Peter Gough
Peter Gough
Inzen Therapeutics
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Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL
WJ Kaiser, H Sridharan, C Huang, P Mandal, JW Upton, PJ Gough, ...
Journal of Biological Chemistry 288 (43), 31268-31279, 2013
Tumor necrosis factor-α-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1)
KJ Garton, PJ Gough, CP Blobel, G Murphy, DR Greaves, PJ Dempsey, ...
Journal of Biological Chemistry 276 (41), 37993-38001, 2001
MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates
Y Dondelinger, W Declercq, S Montessuit, R Roelandt, A Goncalves, ...
Cell reports 7 (4), 971-981, 2014
Macrophage expression of active MMP-9 induces acute plaque disruption in apoE-deficient mice
PJ Gough, IG Gomez, PT Wille, EW Raines
The Journal of clinical investigation 116 (1), 59-69, 2006
Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death
P Orning, D Weng, K Starheim, D Ratner, Z Best, B Lee, A Brooks, S Xia, ...
Science 362 (6418), 1064-1069, 2018
RIP3 induces apoptosis independent of pronecrotic kinase activity
P Mandal, SB Berger, S Pillay, K Moriwaki, C Huang, H Guo, JD Lich, ...
Molecular cell 56 (4), 481-495, 2014
Design of amidobenzimidazole STING receptor agonists with systemic activity
JM Ramanjulu, GS Pesiridis, J Yang, N Concha, R Singhaus, SY Zhang, ...
Nature 564 (7736), 439-443, 2018
NF-κB-independent role of IKKα/IKKβ in preventing RIPK1 kinase-dependent apoptotic and necroptotic cell death during TNF signaling
Y Dondelinger, S Jouan-Lanhouet, T Divert, E Theatre, J Bertin, PJ Gough, ...
Molecular cell 60 (1), 63-76, 2015
Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice
SB Berger, V Kasparcova, S Hoffman, B Swift, L Dare, M Schaeffer, ...
The Journal of Immunology 192 (12), 5476-5480, 2014
Neuronal death after hemorrhagic stroke in vitro and in vivo shares features of ferroptosis and necroptosis
M Zille, SS Karuppagounder, Y Chen, PJ Gough, J Bertin, J Finger, ...
Stroke 48 (4), 1033-1043, 2017
Stimulated shedding of vascular cell adhesion molecule 1 (VCAM-1) is mediated by tumor necrosis factor-α-converting enzyme (ADAM 17)
KJ Garton, PJ Gough, J Philalay, PT Wille, CP Blobel, RH Whitehead, ...
Journal of Biological Chemistry 278 (39), 37459-37464, 2003
Macrophage Class A Scavenger Receptor-Mediated Phagocytosis of Escherichia coli: Role of Cell Heterogeneity, Microbial Strain, and Culture Conditions In Vitro
L Peiser, PJ Gough, T Kodama, S Gordon
Infection and immunity 68 (4), 1953-1963, 2000
A disintegrin and metalloproteinase 10-mediated cleavage and shedding regulates the cell surface expression of CXC chemokine ligand 16
PJ Gough, KJ Garton, PT Wille, M Rychlewski, PJ Dempsey, EW Raines
The Journal of Immunology 172 (6), 3678-3685, 2004
Discovery of a first-in-class receptor interacting protein 1 (RIP1) kinase specific clinical candidate (GSK2982772) for the treatment of inflammatory diseases
PA Harris, SB Berger, JU Jeong, R Nagilla, D Bandyopadhyay, ...
Journal of medicinal chemistry 60 (4), 1247-1261, 2017
RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis
N Takahashi, L Vereecke, MJM Bertrand, L Duprez, SB Berger, T Divert, ...
Nature 513 (7516), 95-99, 2014
Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death
D Weng, R Marty-Roix, S Ganesan, MK Proulx, GI Vladimer, WJ Kaiser, ...
Proceedings of the National Academy of Sciences 111 (20), 7391-7396, 2014
Emerging roles for ectodomain shedding in the regulation of inflammatory responses
KJ Garton, PJ Gough, EW Raines
Journal of leukocyte biology 79 (6), 1105-1116, 2006
RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition
WJ Kaiser, LP Daley-Bauer, RJ Thapa, P Mandal, SB Berger, C Huang, ...
Proceedings of the National Academy of Sciences 111 (21), 7753-7758, 2014
RIPK3 activates parallel pathways of MLKL-driven necroptosis and FADD-mediated apoptosis to protect against influenza A virus
S Nogusa, RJ Thapa, CP Dillon, S Liedmann, TH Oguin III, JP Ingram, ...
Cell host & microbe 20 (1), 13-24, 2016
The role of scavenger receptors in the innate immune system
PJ Gough, S Gordon
Microbes and Infection 2 (3), 305-311, 2000
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