| Fueling open‐source drug discovery: 177 small‐molecule leads against tuberculosis L Ballell, RH Bates, RJ Young, D Alvarez‐Gomez, E Alvarez‐Ruiz, ... ChemMedChem 8 (2), 313-321, 2013 | 357 | 2013 |
| New small-molecule synthetic antimycobacterials L Ballell, RA Field, K Duncan, RJ Young Antimicrobial agents and chemotherapy 49 (6), 2153-2163, 2005 | 249 | 2005 |
| Identification of novel imidazo [1, 2-a] pyridine inhibitors targeting M. tuberculosis QcrB KA Abrahams, JAG Cox, VL Spivey, NJ Loman, MJ Pallen, ... PloS one 7 (12), e52951, 2012 | 200 | 2012 |
| Tetrahydropyrazolo [1, 5-a] pyrimidine-3-carboxamide and N-benzyl-6′, 7′-dihydrospiro [piperidine-4, 4′-thieno [3, 2-c] pyran] analogues with bactericidal efficacy against … MJ Remuiñán, E Pérez-Herrán, J Rullás, C Alemparte, M Martínez-Hoyos, ... PloS one 8 (4), e60933, 2013 | 152 | 2013 |
| New thiopyrazolo [3, 4-d] pyrimidine derivatives as anti-mycobacterial agents L Ballell, RA Field, GAC Chung, RJ Young Bioorganic & medicinal chemistry letters 17 (6), 1736-1740, 2007 | 152 | 2007 |
| β-Lactams against tuberculosis—new trick for an old dog? AH Diacon, L van der Merwe, M Barnard, F von Groote-Bidlingmaier, ... New England Journal of Medicine 375 (4), 393-394, 2016 | 150 | 2016 |
| Encoded library technology as a source of hits for the discovery and lead optimization of a potent and selective class of bactericidal direct inhibitors of Mycobacterium … L Encinas, H O’Keefe, M Neu, MJ Remuiñán, AM Patel, A Guardia, ... Journal of Medicinal Chemistry 57 (4), 1276-1288, 2014 | 121 | 2014 |
| Rapid cytolysis of Mycobacterium tuberculosis by faropenem, an orally bioavailable β-lactam antibiotic N Dhar, V Dubée, L Ballell, G Cuinet, JE Hugonnet, F Signorino-Gelo, ... Antimicrobial agents and chemotherapy 59 (2), 1308-1319, 2015 | 113 | 2015 |
| Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection G Poce, RH Bates, S Alfonso, M Cocozza, GC Porretta, L Ballell, J Rullas, ... PloS one 8 (2), e56980, 2013 | 113 | 2013 |
| A new piperidinol derivative targeting mycolic acid transport in Mycobacterium abscessus C Dupont, A Viljoen, F Dubar, M Blaise, A Bernut, A Pawlik, C Bouchier, ... Molecular microbiology 101 (3), 515-529, 2016 | 108 | 2016 |
| Identification of KasA as the cellular target of an anti-tubercular scaffold KA Abrahams, C Chung, S Ghidelli-Disse, J Rullas, MJ Rebollo-López, ... Nature communications 7 (1), 12581, 2016 | 91 | 2016 |
| Repurposing clinically approved cephalosporins for tuberculosis therapy S Ramón-García, R González del Río, AS Villarejo, GD Sweet, ... Scientific reports 6 (1), 34293, 2016 | 88 | 2016 |
| Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis Y Park, A Pacitto, T Bayliss, LAT Cleghorn, Z Wang, T Hartman, K Arora, ... ACS infectious diseases 3 (1), 18-33, 2017 | 85 | 2017 |
| A new chemical probe for proteomics of carbohydrate-binding proteins L Ballell, KJ Alink, M Slijper, C Versluis, RMJ Liskamp, RJ Pieters ChemBioChem 6 (2), 291-295, 2004 | 82 | 2004 |
| Design, synthesis, and evaluation of new thiadiazole-based direct inhibitors of enoyl acyl carrier protein reductase (InhA) for the treatment of tuberculosis R Sink, I Sosic, M Zivec, R Fernandez-Menendez, S Turk, S Pajk, ... Journal of medicinal chemistry 58 (2), 613-624, 2015 | 77 | 2015 |
| Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening CA Machutta, CS Kollmann, KE Lind, X Bai, PF Chan, J Huang, L Ballell, ... Nature communications 8 (1), 16081, 2017 | 72 | 2017 |
| THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria JAG Cox, KA Abrahams, C Alemparte, S Ghidelli-Disse, J Rullas, ... Nature microbiology 1 (2), 1-10, 2016 | 69 | 2016 |
| Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor M Martínez-Hoyos, E Perez-Herran, G Gulten, L Encinas, ... EBioMedicine 8, 291-301, 2016 | 66 | 2016 |
| Whole Cell Target Engagement Identifies Novel Inhibitors of Mycobacterium tuberculosis Decaprenylphosphoryl-β-d-ribose Oxidase SM Batt, M Cacho Izquierdo, J Castro Pichel, CJ Stubbs, ... ACS Infectious Diseases 1 (12), 615-626, 2015 | 64 | 2015 |
| Testing tuberculosis drug efficacy in a zebrafish high-throughput translational medicine screen A Ordas, RJ Raterink, F Cunningham, HJ Jansen, MI Wiweger, ... Antimicrobial agents and chemotherapy 59 (2), 753-762, 2015 | 64 | 2015 |
Robert J YoungBlue Burgundy ConsultingVerified email at blue-burgundy.co.uk
