Calorie restriction and aging: a life‐history analysis DP Shanley, TBL Kirkwood Evolution 54 (3), 740-750, 2000 | 364 | 2000 |
An evolutionary perspective on the mechanisms of immunosenescence DP Shanley, D Aw, NR Manley, DB Palmer Trends in immunology 30 (7), 374-381, 2009 | 326 | 2009 |
Food restriction, evolution and ageing TBL Kirkwood, DP Shanley Mechanisms of ageing and development 126 (9), 1011-1016, 2005 | 185 | 2005 |
Evolution of the human menopause DP Shanley, TBL Kirkwood Bioessays 23 (3), 282-287, 2001 | 177 | 2001 |
A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulation P Dalle Pezze, AG Sonntag, A Thien, MT Prentzell, M Godel, S Fischer, ... Science signaling 5 (217), ra25, 2012 | 173 | 2012 |
Dynamic modelling of pathways to cellular senescence reveals strategies for targeted interventions P Dalle Pezze, G Nelson, EG Otten, VI Korolchuk, TBL Kirkwood, ... PLoS Comput Biol 10 (8), e1003728, 2014 | 169 | 2014 |
Testing evolutionary theories of menopause DP Shanley, R Sear, R Mace, TBL Kirkwood Proceedings of the Royal Society B: Biological Sciences 274 (1628), 2943-2949, 2007 | 164 | 2007 |
A systems study reveals concurrent activation of AMPK and mTOR by amino acids P Dalle Pezze, S Ruf, AG Sonntag, M Langelaar-Makkinje, P Hall, ... Nature communications 7, 13254, 2016 | 160 | 2016 |
Towards an e-biology of ageing: integrating theory and data TBL Kirkwood, RJ Boys, CS Gillespie, CJ Proctor, DP Shanley, ... Nature Reviews Molecular Cell Biology 4 (3), 243-249, 2003 | 138 | 2003 |
Evolution, stress, and longevity TBL Kirkwood, P Kapahi, DP Shanley Journal of anatomy 197 (04), 587-590, 2000 | 128 | 2000 |
Glutathione peroxidase 4 has a major role in protecting mitochondria from oxidative damage and maintaining oxidative phosphorylation complexes in gut epithelial cells P Cole-Ezea, D Swan, D Shanley, J Hesketh Free Radical Biology and Medicine 53 (3), 488-497, 2012 | 109 | 2012 |
Caloric restriction does not enhance longevity in all species and is unlikely to do so in humans DP Shanley, TBL Kirkwood Biogerontology 7 (3), 165-168, 2006 | 106 | 2006 |
Modelling the actions of chaperones and their role in ageing CJ Proctor, C Sőti, RJ Boys, CS Gillespie, DP Shanley, DJ Wilkinson, ... Mechanisms of ageing and development 126 (1), 119-131, 2005 | 102 | 2005 |
Genome‐Wide MicroRNA and Gene Analysis of Mesenchymal Stem Cell Chondrogenesis Identifies an Essential Role and Multiple Targets for miR‐140‐5p MJ Barter, M Tselepi, R Gómez, S Woods, W Hui, GR Smith, DP Shanley, ... Stem Cells 33 (11), 3266-3280, 2015 | 91 | 2015 |
A modelling–experimental approach reveals insulin receptor substrate (IRS)‐dependent regulation of adenosine monosphosphate‐dependent kinase (AMPK) by insulin AG Sonntag, P Dalle Pezze, DP Shanley, K Thedieck FEBS Journal 279 (18), 3314-3328, 2012 | 73 | 2012 |
A stochastic step model of replicative senescence explains ROS production rate in ageing cell populations C Lawless, D Jurk, CS Gillespie, D Shanley, G Saretzki, T von Zglinicki, ... PloS one 7 (2), e32117, 2012 | 70 | 2012 |
The connections between general and reproductive senescence and the evolutionary basis of menopause TBL Kirkwood, DP Shanley Annals of the New York Academy of Sciences 1204 (1), 21-29, 2010 | 67 | 2010 |
The fitness of twin mothers: evidence from rural Gambia R Sear, D Shanley, IA McGregor, R Mace Journal of Evolutionary Biology 14 (3), 433-443, 2001 | 62 | 2001 |
The predictive adaptive response: Modeling the life-history evolution of the butterfly Bicyclus anynana in seasonal environments J van den Heuvel, M Saastamoinen, PM Brakefield, TBL Kirkwood, ... The American Naturalist 181 (2), E28-E42, 2013 | 55 | 2013 |
Modelling the response of FOXO transcription factors to multiple post-translational modifications made by ageing-related signalling pathways GR Smith, DP Shanley PLoS One 5 (6), e11092, 2010 | 55 | 2010 |