Follow
Nicholas Caron
Nicholas Caron
Postdoctoral fellow at Centre for Molecular Medicine and Therapeutics
Verified email at cmmt.ubc.ca
Title
Cited by
Cited by
Year
Kinase inhibitors modulate huntingtin cell localization and toxicity
RS Atwal, CR Desmond, N Caron, T Maiuri, J Xia, S Sipione, R Truant
Nature chemical biology 7 (7), 453-460, 2011
2072011
Huntington disease
NS Caron, GEB Wright, MR Hayden
GeneReviews®[Internet], 2020
1672020
Mutant huntingtin causes defective actin remodeling during stress: defining a new role for transglutaminase 2 in neurodegenerative disease
L Munsie, N Caron, RS Atwal, I Marsden, EJ Wild, JR Bamburg, SJ Tabrizi, ...
Human molecular genetics 20 (10), 1937-1951, 2011
1622011
Polyglutamine domain flexibility mediates the proximity between flanking sequences in huntingtin
NS Caron, CR Desmond, J Xia, R Truant
Proceedings of the National Academy of Sciences 110 (36), 14610-14615, 2013
1522013
Therapeutic approaches to Huntington disease: from the bench to the clinic
NS Caron, ER Dorsey, MR Hayden
Nature Reviews Drug Discovery 17 (10), 729-750, 2018
1482018
Huntingtin haplotypes provide prioritized target panels for allele-specific silencing in Huntington disease patients of European ancestry
C Kay, JA Collins, NH Skotte, AL Southwell, SC Warby, NS Caron, ...
Molecular Therapy 23 (11), 1759-1771, 2015
1112015
Huntingtin suppression restores cognitive function in a mouse model of Huntington’s disease
AL Southwell, HB Kordasiewicz, D Langbehn, NH Skotte, MP Parsons, ...
Science translational medicine 10 (461), eaar3959, 2018
1082018
Ultrasensitive measurement of huntingtin protein in cerebrospinal fluid demonstrates increase with Huntington disease stage and decrease following brain huntingtin suppression
AL Southwell, SEP Smith, TR Davis, NS Caron, EB Villanueva, Y Xie, ...
Scientific reports 5 (1), 12166, 2015
1082015
Using FLIM-FRET to measure conformational changes of transglutaminase type 2 in live cells
NS Caron, LN Munsie, JW Keillor, R Truant
Public Library of Science 7 (8), e44159, 2012
942012
Intrinsic mutant HTT-mediated defects in oligodendroglia cause myelination deficits and behavioral abnormalities in Huntington disease
C Ferrari Bardile, M Garcia-Miralles, NS Caron, NA Rayan, SR Langley, ...
Proceedings of the National Academy of Sciences 116 (19), 9622-9627, 2019
872019
Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease
M Garcia-Miralles, X Hong, LJ Tan, NS Caron, Y Huang, XV To, RY Lin, ...
Scientific reports 6 (1), 31652, 2016
722016
Lifeact cannot visualize some forms of stress-induced twisted F-actin
LN Munsie, N Caron, CR Desmond, R Truant
Nature methods 6 (5), 317-317, 2009
662009
Potent and sustained huntingtin lowering via AAV5 encoding miRNA preserves striatal volume and cognitive function in a humanized mouse model of Huntington disease
NS Caron, AL Southwell, CC Brouwers, LD Cengio, Y Xie, HF Black, ...
Nucleic acids research 48 (1), 36-54, 2020
602020
Interrupting sequence variants and age of onset in Huntington's disease: clinical implications and emerging therapies
GEB Wright, HF Black, JA Collins, T Gall-Duncan, NS Caron, CE Pearson, ...
The Lancet Neurology 19 (11), 930-939, 2020
542020
Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease
DE Ehrnhoefer, DDO Martin, ME Schmidt, X Qiu, S Ladha, NS Caron, ...
Acta neuropathologica communications 6, 1-16, 2018
532018
Mutant huntingtin is cleared from the brain via active mechanisms in Huntington disease
NS Caron, R Banos, C Yanick, AE Aly, LM Byrne, ED Smith, Y Xie, ...
Journal of Neuroscience 41 (4), 780-796, 2021
452021
Live cell imaging and biophotonic methods reveal two types of mutant huntingtin inclusions
NS Caron, CL Hung, RS Atwal, R Truant
Human molecular genetics 23 (9), 2324-2338, 2014
412014
Frequency of the loss of CAA interruption in the HTT CAG tract and implications for Huntington disease in the reduced penetrance range
HF Black, GEB Wright, JA Collins, N Caron, C Kay, Q Xia, L Arning, ...
Genetics in Medicine 22 (12), 2108-2113, 2020
392020
GeneReviews®
NS Caron, GEB Wright, MR Hayden, MP Adam, HH Ardinger, RA Pagon, ...
The National Center for Biotechnology Information, Seattle, WA, 2020
342020
Laquinimod decreases Bax expression and reduces caspase-6 activation in neurons
DE Ehrnhoefer, NS Caron, Y Deng, X Qiu, M Tsang, MR Hayden
Experimental neurology 283, 121-128, 2016
322016
The system can't perform the operation now. Try again later.
Articles 1–20