Shawn French
Shawn French
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A deep learning approach to antibiotic discovery
JM Stokes, K Yang, K Swanson, W Jin, A Cubillos-Ruiz, NM Donghia, ...
Cell 180 (4), 688-702. e13, 2020
Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance
JM Stokes, CR MacNair, B Ilyas, S French, JP Côté, C Bouwman, ...
Nature microbiology 2 (5), 1-8, 2017
Assembly and clustering of natural antibiotics guides target identification
CW Johnston, MA Skinnider, CA Dejong, PN Rees, GM Chen, CG Walker, ...
Nature chemical biology 12 (4), 233-239, 2016
Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase
MA Farha, TL Czarny, CL Myers, LJ Worrall, S French, DG Conrady, ...
Proceedings of the National Academy of Sciences 112 (35), 11048-11053, 2015
Elevated temperatures and carbon dioxide concentrations: effects on selected microbial activities in temperate agricultural soils
S French, D Levy-Booth, A Samarajeewa, KE Shannon, J Smith, ...
World Journal of Microbiology and Biotechnology 25 (11), 1887-1900, 2009
Bicarbonate alters bacterial susceptibility to antibiotics by targeting the proton motive force
MA Farha, S French, J Stokes, ED Brown
ACS infectious diseases, 2018
Structural and kinetic characterization of diazabicyclooctanes as dual inhibitors of both serine-β-lactamases and penicillin-binding proteins
AM King, DT King, S French, E Brouillette, A Asli, JAN Alexander, ...
ACS chemical biology 11 (4), 864-868, 2016
Cold Stress Makes Escherichia coli Susceptible to Glycopeptide Antibiotics by Altering Outer Membrane Integrity
JM Stokes, S French, OG Ovchinnikova, C Bouwman, C Whitfield, ...
Cell chemical biology 23 (2), 267-277, 2016
A robust platform for chemical genomics in bacterial systems
S French, C Mangat, A Bharat, JP Côté, H Mori, ED Brown
Molecular biology of the cell 27 (6), 1015-1025, 2016
Discovery of Novel Cell Wall-Active Compounds Using PywaC, a Sensitive Reporter of Cell Wall Stress, in the Model Gram-Positive Bacterium Bacillus subtilis
TL Czarny, AL Perri, S French, ED Brown
Antimicrobial Agents and Chemotherapy 58 (6), 3261-3269, 2014
The genome-wide interaction network of nutrient stress genes in Escherichia coli
JP Côté, S French, SS Gehrke, CR MacNair, CS Mangat, A Bharat, ...
MBio 7 (6), e01714-16, 2016
The dynamic nature of bacterial surfaces: Implications for metal-membrane interaction
S French, D Puddephatt, M Habash, S Glasauer
Critical Reviews in Microbiology 39 (2), 196-217, 2013
A multiplexable assay for screening antibiotic lethality against drug-tolerant bacteria
JM Stokes, A Gutierrez, AJ Lopatkin, IW Andrews, S French, I Matic, ...
Nature methods 16 (4), 303-306, 2019
Bacteria Getting into Shape: Genetic Determinants of E. coli Morphology
S French, JP Côté, JM Stokes, R Truant, ED Brown
MBio 8 (2), e01977-16, 2017
Identification of two phosphate starvation-induced wall teichoic acid hydrolases provides first insights into the degradative pathway of a key bacterial cell wall component
CL Myers, FKK Li, BM Koo, OM El-Halfawy, S French, CA Gross, ...
Journal of Biological Chemistry 291 (50), 26066-26082, 2016
A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium
MJ Ellis, CN Tsai, JW Johnson, S French, W Elhenawy, S Porwollik, ...
Nature communications 10 (1), 1-14, 2019
Potentiation of antibiotics against Gram-negative bacteria by polymyxin B analogue SPR741 from unique perturbation of the outer membrane
S French, M Farha, MJ Ellis, Z Sameer, JP Côté, N Cotroneo, T Lister, ...
ACS infectious diseases 6 (6), 1405-1412, 2019
Open-source high-throughput phenomics of bacterial promoter-reporter strains
S French, BE Coutts, ED Brown
Cell systems 7 (3), 339-346. e3, 2018
Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance. Nat Microbiol 2: 17028
JM Stokes, CR MacNair, B Ilyas, S French, JP Côté, C Bouwman, ...
Genetic and chemical-genetic interactions map biogenesis and permeability determinants of the outer membrane of Escherichia coli
K Klobucar, S French, JP Côté, JR Howes, ED Brown
MBio 11 (2), e00161-20, 2020
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