Nicholas Lyle
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Opposing effects of glutamine and asparagine govern prion formation by intrinsically disordered proteins
R Halfmann, S Alberti, R Krishnan, N Lyle, CW O'Donnell, OD King, ...
Molecular cell 43 (1), 72-84, 2011
Describing sequence–ensemble relationships for intrinsically disordered proteins
AH Mao, N Lyle, RV Pappu
Biochemical Journal 449 (2), 307-318, 2013
Quantitative assessments of the distinct contributions of polypeptide backbone amides versus side chain groups to chain expansion via chemical denaturation
AS Holehouse, K Garai, N Lyle, A Vitalis, RV Pappu
Journal of the American Chemical Society 137 (8), 2984-2995, 2015
Thermodynamics of β-sheet formation in polyglutamine
A Vitalis, N Lyle, RV Pappu
Biophysical Journal 97 (1), 303-311, 2009
Experiments and simulations show how long-range contacts can form in expanded unfolded proteins with negligible secondary structure
W Meng, N Lyle, B Luan, DP Raleigh, RV Pappu
Proceedings of the National Academy of Sciences 110 (6), 2123-2128, 2013
A quantitative measure for protein conformational heterogeneity
N Lyle, RK Das, RV Pappu
The Journal of chemical physics 139 (12), 2013
The denatured state ensemble contains significant local and long-range structure under native conditions: analysis of the N-terminal domain of ribosomal protein L9
W Meng, B Luan, N Lyle, RV Pappu, DP Raleigh
Biochemistry 52 (15), 2662-2671, 2013
Hamiltonian switch metropolis Monte Carlo simulations for improved conformational sampling of intrinsically disordered regions tethered to ordered domains of proteins
A Mittal, N Lyle, TS Harmon, RV Pappu
Journal of chemical theory and computation 10 (8), 3550-3562, 2014
Subcellular localization and Ser-137 phosphorylation regulate tumor-suppressive activity of profilin-1
MI Diamond, S Cai, A Boudreau, CJ Carey, N Lyle, RV Pappu, ...
Journal of Biological Chemistry 290 (14), 9075-9086, 2015
Denatured state ensembles with the same radii of gyration can form significantly different long-range contacts
B Luan, N Lyle, RV Pappu, DP Raleigh
Biochemistry 53 (1), 39-47, 2014
Alterations to the Conformational Ensemble and Intermolecular Associations of Polyglutamine Due to Charged Side Chains at the N-and C-Termini
NJ Lyle, SL Crick, RV Pappu
Biophysical Journal 100 (3), 63a, 2011
Inhibition of Nuclear Pfn1 by Ser-137 Phosphorylation
MI Diamond, S Cai, A Boudreau, CJ Carey Jr, N Lyle, RV Pappu, ...
Parsing the Contributions of Polypeptide Backbones and Sidechains to Denaturation in Concentrated Aqueous Solutions of Urea and Guanidinium Chloride
AS Holehouse, N Lyle, A Vitalis, D Thirumalai, RV Pappu
Biophysical Journal 106 (2), 484a, 2014
Coarse Grain Simulations Providing a Unifying Framework for Explaining Polyglutamine Aggregation Mechanism
S Khan, N Lyle, RV Pappu
Biophysical Journal 104 (2), 388a-389a, 2013
Modulation of Polyglutamine Conformations and Associations by C-Terminal Proline Rich Regions from Exon 1 of Huntingtin
K Ruff, N Lyle, RV Pappu
Biophysical Journal 104 (2), 233a, 2013
Quantifying Disorder using Simulated Ensembles for Different Classes of Polypeptides
NJ Lyle, RV Pappu
Biophysical Journal 104 (2), 53a, 2013
Quantification of conformational heterogeneity and its role in protein aggregation and unfolding
NJ Lyle
Washington University in St. Louis, 2013
Simulations of Denatured Protein Ensembles Reproduce and Rationalize Experimental Observations of Persistent Contacts Between Residues Distal in Protein Sequence
NJ Lyle, W Meng, DP Raleigh, RV Pappu
Biophysical Journal 102 (3), 630a, 2012
Implications Of Cis Interactions Between Expanded Polyglutamine and the Proline Rich C-Terminal Domain of Huntingtin Exon 1 For the Loss-Versus Gain-Of-Function Models of …
K Ruff, N Lyle, RV Pappu
Biophysical Journal 102 (3), 256a, 2012
Parameter Refinement, Optimization, and Extension of the Absinth Implicit Solvation Model
NJ Lyle, RV Pappu
Biophysical Journal 98 (3), 574a, 2010
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