David Leggat
David Leggat
Walter Reed Army Institute of Research - Military HIV Research Program
Verified email at
Cited by
Cited by
Defining B cell immunodominance to viruses
D Angeletti, JS Gibbs, M Angel, I Kosik, HD Hickman, GM Frank, SR Das, ...
Nature immunology 18 (4), 456-463, 2017
Vaccination induces HIV broadly neutralizing antibody precursors in humans
DJ Leggat, KW Cohen, JR Willis, WJ Fulp, AC Decamp, O Kalyuzhniy, ...
Science 378 (6623), eadd6502, 2022
Potent Zika and dengue cross-neutralizing antibodies induced by Zika vaccination in a dengue-experienced donor
V Dussupt, RS Sankhala, GD Gromowski, G Donofrio, RA De La Barrera, ...
Nature medicine 26 (2), 228-235, 2020
The immune response to pneumococcal polysaccharides 14 and 23F among elderly individuals consists predominantly of switched memory B cells
DJ Leggat, RS Thompson, NM Khaskhely, AS Iyer, MAJ Westerink
The Journal of infectious diseases 208 (1), 101-108, 2013
Pneumococcal polysaccharide vaccination induces polysaccharide-specific B cells in adult peripheral blood expressing CD19+ CD20+ CD3− CD70− CD27+ IgM+ CD43+ CD5+/−
DJ Leggat, NM Khaskhely, AS Iyer, J Mosakowski, RS Thompson, ...
Vaccine 31 (41), 4632-4640, 2013
Response to pneumococcal polysaccharide vaccination in newly diagnosed HIV-positive individuals
DJ Leggat, AS Iyer, JA Ohtola, S Kommoori, JM Duggan, CA Georgescu, ...
Journal of AIDS & clinical research 6 (2), 2015
A novel method to incorporate bioactive cytokines as adjuvants on the surface of virus particles
Y Yang, D Leggat, A Herbert, PC Roberts, RS Sundick
Journal of Interferon and Cytokine Research 29 (1), 9-22, 2009
Response to pneumococcal polysaccharide vaccination in HIV-positive individuals on long term highly active antiretroviral therapy
AS Iyer, DJ Leggat, JA Ohtola, JM Duggan, CA Georgescu, AA Al Rizaiza, ...
Journal of AIDS & clinical research 6 (2), 2015
B cell engagement with HIV-1 founder virus envelope predicts development of broadly neutralizing antibodies
SM Townsley, GC Donofrio, N Jian, DJ Leggat, V Dussupt, ...
Cell host & microbe 29 (4), 564-578. e9, 2021
A first-in-human germline-targeting HIV nanoparticle vaccine induced broad and publicly targeted helper T cell responses
KW Cohen, SC De Rosa, WJ Fulp, AC deCamp, A Fiore-Gartland, ...
Science translational medicine 15 (697), eadf3309, 2023
Quantitative and functional antibody responses to the 13-valent conjugate and/or 23-valent purified polysaccharide vaccine in aging HIV-infected adults
JA Ohtola, JL Saul-McBeth, AS Iyer, DJ Leggat, SA Khuder, ...
Journal of AIDS & clinical research 7 (3), 2016
Alterations in serotype-specific B cell responses to the 13-valent pneumococcal conjugate vaccine in aging HIV-infected adults
JA Ohtola, NM Khaskhely, JL Saul-Mcbeth, AS Iyer, DJ Leggat, ...
Vaccine 34 (4), 451-457, 2016
Inflammatory markers and immune response to pneumococcal vaccination in HIV-positive and-negative adults
AS Iyer, NM Khaskhely, DJ Leggat, JA Ohtola, JL Saul-McBeth, ...
Plos one 11 (3), e0150261, 2016
Adjuvanted SARS-CoV-2 spike protein vaccination elicits long-lived plasma cells in nonhuman primates
M Prabhakaran, F Matassoli, D Leggat, A Hoover, A Srikanth, W Wu, ...
Science Translational Medicine 16 (728), eadd5960, 2024
Recombinant MVA-prime elicits neutralizing antibody responses by inducing antigen-specific B cells in the germinal center
L Eslamizar, C Petrovas, DJ Leggat, K Furr, ML Lifton, G Levine, S Ma, ...
npj Vaccines 6 (1), 15, 2021
Human immunoglobulin gene allelic variation impacts germline-targeting vaccine priming
AC Decamp, MM Corcoran, WJ Fulp, JR Willis, CA Cottrell, DLV Bader, ...
npj Vaccines 9 (1), 58, 2024
No benefit to delaying pneumococcal polysaccharide vaccination in HIV-positive adults
DJ Leggat, AS Iyer, MAJ Westerink
The Journal of Infectious Diseases 212 (11), 1851-1852, 2015
Isolation and characterization of human polyreactive pneumococcal polysaccharide antibodies
RS Thompson, NM Khaskhely, KR Malhotra, DJ Leggat, J Mosakowski, ...
Open Journal of Immunology 2 (3), 98-110, 2012
Zika-specific neutralizing antibodies targeting inter-dimer envelope epitopes
RS Sankhala, V Dussupt, G Donofrio, GD Gromowski, A Rafael, ...
Cell reports 42 (8), 2023
Safety and Immunogenicity of Accelerated Heterologous Two-dose Ebola Vaccine Regimens in Adults With and Without HIV in Africa
B Mwesigwa, F Sawe, J Oyieko, J Mwakisisile, E Viegas, GA Akintunde, ...
Clinical Infectious Diseases, ciae215, 2024
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