La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs RM Lahr, BD Fonseca, GE Ciotti, HA Al-Ashtal, JJ Jia, MR Niklaus, ... Elife 6, e24146, 2017 | 216 | 2017 |
The RNA-binding protein LARP1 is a post-transcriptional regulator of survival and tumorigenesis in ovarian cancer TG Hopkins, M Mura, HA Al-Ashtal, RM Lahr, N Abd-Latip, K Sweeney, ... Nucleic acids research 44 (3), 1227-1246, 2016 | 169 | 2016 |
mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1 JJ Jia, RM Lahr, MT Solgaard, BJ Moraes, R Pointet, AD Yang, G Celucci, ... Nucleic acids research 49 (6), 3461-3489, 2021 | 87 | 2021 |
The La-related protein 1-specific domain repurposes HEAT-like repeats to directly bind a 5′ TOP sequence RM Lahr, SM Mack, A Héroux, SP Blagden, C Bousquet-Antonelli, ... Nucleic acids research 43 (16), 8077-8088, 2015 | 86 | 2015 |
LARP1 on TOP of ribosome production BD Fonseca, RM Lahr, CK Damgaard, T Alain, AJ Berman Wiley Interdisciplinary Reviews: RNA 9 (5), e1480, 2018 | 83 | 2018 |
Serratia marcescens quinoprotein glucose dehydrogenase activity mediates medium acidification and inhibition of prodigiosin production by glucose JE Fender, CM Bender, NA Stella, RM Lahr, EJ Kalivoda, RMQ Shanks Applied and environmental microbiology 78 (17), 6225-6235, 2012 | 62 | 2012 |
A Serratia marcescens PigP homolog controls prodigiosin biosynthesis, swarming motility and hemolysis and is regulated by cAMP-CRP and HexS RMQ Shanks, RM Lahr, NA Stella, KE Arena, KM Brothers, DH Kwak, ... PloS one 8 (3), e57634, 2013 | 59 | 2013 |
Serratia marcescens cyclic AMP receptor protein controls transcription of EepR, a novel regulator of antimicrobial secondary metabolites NA Stella, RM Lahr, KM Brothers, EJ Kalivoda, KM Hunt, DH Kwak, X Liu, ... Journal of Bacteriology 197 (15), 2468-2478, 2015 | 45 | 2015 |
Serratamolide is a Hemolytic Factor Produced by Serratia marcescens RMQ Shanks, NA Stella, RM Lahr, S Wang, TI Veverka, RP Kowalski, ... PLoS One 7 (5), e36398, 2012 | 45 | 2012 |
Capturing the mechanism underlying TOP mRNA binding to LARP1 KC Cassidy, RM Lahr, JC Kaminsky, S Mack, BD Fonseca, SR Das, ... Structure 27 (12), 1771-1781. e5, 2019 | 35 | 2019 |
Reovirus nonstructural protein σNS acts as an RNA stability factor promoting viral genome replication PF Zamora, L Hu, JJ Knowlton, RM Lahr, RA Moreno, AJ Berman, ... Journal of virology 92 (15), 10.1128/jvi. 00563-18, 2018 | 28 | 2018 |
Recurrent enterococcal endophthalmitis seeded by an intraocular lens biofilm KV Miller, KM Eisley, RMQ Shanks, RM Lahr, KL Lathrop, RP Kowalski, ... Journal of Cataract & Refractive Surgery 37 (7), 1355-1359, 2011 | 28 | 2011 |
A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis ET Martin, P Blatt, E Nguyen, R Lahr, S Selvam, HAM Yoon, T Pocchiari, ... Developmental cell 57 (7), 883-900. e10, 2022 | 22 | 2022 |
Suppressor analysis of eepR mutant defects reveals coordinate regulation of secondary metabolites and serralysin biosynthesis by EepR and HexS RMQ Shanks, NA Stella, RM Lahr, MA Aston, KM Brothers, JD Callaghan, ... Microbiology 163 (2), 280-288, 2017 | 18 | 2017 |
The LysR transcription factor, HexS, is required for glucose inhibition of prodigiosin production by Serratia marcescens NA Stella, JE Fender, RM Lahr, EJ Kalivoda, RMQ Shanks Advances in microbiology 2 (4), 2012 | 18 | 2012 |
LARP1 is a major phosphorylation substrate of mTORC1 BD Fonseca, JJ Jia, AK Hollensen, R Pointet, HD Hoang, MR Niklaus, ... BioRxiv, 491274, 2018 | 15 | 2018 |
Elucidating the molecular mechanism of LARP1 in post-transcriptional regulation of TOP transcripts R Lahr University of Pittsburgh, 2019 | 1 | 2019 |
Small molecules as larp1 ligands JD Durrant, AJ Berman, KC Cassidy, RM Lahr US Patent App. 18/265,740, 2024 | | 2024 |
Capturing the Mechanism Underlying Top-Binding to the LARP1 DM15 Region KC Cassidy, RM Lahr, JC Kaminsky, AJ Berman, JD Durrant Biophysical Journal 116 (3), 434a, 2019 | | 2019 |
LARP1: gatekeeper of ribosome production BD Fonseca, R Lahr, AJ Berman, CK Damgaard, T Alain FEBS Journal 284 (Supplement 1), 46-47, 2018 | | 2018 |