|A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function|
S Feske, Y Gwack, M Prakriya, S Srikanth, SH Puppel, B Tanasa, ...
Nature 441 (7090), 179-185, 2006
|Orai1 is an essential pore subunit of the CRAC channel|
M Prakriya, S Feske, Y Gwack, S Srikanth, A Rao, PG Hogan
Nature 443 (7108), 230-233, 2006
|A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT|
Y Gwack, S Sharma, J Nardone, B Tanasa, A Iuga, S Srikanth, H Okamura, ...
Nature 441 (7093), 646-650, 2006
|Biochemical and functional characterization of Orai proteins|
Y Gwack, S Srikanth, S Feske, F Cruz-Guilloty, M Oh-hora, DS Neems, ...
Journal of Biological Chemistry 282 (22), 16232-16243, 2007
|Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx: evidence for similarities in store-operated and calcium release-activated …|
HL Ong, KT Cheng, X Liu, BC Bandyopadhyay, BC Paria, J Soboloff, ...
Journal of Biological Chemistry 282 (12), 9105-9116, 2007
|Signalling to transcription: store-operated Ca2+ entry and NFAT activation in lymphocytes|
Y Gwack, S Feske, S Srikanth, PG Hogan, A Rao
Cell calcium 42 (2), 145-156, 2007
|Hair loss and defective T-and B-cell function in mice lacking ORAI1|
Y Gwack, S Srikanth, M Oh-Hora, PG Hogan, ED Lamperti, M Yamashita, ...
Molecular and cellular biology 28 (17), 5209-5222, 2008
|A novel EF-hand protein, CRACR2A, is a cytosolic Ca 2+ sensor that stabilizes CRAC channels in T cells|
S Srikanth, HJ Jung, KD Kim, P Souda, J Whitelegge, Y Gwack
Nature cell biology 12 (5), 436-446, 2010
|The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4+ T cells|
S Bertin, Y Aoki-Nonaka, PR De Jong, LL Nohara, H Xu, SR Stanwood, ...
Nature immunology 15 (11), 1055-1063, 2014
|Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: puncta and distal caps|
VA Barr, KM Bernot, S Srikanth, Y Gwack, L Balagopalan, CK Regan, ...
Molecular biology of the cell 19 (7), 2802-2817, 2008
|Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1)|
S Srikanth, M Jew, KD Kim, MK Yee, J Abramson, Y Gwack
Proceedings of the National Academy of Sciences 109 (22), 8682-8687, 2012
|The Ca 2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum|
S Srikanth, JS Woo, B Wu, YM El-Sherbiny, J Leung, K Chupradit, L Rice, ...
Nature immunology 20 (2), 152-162, 2019
|Orai1-NFAT signalling pathway triggered by T cell receptor stimulation|
S Srikanth, Y Gwack
Molecules and cells 35 (3), 182-194, 2013
|Interplay between the oxidoreductase PDIA6 and microRNA-322 controls the response to disrupted endoplasmic reticulum calcium homeostasis|
J Groenendyk, Z Peng, E Dudek, X Fan, MJ Mizianty, E Dufey, H Urra, ...
Science signaling 7 (329), ra54-ra54, 2014
|The intracellular loop of Orai1 plays a central role in fast inactivation of Ca2+ release-activated Ca2+ channels|
S Srikanth, HJ Jung, B Ribalet, Y Gwack
Journal of Biological Chemistry 285 (7), 5066-5075, 2010
|Laminar flow downregulates Notch activity to promote lymphatic sprouting|
D Choi, E Park, E Jung, YJ Seong, J Yoo, E Lee, M Hong, S Lee, H Ishida, ...
The Journal of clinical investigation 127 (4), 1225-1240, 2017
|ORAI1 deficiency impairs activated T cell death and enhances T cell survival|
KD Kim, S Srikanth, MKW Yee, DC Mock, GW Lawson, Y Gwack
The Journal of Immunology 187 (7), 3620-3630, 2011
|Orai1, STIM1, and their associating partners|
S Srikanth, Y Gwack
The Journal of physiology 590 (17), 4169-4177, 2012
|Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation|
KD Kim, S Srikanth, YV Tan, MK Yee, M Jew, R Damoiseaux, ME Jung, ...
The Journal of Immunology 192 (1), 110-122, 2014
|Junctophilin-4, a component of the endoplasmic reticulum–plasma membrane junctions, regulates Ca2+ dynamics in T cells|
JS Woo, S Srikanth, M Nishi, P Ping, H Takeshima, Y Gwack
Proceedings of the National Academy of Sciences 113 (10), 2762-2767, 2016