| Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer KD Proffitt, B Madan, Z Ke, V Pendharkar, L Ding, MA Lee, RN Hannoush, ... Cancer research 73 (2), 502-507, 2013 | 393 | 2013 |
| Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts Z Kabiri, G Greicius, B Madan, S Biechele, Z Zhong, H Zaribafzadeh, ... Development 141 (11), 2206-2215, 2014 | 348 | 2014 |
| Wnt addiction of genetically defined cancers reversed by PORCN inhibition B Madan, Z Ke, N Harmston, SY Ho, AO Frois, J Alam, DA Jeyaraj, ... Oncogene 35 (17), 2197-2207, 2016 | 322 | 2016 |
| SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies S Hart, KC Goh, V Novotny-Diermayr, CY Hu, H Hentze, YC Tan, B Madan, ... Leukemia 25 (11), 1751-1759, 2011 | 208 | 2011 |
| Isoliquiritigenin inhibits IκB kinase activity and ROS generation to block TNF-α induced expression of cell adhesion molecules on human endothelial cells S Kumar, A Sharma, B Madan, V Singhal, B Ghosh Biochemical pharmacology 73 (10), 1602-1612, 2007 | 143 | 2007 |
| Targeting Wnts at the source—new mechanisms, new biomarkers, new drugs B Madan, DM Virshup Molecular cancer therapeutics 14 (5), 1087-1094, 2015 | 108 | 2015 |
| Pacritinib (SB1518), a JAK2/FLT3 inhibitor for the treatment of acute myeloid leukemia S Hart, KC Goh, V Novotny-Diermayr, YC Tan, B Madan, C Amalini, ... Blood cancer journal 1 (11), e44-e44, 2011 | 108 | 2011 |
| Impaired function of primitive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog MLL5 V Madan, B Madan, U Brykczynska, F Zilbermann, K Hogeveen, K Döhner, ... Blood, The Journal of the American Society of Hematology 113 (7), 1444-1454, 2009 | 108 | 2009 |
| USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds B Madan, MP Walker, R Young, L Quick, KA Orgel, M Ryan, P Gupta, ... Proceedings of the National Academy of Sciences 113 (21), E2945-E2954, 2016 | 96 | 2016 |
| Bone loss from Wnt inhibition mitigated by concurrent alendronate therapy B Madan, MJ McDonald, GE Foxa, CR Diegel, BO Williams, DM Virshup Bone research 6 (1), 17, 2018 | 93 | 2018 |
| 2′-Hydroxychalcone inhibits nuclear factor-κB and blocks tumor necrosis factor-α-and lipopolysaccharide-induced adhesion of neutrophils to human umbilical vein endothelial cells B Madan, S Batra, B Ghosh Molecular Pharmacology 58 (3), 526-534, 2000 | 89 | 2000 |
| Polarized helper T cells in tubercular pleural effusion: phenotypic identity and selective recruitment DK Mitra, SK Sharma, AK Dinda, MS Bindra, B Madan, B Ghosh European journal of immunology 35 (8), 2367-2375, 2005 | 83 | 2005 |
| VS-5584, a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer S Hart, V Novotny-Diermayr, KC Goh, M Williams, YC Tan, LC Ong, ... Molecular cancer therapeutics 12 (2), 151-161, 2013 | 76 | 2013 |
| Xanthones as inhibitors of microsomal lipid peroxidation and TNF-α induced ICAM-1 expression on human umbilical vein endothelial cells (HUVECs) B Madan, I Singh, A Kumar, AK Prasad, HG Raj, VS Parmar, B Ghosh Bioorganic & medicinal chemistry 10 (11), 3431-3436, 2002 | 72 | 2002 |
| The Pluripotency-Associated Gene Dppa4 Is Dispensable for Embryonic Stem Cell Identity and Germ Cell Development but Essential for Embryogenesis B Madan, V Madan, O Weber, P Tropel, C Blum, E Kieffer, S Viville, ... Molecular and cellular biology 29 (11), 3186-3203, 2009 | 69 | 2009 |
| Wnts and the hallmarks of cancer Z Zhong, J Yu, DM Virshup, B Madan Cancer and Metastasis Reviews 39 (3), 625-645, 2020 | 66 | 2020 |
| Diferuloylmethane inhibits neutrophil infiltration and improves survival of mice in high-dose endotoxin shock B Madan, B Ghosh Shock 19 (1), 91-96, 2003 | 65 | 2003 |
| PORCN inhibition synergizes with PI3K/mTOR inhibition in Wnt-addicted cancers Z Zhong, S Sepramaniam, XH Chew, K Wood, MA Lee, B Madan, ... Oncogene 38 (40), 6662-6677, 2019 | 63 | 2019 |
| TP53 intron 1 hotspot rearrangements are specific to sporadic osteosarcoma and can cause Li-Fraumeni syndrome S Ribi, D Baumhoer, K Lee, ASM Teo, B Madan, K Zhang, WK Kohlmann, ... Oncotarget 6 (10), 7727, 2015 | 60 | 2015 |
| Temporal dynamics of Wnt-dependent transcriptome reveal an oncogenic Wnt/MYC/ribosome axis B Madan, N Harmston, G Nallan, A Montoya, P Faull, E Petretto, ... The Journal of clinical investigation 128 (12), 5620-5633, 2019 | 58 | 2019 |
David M. VirshupDuke-NUS Medical School SingaporeVerified email at duke-nus.edu.sg
