Élie Besserer-Offroy
Élie Besserer-Offroy
Principal Investigator, Inserm U1086 - Anticipe, Baclesse Comprehensive Cancer Center
Verified email at - Homepage
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Discovery and structure–activity relationship of a bioactive fragment of ELABELA that modulates vascular and cardiac functions
A Murza, X Sainsily, D Coquerel, J Côté, P Marx, É Besserer-Offroy, ...
Journal of medicinal chemistry 59 (7), 2962-2972, 2016
Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties
M Demeule, N Beaudet, A Régina, É Besserer-Offroy, A Murza, ...
The Journal of clinical investigation 124 (3), 1199-1213, 2014
Elucidation of the structure–activity relationships of apelin: influence of unnatural amino acids on binding, signaling, and plasma stability
A Murza, A Parent, E Besserer‐Offroy, H Tremblay, F Karadereye, ...
ChemMedChem 7 (2), 318-325, 2012
Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs
A Luginina, A Gusach, E Marin, A Mishin, R Brouillette, P Popov, ...
Science advances 5 (10), eaax2518, 2019
The signaling signature of the neurotensin type 1 receptor with endogenous ligands
É Besserer-Offroy, RL Brouillette, S Lavenus, U Froehlich, A Brumwell, ...
European journal of pharmacology 805, 1-13, 2017
Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors
A Gusach, A Luginina, E Marin, RL Brouillette, É Besserer-Offroy, ...
Nature communications 10 (1), 5573, 2019
C-Terminal modifications of apelin-13 significantly change ligand binding, receptor signaling, and hypotensive action
A Murza, E Besserer-Offroy, J Cote, P Berube, JM Longpre, R Dumaine, ...
Journal of medicinal chemistry 58 (5), 2431-2440, 2015
Synthesis, in vitro and in vivo characterization of (L)-(trimethylsilyl) alanine containing neurotensin analogues
R Fanelli, É Besserer-Offroy, A René, J Côté, P Tétrault, ...
Journal of Medicinal Chemistry, 2015
Apelin-13 regulates vasopressin-induced aquaporin-2 expression and trafficking in kidney collecting duct cells
C Boulkeroua, H Ayari, T Khalfaoui, M Lafrance, É Besserer-Offroy, ...
Cell Physiol Biochem 53 (4), 687-700, 2019
Structure–activity relationship of novel macrocyclic biased apelin receptor agonists
A Murza, X Sainsily, J Côté, L Bruneau-Cossette, É Besserer-Offroy, ...
Organic & biomolecular chemistry 15 (2), 449-458, 2017
The hypotensive effect of activated apelin receptor is correlated with β-arrestin recruitment
É Besserer-Offroy, P Bérubé, J Côté, A Murza, JM Longpré, R Dumaine, ...
Pharmacological research 131, 7-16, 2018
Structural optimization and characterization of potent analgesic macrocyclic analogues of neurotensin (8–13)
M Sousbie, M Vivancos, RL Brouillette, É Besserer-Offroy, JM Longpre, ...
Journal of Medicinal Chemistry 61 (16), 7103-7115, 2018
Design, synthesis, and biological evaluation of CXCR4 ligands
CE Mona, É Besserer-Offroy, J Cabana, R Leduc, P Lavigne, N Heveker, ...
Organic & Biomolecular Chemistry 14 (43), 10298-10311, 2016
Structure-based virtual screening of ultra-large library yields potent antagonists for a lipid GPCR
AA Sadybekov, RL Brouillette, E Marin, AV Sadybekov, A Luginina, ...
Biomolecules 10 (12), 1634, 2020
Use of molecular modeling to design selective NTS2 neurotensin analogues
R Fanelli, N Floquet, E Besserer-Offroy, B Delort, M Vivancos, JM Longpre, ...
Journal of Medicinal Chemistry 60 (8), 3303-3313, 2017
Stereoselective Synthesis of β‐(5‐Arylthiazolyl) α‐Amino Acids and Use in Neurotensin Analogues
D Hapău, E Rémond, R Fanelli, M Vivancos, A René, J Côté, ...
European Journal of Organic Chemistry 2016 (5), 1017-1024, 2016
Structural insights on ligand recognition at the human leukotriene B4 receptor 1
N Michaelian, A Sadybekov, É Besserer-Offroy, GW Han, ...
Nature communications 12 (1), 2971, 2021
In search of the optimal macrocyclization site for neurotensin
M Sousbie, E Besserer-Offroy, RL Brouillette, JM Longpré, R Leduc, ...
ACS Medicinal Chemistry Letters 9 (3), 227-232, 2018
Cell-penetrating pepducins targeting the neurotensin receptor type 1 relieve pain
RL Brouillette, É Besserer-Offroy, CE Mona, M Chartier, S Lavenus, ...
Pharmacological research 155, 104750, 2020
Angiotensin II cyclic analogs as tools to investigate AT1R biased signaling mechanisms
D St-Pierre, J Cabana, BJ Holleran, É Besserer-Offroy, E Escher, ...
Biochemical Pharmacology 154, 104-117, 2018
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