Steven r Laplante
Steven r Laplante
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An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus
D Lamarre, PC Anderson, M Bailey, P Beaulieu, G Bolger, P Bonneau, ...
Nature 426 (6963), 186-189, 2003
The challenge of atropisomerism in drug discovery
J Clayden, WJ Moran, PJ Edwards, SR LaPlante
Angewandte Chemie International Edition 48 (35), 6398-6401, 2009
Assessing atropisomer axial chirality in drug discovery and development
SR LaPlante, LD Fader, KR Fandrick, DR Fandrick, O Hucke, R Kemper, ...
Journal of medicinal chemistry 54 (20), 7005-7022, 2011
Revealing atropisomer axial chirality in drug discovery
SR LaPlante, PJ Edwards, LD Fader, A Jakalian, O Hucke
ChemMedChem 6 (3), 505-513, 2011
Peptide-based inhibitors of the hepatitis C virus serine protease
M Llinas-Brunet, M Bailey, G Fazal, S Goulet, T Halmos, S Laplante, ...
Bioorganic & Medicinal Chemistry Letters 8 (13), 1713-1718, 1998
Macrocyclic inhibitors of the NS3 protease as potential therapeutic agents of hepatitis C virus infection
YS Tsantrizos, G Bolger, P Bonneau, DR Cameron, N Goudreau, G Kukolj, ...
Angewandte Chemie 115 (12), 1394-1398, 2003
Discovery of BI 224436, a noncatalytic site integrase inhibitor (NCINI) of HIV-1
LD Fader, E Malenfant, M Parisien, R Carson, F Bilodeau, S Landry, ...
ACS medicinal chemistry letters 5 (4), 422-427, 2014
Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery and preliminary SAR of benzimidazole derivatives
PL Beaulieu, M Bs, Y Bousquet, G Fazal, J Gauthier, J Gillard, S Goulet, ...
Bioorganic & medicinal chemistry letters 14 (1), 119-124, 2004
Atropisomerie als Herausforderung in der Medikamentenentwicklung
J Clayden, WJ Moran, PJ Edwards, SR LaPlante
Angewandte Chemie 121 (35), 6516-6520, 2009
13C-NMR relaxation in three DNA oligonucleotide duplexes: model-free analysis of internal and overall motion
PN Borer, SR LaPlante, A Kumar, N Zanatta, A Martin, A Hakkinen, ...
Biochemistry 33 (9), 2441-2450, 1994
Specific inhibitors of HCV polymerase identified using an NS5B with lower affinity for template/primer substrate
G McKercher, PL Beaulieu, D Lamarre, S LaPlante, S Lefebvre, C Pellerin, ...
Nucleic acids research 32 (2), 422-431, 2004
Compound aggregation in drug discovery: implementing a practical NMR assay for medicinal chemists
SR LaPlante, R Carson, J Gillard, N Aubry, R Coulombe, S Bordeleau, ...
Journal of medicinal chemistry 56 (12), 5142-5150, 2013
Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: from benzimidazole to indole scaffolds
PL Beaulieu, J Gillard, D Bykowski, C Brochu, N Dansereau, JS Duceppe, ...
Bioorganic & medicinal chemistry letters 16 (19), 4987-4993, 2006
Solution structure of substrate-based ligands when bound to hepatitis C virus NS3 protease domain
SR LaPlante, DR Cameron, N Aubry, S Lefebvre, G Kukolj, R Maurice, ...
Journal of Biological Chemistry 274 (26), 18618-18624, 1999
Preclinical profile of BI 224436, a novel HIV-1 non-catalytic-site integrase inhibitor
C Fenwick, M Amad, MD Bailey, R Bethell, M Bs, P Bonneau, ...
Antimicrobial agents and chemotherapy 58 (6), 3233-3244, 2014
NMR line-broadening and transferred NOESY as a medicinal chemistry tool for studying inhibitors of the hepatitis C virus NS3 protease domain
SR LaPlante, N Aubry, PR Bonneau, G Kukolj, D Lamarre, S Lefebvre, ...
Bioorganic & medicinal chemistry letters 10 (20), 2271-2274, 2000
Binding mode determination of benzimidazole inhibitors of the hepatitis C virus RNA polymerase by a structure and dynamics strategy
SR LaPlante, A Jakalian, N Aubry, Y Bousquet, JM Ferland, J Gillard, ...
Angewandte Chemie 116 (33), 4406-4411, 2004
Characterization of the human cytomegalovirus protease as an induced-fit serine protease and the implications to the design of mechanism-based inhibitors
SR LaPlante, PR Bonneau, N Aubry, DR Cameron, R Dziel, ...
Journal of the American Chemical Society 121 (13), 2974-2986, 1999
. alpha.-Cobratoxin: proton NMR assignment and solution structure
R Le Goas, SR LaPlante, A Mikou, MA Delsuc, E Guittet, M Robin, ...
Biochemistry 31 (20), 4867-4875, 1992
Scaffold hopping in the rational design of novel HIV-1 non-nucleoside reverse transcriptase inhibitors
JA O’Meara, A Jakalian, S LaPlante, PR Bonneau, R Coulombe, ...
Bioorganic & medicinal chemistry letters 17 (12), 3362-3366, 2007
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