Mario José Abdalla Saad
Mario José Abdalla Saad
Professor Titular da Faculdade de Ciências Médicas - FCM, UNICAMP
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Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus
CT De Souza, EP Araujo, S Bordin, R Ashimine, RL Zollner, AC Boschero, ...
Endocrinology 146 (10), 4192-4199, 2005
Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance
DML Tsukumo, MA Carvalho-Filho, JBC Carvalheira, PO Prada, ...
Diabetes 56 (8), 1986-1998, 2007
Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity
M Milanski, G Degasperi, A Coope, J Morari, R Denis, DE Cintra, ...
Journal of Neuroscience 29 (2), 359-370, 2009
Cross-talk between the insulin and angiotensin signaling systems
LA Velloso, F Folli, XJ Sun, MF White, MJ Saad, CR Kahn
Proceedings of the National Academy of Sciences 93 (22), 12490-12495, 1996
High-fat diet induces apoptosis of hypothalamic neurons
JC Moraes, A Coope, J Morari, DE Cintra, EA Roman, JR Pauli, ...
PloS one 4 (4), e5045, 2009
Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats.
MJ Saad, F Folli, JA Kahn, CR Kahn
The Journal of clinical investigation 92 (4), 2065-2072, 1993
Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance.
MJ Saad, E Araki, M Miralpeix, PL Rothenberg, MF White, CR Kahn
The Journal of clinical investigation 90 (5), 1839-1849, 1992
IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKβ and ER stress inhibition
ER Ropelle, MB Flores, DE Cintra, GZ Rocha, JR Pauli, J Morari, ...
PLoS Biol 8 (8), e1000465, 2010
Unsaturated fatty acids revert diet-induced hypothalamic inflammation in obesity
DE Cintra, ER Ropelle, JC Moraes, JR Pauli, J Morari, CT de Souza, ...
PloS one 7 (1), e30571, 2012
S-nitrosation of the insulin receptor, insulin receptor substrate 1, and protein kinase B/Akt: a novel mechanism of insulin resistance
MA Carvalho-Filho, M Ueno, SM Hirabara, AB Seabra, JBC Carvalheira, ...
Diabetes 54 (4), 959-967, 2005
Linking gut microbiota and inflammation to obesity and insulin resistance
MJA Saad, A Santos, PO Prada
Physiology, 2016
Gut microbiota is a key modulator of insulin resistance in TLR 2 knockout mice
AM Caricilli, PK Picardi, LL de Abreu, M Ueno, PO Prada, ER Ropelle, ...
PLoS Biol 9 (12), e1001212, 2011
Metformin amplifies chemotherapy-induced AMPK activation and antitumoral growth
GZ Rocha, MM Dias, ER Ropelle, F Osório-Costa, FA Rossato, ...
Clinical Cancer Research 17 (12), 3993-4005, 2011
Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat.
F Folli, MJ Saad, JM Backer, CR Kahn
Journal of Biological Chemistry 267 (31), 22171-22177, 1992
Modulation of gut microbiota by antibiotics improves insulin signalling in high-fat fed mice
BM Carvalho, D Guadagnini, DML Tsukumo, AA Schenka, P Latuf-Filho, ...
Diabetologia 55 (10), 2823-2834, 2012
Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus.
F Folli, MJ Saad, JM Backer, CR Kahn
The Journal of clinical investigation 92 (4), 1787-1794, 1993
A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in high-protein diet–induced weight loss
ER Ropelle, JR Pauli, MFA Fernandes, SA Rocco, RM Marin, J Morari, ...
Diabetes 57 (3), 594-605, 2008
Western Diet Modulates Insulin Signaling, c-Jun N-Terminal Kinase Activity, and Insulin Receptor Substrate-1ser307 Phosphorylation in a Tissue-Specific Fashion
PO Prada, HG Zecchin, AL Gasparetti, MA Torsoni, M Ueno, AE Hirata, ...
Endocrinology 146 (3), 1576-1587, 2005
Crosstalk between insulin and angiotensin II signalling systems
F Folli, MJA Saad, L Velloso, H Hansen, O Carandente, EP Feener, ...
Experimental and clinical endocrinology & diabetes 107 (02), 133-139, 1999
Pinealectomy causes glucose intolerance and decreases adipose cell responsiveness to insulin in rats
FB Lima, UF Machado, I Bartol, PM Seraphim, DH Sumida, SMF Moraes, ...
American Journal of Physiology-Endocrinology and Metabolism, 1998
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