| Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency P Mehdipour, SA Marhon, I Ettayebi, A Chakravarthy, A Hosseini, Y Wang, ... Nature 588 (7836), 169-173, 2020 | 179 | 2020 |
| An RB-EZH2 Complex Mediates Silencing of Repetitive DNA Sequences CA Ishak, AE Marshall, DT Passos, CR White, SJ Kim, MJ Cecchini, ... Molecular Cell 64 (6), 1074-1087, 2016 | 162 | 2016 |
| Endogenous retroelements and the viral mimicry response in cancer therapy and cellular homeostasis R Chen, CA Ishak, DD De Carvalho Cancer discovery 11 (11), 2707-2725, 2021 | 93 | 2021 |
| Haploinsufficiency of an RB–E2F1–Condensin II complex leads to aberrant replication and aneuploidy CH Coschi, CA Ishak, D Gallo, A Marshall, S Talluri, J Wang, MJ Cecchini, ... Cancer discovery 4 (7), 840-853, 2014 | 83 | 2014 |
| Deregulation of retroelements as an emerging therapeutic opportunity in cancer CA Ishak, M Classon, DD De Carvalho Trends in cancer 4 (8), 583-597, 2018 | 76 | 2018 |
| DNA hypomethylating agents increase activation and cytolytic activity of CD8+ T cells HL Yau, E Bell, I Ettayebi, FC de Almeida, GM Boukhaled, SY Shen, ... Molecular cell 81 (7), 1469-1483. e8, 2021 | 66 | 2021 |
| An open-label, phase II multicohort study of an oral hypomethylating agent CC-486 and durvalumab in advanced solid tumors K Taylor, HL Yau, A Chakravarthy, B Wang, SY Shen, I Ettayebi, CA Ishak, ... Journal for immunotherapy of cancer 8 (2), 2020 | 49 | 2020 |
| Reactivation of endogenous retroelements in cancer development and therapy CA Ishak, DD De Carvalho Annual Review of Cancer Biology 4 (1), 159-176, 2020 | 46 | 2020 |
| Loss of the mammalian DREAM complex deregulates chondrocyte proliferation C Forristal, SA Henley, JI MacDonald, JR Bush, C Ort, DT Passos, ... Molecular and cellular biology 34 (12), 2221-2234, 2014 | 38 | 2014 |
| Modeling methyl-sensitive transcription factor motifs with an expanded epigenetic alphabet C Viner, CA Ishak, J Johnson, NJ Walker, H Shi, MK Sjöberg-Herrera, ... Genome biology 25 (1), 11, 2024 | 27 | 2024 |
| Haploinsufficiency of RREB1 causes a Noonan-like RASopathy via epigenetic reprogramming of RAS-MAPK pathway genes OA Kent, M Saha, E Coyaud, HE Burston, N Law, K Dadson, S Chen, ... Nature communications 11 (1), 4673, 2020 | 21 | 2020 |
| Disruption of CDK-resistant chromatin association by pRB causes DNA damage, mitotic errors, and reduces Condensin II recruitment CA Ishak, CH Coschi, MV Roes, FA Dick Cell Cycle 16 (15), 1430-1439, 2017 | 20 | 2017 |
| Loss of the retinoblastoma tumor suppressor correlates with improved outcome in patients with lung adenocarcinoma treated with surgery and chemotherapy MJ Cecchini, CA Ishak, DT Passos, A Warner, DA Palma, CJ Howlett, ... Human Pathology 46 (12), 1922-1934, 2015 | 17 | 2015 |
| DNA methylation as a robust classifier of epithelial ovarian cancer CA Ishak, S Lheureux, DD De Carvalho Clinical Cancer Research 25 (19), 5729-5731, 2019 | 12 | 2019 |
| An RB-condensin II complex mediates long-range chromosome interactions and influences expression at divergently paired genes AE Marshall, CA Ishak, FA Dick Molecular and cellular biology, 2020 | 11 | 2020 |
| Spliceosome-targeted therapies induce dsRNA responses CA Ishak, HL Yau, DD De Carvalho Immunity 54 (1), 11-13, 2021 | 10 | 2021 |
| Conditional haploinsufficiency of the retinoblastoma tumor suppressor gene CA Ishak, FA Dick Molecular & Cellular Oncology 2 (1), e968069, 2015 | 9 | 2015 |
| Publisher Correction: Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency (Nature,(2020), 588, 7836,(169-173), 10.1038/s41586-020-2844-1) P Mehdipour, SA Marhon, I Ettayebi, A Chakravarthy, A Hosseini, Y Wang, ... Nature 591 (7850), E20, 2021 | 5 | 2021 |
| DNA methylation profiling of premalignant lesions as a path to ovarian cancer early detection CA Ishak, DD De Carvalho Clinical Cancer Research 26 (23), 6083-6085, 2020 | 4 | 2020 |
| Retroelement decay by the exonuclease XRN1 is a viral mimicry dependency in cancer A Hosseini, HT Lindholm, R Chen, P Mehdipour, SA Marhon, CA Ishak, ... Cell Reports 43 (2), 2024 | 2 | 2024 |
Daniel De CarvalhoProfessor, University of Toronto. Senior Scientist, Princess Margaret Cancer CentreVerified email at uhnresearch.ca
