Lachlan Thompson
Lachlan Thompson
Theme Leader at Florey Institute for Neuroscience and Mental Health
Verified email at
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Hippocampal Lewy pathology and cholinergic dysfunction are associated with dementia in Parkinson’s disease
H Hall, S Reyes, N Landeck, C Bye, G Leanza, K Double, L Thompson, ...
Brain 137 (9), 2493-2508, 2014
Identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and …
L Thompson, P Barraud, E Andersson, D Kirik, A Björklund
Journal of Neuroscience 25 (27), 6467-6477, 2005
Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells
S Friling, E Andersson, LH Thompson, ME Jönsson, JB Hebsgaard, ...
Proceedings of the National Academy of Sciences 106 (18), 7613-7618, 2009
The A9 dopamine neuron component in grafts of ventral mesencephalon is an important determinant for recovery of motor function in a rat model of Parkinson’s disease
S Grealish, ME Jönsson, M Li, D Kirik, A Björklund, LH Thompson
Brain 133 (2), 482-495, 2010
Reconstruction of the nigrostriatal dopamine pathway in the adult mouse brain
LH Thompson, S Grealish, D Kirik, A Björklund
European Journal of Neuroscience 30 (4), 625-638, 2009
Peptide-based scaffolds support human cortical progenitor graft integration to reduce atrophy and promote functional repair in a model of stroke
FA Somaa, TY Wang, JC Niclis, KF Bruggeman, JA Kauhausen, H Guo, ...
Cell reports 20 (8), 1964-1977, 2017
GIRK2 expression in dopamine neurons of the substantia nigra and ventral tegmental area
S Reyes, Y Fu, K Double, L Thompson, D Kirik, G Paxinos, GM Halliday
Journal of Comparative Neurology 520 (12), 2591-2607, 2012
Birth dating of midbrain dopamine neurons identifies A9 enriched tissue for transplantation into parkinsonian mice
CR Bye, LH Thompson, CL Parish
Experimental neurology 236 (1), 58-68, 2012
Are stem cell-based therapies for Parkinson’s disease ready for the clinic in 2016?
RA Barker, M Parmar, A Kirkeby, A Björklund, L Thompson, P Brundin
Journal of Parkinson's disease 6 (1), 57-63, 2016
Identification of transplantable dopamine neuron precursors at different stages of midbrain neurogenesis
ME Jönsson, Y Ono, A Björklund, LH Thompson
Experimental neurology 219 (1), 341-354, 2009
Reconstruction of brain circuitry by neural transplants generated from pluripotent stem cells
LH Thompson, A Björklund
Neurobiology of disease 79, 28-40, 2015
Viral delivery of GDNF promotes functional integration of human stem cell grafts in Parkinson’s disease
CW Gantner, IR de Luzy, JA Kauhausen, N Moriarty, JC Niclis, CR Bye, ...
Cell Stem Cell 26 (4), 511-526. e5, 2020
Transcriptome analysis reveals transmembrane targets on transplantable midbrain dopamine progenitors
CR Bye, ME Jönsson, A Björklund, CL Parish, LH Thompson
Proceedings of the National Academy of Sciences 112 (15), E1946-E1955, 2015
Cometin is a novel neurotrophic factor that promotes neurite outgrowth and neuroblast migration in vitro and supports survival of spiral ganglion neurons in vivo
JR Jørgensen, A Fransson, L Fjord-Larsen, LH Thompson, JP Houchins, ...
Experimental Neurology 233 (1), 172-181, 2012
Neurogenin2 identifies a transplantable dopamine neuron precursor in the developing ventral mesencephalon
LH Thompson, E Andersson, JB Jensen, P Barraud, F Guillemot, ...
Experimental neurology 198 (1), 183-198, 2006
Glycogen synthase kinase 3β and activin/nodal inhibition in human embryonic stem cells induces a pre-neuroepithelial state that is required for specification to a floor plate …
M Denham, C Bye, J Leung, BJ Conley, LH Thompson, M Dottori
Stem cells 30 (11), 2400-2411, 2012
Isolation and characterization of neural precursor cells from the Sox1–GFP reporter mouse
P Barraud, L Thompson, D Kirik, A Björklund, M Parmar
European Journal of Neuroscience 22 (7), 1555-1569, 2005
Efficiently specified ventral midbrain dopamine neurons from human pluripotent stem cells under xeno-free conditions restore motor deficits in parkinsonian rodents
JC Niclis, CW Gantner, WF Alsanie, SJ McDougall, CR Bye, AG Elefanty, ...
Stem cells translational medicine 6 (3), 937-948, 2017
Neurons derived from human embryonic stem cells extend long-distance axonal projections through growth along host white matter tracts after intra-cerebral transplantation
M Denham, CL Parish, B Leaw, J Wright, CA Reid, S Petrou, M Dottori, ...
Frontiers in cellular neuroscience 6, 11, 2012
Trophic factors differentiate dopamine neurons vulnerable to Parkinson's disease
S Reyes, Y Fu, KL Double, V Cottam, LH Thompson, D Kirik, G Paxinos, ...
Neurobiology of aging 34 (3), 873-886, 2013
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