| Synthesis of the death-cap mushroom toxin α-amanitin K Matinkhoo, A Pryyma, M Todorovic, BO Patrick, DM Perrin Journal of the American Chemical Society 140 (21), 6513-6517, 2018 | 97 | 2018 |
| Synthesis of a cytotoxic amanitin for biorthogonal conjugation L Zhao, JP May, A Blanc, DJ Dietrich, A Loonchanta, K Matinkhoo, ... ChemBioChem 16 (10), 1420-1425, 2015 | 40 | 2015 |
| One-step 18F-labeling and preclinical evaluation of prostate-specific membrane antigen trifluoroborate probes for cancer imaging HT Kuo, ML Lepage, KS Lin, J Pan, Z Zhang, Z Liu, A Pryyma, C Zhang, ... Journal of Nuclear Medicine 60 (8), 1160-1166, 2019 | 23 | 2019 |
| Synthesis and Activation of Bench-Stable 3a-Fluoropyrroloindolines as Latent Electrophiles for the Synthesis of C-2-Thiol-Substituted Tryptophans and C-3a-Substituted … A Pryyma, YJ Bu, Y Wai, BO Patrick, DM Perrin Organic letters 21 (20), 8234-8238, 2019 | 15 | 2019 |
| Meeting key synthetic challenges in amanitin synthesis with a new cytotoxic analog: 5′-hydroxy-6′-deoxy-amanitin A Pryyma, K Matinkhoo, AAWL Wong, DM Perrin Chemical Science 11 (43), 11927-11935, 2020 | 10 | 2020 |
| Rapid, high-yielding solid-phase synthesis of cathepsin-B cleavable linkers for targeted cancer therapeutics A Pryyma, S Gunasekera, J Lewin, DM Perrin Bioconjugate Chemistry 31 (12), 2685-2690, 2020 | 9 | 2020 |
| Synthesis and preliminary evaluation of octreotate conjugates of bioactive synthetic amatoxins for targeting somatostatin receptor (sstr2) expressing cells A Pryyma, K Matinkhoo, YJ Bu, H Merkens, Z Zhang, F Bénard, DM Perrin RSC Chemical Biology 3 (1), 69-78, 2022 | 7 | 2022 |
| Scaling Amatoxin Synthesis with an Improved Route to (2S,3R,4R)-Dihydroxyisoleucine Exemplified by a Toxic, Clickable α-Amanitin Analogue CM Hambira, K Matinkhoo, A Pryyma, BO Patrick, DM Perrin The Journal of Organic Chemistry 86 (7), 5362-5370, 2021 | 7 | 2021 |
| Rationally designed amanitins achieve enhanced cytotoxicity M Todorovic, P Rivollier, AAWL Wong, Z Wang, A Pryyma, TT Nguyen, ... Journal of Medicinal Chemistry 65 (15), 10357-10376, 2022 | 6 | 2022 |
| Synthesis and evaluation of “Ama-Flash”, a photocaged amatoxin prodrug for light-activated RNA Pol II inhibition and cell death K Matinkhoo, A Pryyma, AAWL Wong, DM Perrin Chemical Communications 57 (75), 9558-9561, 2021 | 3 | 2021 |
| Diphenylphoshinylhydroxylamine (DPPH) Affords Late‐Stage S‐Imination To Access Free‐NH Sulfilimines and Sulfoximines S Gunasekera, A Pryyma, J Jung, R Greenwood, BO Patrick, D Perrin Angewandte Chemie International Edition, e202314906, 2024 | | 2024 |
| Methodologies for synthesis of transcription inhibiting peptides, amatoxins, and their bioconjugates for targeted cancer therapy A Pryyma University of British Columbia, 2022 | | 2022 |
| Rapid, High-Yielding Solid-phase Synthesis of Cathepsin-B Cleavable Linkers for Targeted Cancer Therapeutics Alla Pryyma, Shanal Gunasekera, Joshua Lewin, David Perrin First Canadian Peptide and Protein Community Virtual Symposium, 2021 | | 2021 |
| Chemical Biology A Pryyma, K Matinkhoo, YJ Bu, H Merkens, Z Zhang, F Bénardb, ... | | 2021 |
Brian O. PatrickManager, Structural Chemistry, University of British ColumbiaVerified email at chem.ubc.ca
