| Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL WJ Kaiser, H Sridharan, C Huang, P Mandal, JW Upton, PJ Gough, ... Journal of Biological Chemistry 288 (43), 31268-31279, 2013 | 917 | 2013 |
| MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates Y Dondelinger, W Declercq, S Montessuit, R Roelandt, A Goncalves, ... Cell reports 7 (4), 971-981, 2014 | 815 | 2014 |
| Tumor necrosis factor-α-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1) KJ Garton, PJ Gough, CP Blobel, G Murphy, DR Greaves, PJ Dempsey, ... Journal of Biological Chemistry 276 (41), 37993-38001, 2001 | 784 | 2001 |
| Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death P Orning, D Weng, K Starheim, D Ratner, Z Best, B Lee, A Brooks, S Xia, ... Science 362 (6418), 1064-1069, 2018 | 743 | 2018 |
| RIP3 induces apoptosis independent of pronecrotic kinase activity P Mandal, SB Berger, S Pillay, K Moriwaki, C Huang, H Guo, JD Lich, ... Molecular cell 56 (4), 481-495, 2014 | 567 | 2014 |
| Macrophage expression of active MMP-9 induces acute plaque disruption in apoE-deficient mice PJ Gough, IG Gomez, PT Wille, EW Raines The Journal of clinical investigation 116 (1), 59-69, 2006 | 560 | 2006 |
| Design of amidobenzimidazole STING receptor agonists with systemic activity JM Ramanjulu, GS Pesiridis, J Yang, N Concha, R Singhaus, SY Zhang, ... Nature 564 (7736), 439-443, 2018 | 559 | 2018 |
| Neuronal death after hemorrhagic stroke in vitro and in vivo shares features of ferroptosis and necroptosis M Zille, SS Karuppagounder, Y Chen, PJ Gough, J Bertin, J Finger, ... Stroke 48 (4), 1033-1043, 2017 | 425 | 2017 |
| NF-κB-independent role of IKKα/IKKβ in preventing RIPK1 kinase-dependent apoptotic and necroptotic cell death during TNF signaling Y Dondelinger, S Jouan-Lanhouet, T Divert, E Theatre, J Bertin, PJ Gough, ... Molecular cell 60 (1), 63-76, 2015 | 422 | 2015 |
| Discovery of a first-in-class receptor interacting protein 1 (RIP1) kinase specific clinical candidate (GSK2982772) for the treatment of inflammatory diseases PA Harris, SB Berger, JU Jeong, R Nagilla, D Bandyopadhyay, ... Journal of medicinal chemistry 60 (4), 1247-1261, 2017 | 416 | 2017 |
| Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice SB Berger, V Kasparcova, S Hoffman, B Swift, L Dare, M Schaeffer, ... The Journal of Immunology 192 (12), 5476-5480, 2014 | 385 | 2014 |
| RIPK3 activates parallel pathways of MLKL-driven necroptosis and FADD-mediated apoptosis to protect against influenza A virus S Nogusa, RJ Thapa, CP Dillon, S Liedmann, TH Oguin, JP Ingram, ... Cell host & microbe 20 (1), 13-24, 2016 | 341 | 2016 |
| Stimulated shedding of vascular cell adhesion molecule 1 (VCAM-1) is mediated by tumor necrosis factor-α-converting enzyme (ADAM 17) KJ Garton, PJ Gough, J Philalay, PT Wille, CP Blobel, RH Whitehead, ... Journal of Biological Chemistry 278 (39), 37459-37464, 2003 | 340 | 2003 |
| RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis N Takahashi, L Vereecke, MJM Bertrand, L Duprez, SB Berger, T Divert, ... Nature 513 (7516), 95-99, 2014 | 325 | 2014 |
| Macrophage Class A Scavenger Receptor-Mediated Phagocytosis of Escherichia coli: Role of Cell Heterogeneity, Microbial Strain, and Culture Conditions In Vitro L Peiser, PJ Gough, T Kodama, S Gordon Infection and immunity 68 (4), 1953-1963, 2000 | 322 | 2000 |
| A disintegrin and metalloproteinase 10-mediated cleavage and shedding regulates the cell surface expression of CXC chemokine ligand 16 PJ Gough, KJ Garton, PT Wille, M Rychlewski, PJ Dempsey, EW Raines The Journal of Immunology 172 (6), 3678-3685, 2004 | 321 | 2004 |
| Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death D Weng, R Marty-Roix, S Ganesan, MK Proulx, GI Vladimer, WJ Kaiser, ... Proceedings of the National Academy of Sciences 111 (20), 7391-7396, 2014 | 314 | 2014 |
| RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition WJ Kaiser, LP Daley-Bauer, RJ Thapa, P Mandal, SB Berger, C Huang, ... Proceedings of the National Academy of Sciences 111 (21), 7753-7758, 2014 | 305 | 2014 |
| Emerging roles for ectodomain shedding in the regulation of inflammatory responses KJ Garton, PJ Gough, EW Raines Journal of leukocyte biology 79 (6), 1105-1116, 2006 | 291 | 2006 |
| Autolytic proteolysis within the function to find domain (FIIND) is required for NLRP1 inflammasome activity JN Finger, JD Lich, LC Dare, MN Cook, KK Brown, C Duraiswami, ... Journal of Biological Chemistry 287 (30), 25030-25037, 2012 | 280 | 2012 |
