Beardsley, ...
Journal of Biological Chemistry 279 (17), 18034-18045, 2004
Quantitative metaproteomics and activity-based probe enrichment reveals significant alterations in protein expression from a mouse model of inflammatory bowel disease
MD Mayers, C Moon, GS Stupp, AI Su, DW Wolan
Journal of proteome research 16 (2), 1014-1026, 2017
Structure-based optimization and synthesis of antiviral drug Arbidol analogues with significantly improved affinity to influenza hemagglutinin
ZVF Wright, NC Wu, RU Kadam, IA Wilson, DW Wolan
Bioorganic & medicinal chemistry letters 27 (16), 3744-3748, 2017
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