Martin Duennwald
Martin Duennwald
University of Western Ontario
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Green tea (−)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models
DE Ehrnhoefer, M Duennwald, P Markovic, JL Wacker, S Engemann, ...
Human molecular genetics 15 (18), 2743-2751, 2006
A chaperone pathway in protein disaggregation: Hsp26 alters the nature of protein aggregates to facilitate reactivation by Hsp104
AG Cashikar, M Duennwald, SL Lindquist
Journal of Biological Chemistry 280 (25), 23869-23875, 2005
Flanking sequences profoundly alter polyglutamine toxicity in yeast
ML Duennwald, S Jagadish, PJ Muchowski, S Lindquist
Proceedings of the National Academy of Sciences 103 (29), 11045-11050, 2006
Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity
ML Duennwald, S Lindquist
Genes & development 22 (23), 3308-3319, 2008
The Hsp70/Hsp90 chaperone machinery in neurodegenerative diseases
RE Lackie, A Maciejewski, VG Ostapchenko, J Marques-Lopes, WY Choy, ...
Frontiers in neuroscience 11, 254, 2017
Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single-domain intracellular antibody
DW Colby, YJ Chu, JP Cassady, M Duennwald, H Zazulak, JM Webster, ...
Proceedings of the National Academy of Sciences 101 (51), 17616-17621, 2004
Small heat shock proteins potentiate amyloid dissolution by protein disaggregases from yeast and humans
ML Duennwald, AL Echeverria, J Shorter
PLoS biology 10 (6), e1001346, 2012
Chaperone-dependent amyloid assembly protects cells from prion toxicity
PM Douglas, S Treusch, HY Ren, R Halfmann, ML Duennwald, ...
Proceedings of the National Academy of Sciences 105 (20), 7206-7211, 2008
A network of protein interactions determines polyglutamine toxicity
ML Duennwald, S Jagadish, F Giorgini, PJ Muchowski, S Lindquist
Proceedings of the National Academy of Sciences 103 (29), 11051-11056, 2006
A synergistic small-molecule combination directly eradicates diverse prion strain structures
BE Roberts, ML Duennwald, H Wang, C Chung, NP Lopreiato, ...
Nature chemical biology 5 (12), 936-946, 2009
Detection of transient in vivo interactions between substrate and transporter during protein translocation into the endoplasmic reticulum
M Dunnwald, A Varshavsky, N Johnsson
Molecular Biology of the Cell 10 (2), 329-344, 1999
Direct and selective elimination of specific prions and amyloids by 4, 5-dianilinophthalimide and analogs
H Wang, ML Duennwald, BE Roberts, LM Rozeboom, YL Zhang, ...
Proceedings of the National Academy of Sciences 105 (20), 7159-7164, 2008
Impaired heat shock response in cells expressing full-length polyglutamine-expanded huntingtin
SM Chafekar, ML Duennwald
PloS one 7 (5), e37929, 2012
Sec62p, a component of the endoplasmic reticulum protein translocation machinery, contains multiple binding sites for the Sec-complex
S Wittke, M Dunnwald, N Johnsson
Molecular biology of the cell 11 (11), 3859-3871, 2000
Recognition of a Subset of Signal Sequences by Ssh1p, a Sec61p-related Protein in the Membrane of Endoplasmic Reticulum of Yeast Saccharomyces cerevisiae
S Wittke, M Dunnwald, M Albertsen, N Johnsson
Molecular biology of the cell 13 (7), 2223-2232, 2002
Polyglutamine expanded huntingtin dramatically alters the genome-wide binding of HSF1
L Riva, M Koeva, F Yildirim, L Pirhaji, D Dinesh, T Mazor, ML Duennwald, ...
Journal of Huntington's disease 1 (1), 33-45, 2012
Pharmacological tuning of heat shock protein 70 modulates polyglutamine toxicity and aggregation
SM Chafekar, S Wisén, AD Thompson, AL Echeverria, GM Walter, ...
ACS chemical biology 7 (9), 1556-1564, 2012
Ordered assembly of heat shock proteins, Hsp26, Hsp70, Hsp90, and Hsp104, on expanded polyglutamine fragments revealed by chemical probes
GM Walter, MC Smith, S Wisén, V Basrur, KSJ Elenitoba-Johnson, ...
Journal of Biological Chemistry 286 (47), 40486-40493, 2011
Polyglutamine misfolding in yeast: toxic and protective aggregation
ML Duennwald
Prion 5 (4), 285-290, 2011
Visualizing tRNA-dependent mistranslation in human cells
JT Lant, MD Berg, DHW Sze, KS Hoffman, IC Akinpelu, MA Turk, ...
RNA biology 15 (4-5), 567-575, 2018
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