Élie Besserer-Offroy
Élie Besserer-Offroy
Assistant Professor, Department of Molecular and Medical Pharmacology, UCLA
Verified email at ucla.edu - Homepage
Cited by
Cited by
Elucidation of the structure–activity relationships of apelin: influence of unnatural amino acids on binding, signaling, and plasma stability
A Murza, A Parent, E Besserer‐Offroy, H Tremblay, F Karadereye, ...
ChemMedChem 7 (2), 318-325, 2012
Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties
M Demeule, N Beaudet, A Régina, É Besserer-Offroy, A Murza, ...
The Journal of clinical investigation 124 (3), 1199-1213, 2014
Discovery and structure–activity relationship of a bioactive fragment of ELABELA that modulates vascular and cardiac functions
A Murza, X Sainsily, D Coquerel, J Cote, P Marx, É Besserer-Offroy, ...
Journal of medicinal chemistry 59 (7), 2962-2972, 2016
C-Terminal modifications of apelin-13 significantly change ligand binding, receptor signaling, and hypotensive action
A Murza, E Besserer-Offroy, J Cote, P Berube, JM Longpre, R Dumaine, ...
Journal of medicinal chemistry 58 (5), 2431-2440, 2015
The signaling signature of the neurotensin type 1 receptor with endogenous ligands
É Besserer-Offroy, RL Brouillette, S Lavenus, U Froehlich, A Brumwell, ...
European journal of pharmacology 805, 1-13, 2017
Synthesis, in vitro and in vivo characterization of (L)-(trimethylsilyl) alanine containing neurotensin analogues
R Fanelli, É Besserer-Offroy, A René, J Côté, P Tétrault, ...
Journal of Medicinal Chemistry, 2015
Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs
A Luginina, A Gusach, E Marin, A Mishin, R Brouillette, P Popov, ...
Science advances 5 (10), eaax2518, 2019
Structure–activity relationship of novel macrocyclic biased apelin receptor agonists
A Murza, X Sainsily, J Côté, L Bruneau-Cossette, É Besserer-Offroy, ...
Organic & biomolecular chemistry 15 (2), 449-458, 2017
Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors
A Gusach, A Luginina, E Marin, RL Brouillette, É Besserer-Offroy, ...
Nature communications 10 (1), 1-9, 2019
Stereoselective Synthesis of β‐(5‐Arylthiazolyl) α‐Amino Acids and Use in Neurotensin Analogues
D Hapău, E Rémond, R Fanelli, M Vivancos, A René, J Côté, ...
European Journal of Organic Chemistry 2016 (5), 1017-1024, 2016
Design, synthesis, and biological evaluation of CXCR4 ligands
CE Mona, É Besserer-Offroy, J Cabana, R Leduc, P Lavigne, N Heveker, ...
Organic & biomolecular chemistry 14 (43), 10298-10311, 2016
Structural optimization and characterization of potent analgesic macrocyclic analogues of neurotensin (8–13)
M Sousbie, M Vivancos, RL Brouillette, E Besserer-Offroy, JM Longpré, ...
Journal of medicinal chemistry 61 (16), 7103-7115, 2018
Use of molecular modeling to design selective NTS2 neurotensin analogues
R Fanelli, N Floquet, E Besserer-Offroy, B Delort, M Vivancos, JM Longpre, ...
Journal of medicinal chemistry 60 (8), 3303-3313, 2017
The hypotensive effect of activated apelin receptor is correlated with β-arrestin recruitment
É Besserer-Offroy, P Bérubé, J Côté, A Murza, JM Longpré, R Dumaine, ...
Pharmacological research 131, 7-16, 2018
Identification of 2-({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)tricyclo[,7]decane-2-carboxylic Acid (NTRC-844) as a …
JB Thomas, M Vivancos, AM Giddings, RW Wiethe, KR Warner, A Murza, ...
ACS chemical neuroscience 7 (9), 1225-1231, 2016
Angiotensin II cyclic analogs as tools to investigate AT1R biased signaling mechanisms
D St-Pierre, J Cabana, BJ Holleran, É Besserer-Offroy, E Escher, ...
Biochemical pharmacology 154, 104-117, 2018
Structure–activity relationship and signaling of new chimeric CXCR4 agonists
CE Mona, E Besserer-Offroy, J Cabana, M Lefrançois, PE Boulais, ...
Journal of medicinal chemistry 59 (16), 7512-7524, 2016
Apelin-13 regulates vasopressin-induced aquaporin-2 expression and trafficking in kidney collecting duct cells
C Boulkeroua, H Ayari, T Khalfaoui, M Lafrance, É Besserer-Offroy, ...
Cell Physiol Biochem 53, 687-700, 2019
In search of the optimal macrocyclization site for neurotensin
M Sousbie, É Besserer-Offroy, RL Brouillette, JM Longpré, R Leduc, ...
ACS medicinal chemistry letters 9 (3), 227-232, 2018
Pain relief devoid of opioid side effects following central action of a silylated neurotensin analog
P Tétreault, É Besserer-Offroy, R Brouillette, A René, A Murza, R Fanelli, ...
European Journal of Pharmacology, 173174, 2020
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