William Jacobs
William Jacobs
Professor of Microbiology and Immunology, Albert Einstein College of Medline
Verified email at - Homepage
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inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis
A Banerjee, E Dubnau, A Quemard, V Balasubramanian, KS Um, ...
Science 263 (5144), 227-230, 1994
Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase
JD McKinney, KH Zu Bentrup, EJ Muñoz-Elías, A Miczak, B Chen, ...
Nature 406 (6797), 735-738, 2000
An outbreak of tuberculosis with accelerated progression among persons infected with the Human Immunodeficiency Virus: an analysis using restriction-fragment—length polymorphisms
CL Daley, PM Small, GF Schecter, GK Schoolnik, RA McAdam, ...
New England journal of medicine 326 (4), 231-235, 1992
The primary mechanism of attenuation of bacillus Calmette–Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue
T Hsu, SM Hingley-Wilson, B Chen, M Chen, AZ Dai, PM Morin, CB Marks, ...
Proceedings of the National Academy of Sciences 100 (21), 12420-12425, 2003
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis
DA Rozwarski, GA Grant, DHR Barton, WR Jacobs, JC Sacchettini
Science 279 (5347), 98-102, 1998
Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice
JS Cox, B Chen, M McNeil, WR Jacobs
Nature 402 (6757), 79-83, 1999
Mechanisms of drug resistance in Mycobacterium tuberculosis
Y Zhang, WR Jacobs Jr, C Vilchèze
Tuberculosis and the tubercle bacillus, 115-140, 2005
A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis
MS Glickman, JS Cox, WR Jacobs Jr
Molecular cell 5 (4), 717-727, 2000
Origins of highly mosaic mycobacteriophage genomes
ML Pedulla, ME Ford, JM Houtz, T Karthikeyan, C Wadsworth, JA Lewis, ...
Cell 113 (2), 171-182, 2003
Specialized transduction: an efficient method for generating marked and unmarked targeted gene disruptions in Mycobacterium tuberculosis, M. bovis BCG and M. smegmatis
S Bardarov, S Bardarov Jr, MS Pavelka Jr, V Sambandamurthy, M Larsen, ...
Microbiology 148 (10), 3007-3017, 2002
Cloning and nucleotide sequence of Mycobacterium tuberculosis gyrA and gyrB genes and detection of quinolone resistance mutations.
HE Takiff, L Salazar, C Guerrero, W Philipp, WM Huang, B Kreiswirth, ...
Antimicrobial agents and chemotherapy 38 (4), 773-780, 1994
The emb operon, a gene cluster of Mycobacterium tuberculosis involved in resistance to ethambutol
A Telenti, WJ Philipp, S Sreevatsan, C Bernasconi, KE Stockbauer, ...
Nature medicine 3 (5), 567-570, 1997
Rapid assessment of drug susceptibilities of Mycobacterium tuberculosis by means of luciferase reporter phages
WR Jacobs, RG Barletta, R Udani, J Chan, G Kalkut, G Sosne, T Kieser, ...
Science 260 (5109), 819-822, 1993
Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis
A Dessen, A Quemard, JS Blanchard, WR Jacobs, JC Sacchettini
Science 267 (5204), 1638-1641, 1995
Growth of Mycobacterium tuberculosis biofilms containing free mycolic acids and harbouring drug‐tolerant bacteria
AK Ojha, AD Baughn, D Sambandan, T Hsu, X Trivelli, Y Guerardel, ...
Molecular microbiology 69 (1), 164-174, 2008
Efficient allelic exchange and transposon mutagenesis in Mycobacterium tuberculosis
V Pelicic, M Jackson, JM Reyrat, WR Jacobs, B Gicquel, C Guilhot
Proceedings of the National Academy of Sciences 94 (20), 10955-10960, 1997
[25] Genetic systems for mycobacteria
WR Jacobs Jr, GV Kalpana, JD Cirillo, L Pascopella, SB Snapper, ...
Methods in enzymology 204, 537-555, 1991
Site-specific integration of mycobacteriophage L5: integration-proficient vectors for Mycobacterium smegmatis, Mycobacterium tuberculosis, and bacille Calmette-Guerin.
MH Lee, L Pascopella, WR Jacobs, GF Hatfull
Proceedings of the National Academy of Sciences 88 (8), 3111-3115, 1991
Microbial pathogenesis of Mycobacterium tuberculosis: dawn of a discipline
MS Glickman, WR Jacobs
Cell 104 (4), 477-485, 2001
Ethambutol resistance in Mycobacterium tuberculosis: critical role of embB mutations.
S Sreevatsan, KE Stockbauer, XI Pan, BN Kreiswirth, SL Moghazeh, ...
Antimicrobial agents and chemotherapy 41 (8), 1677-1681, 1997
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