Dr. Björn Over
Dr. Björn Over
Rhein-Chemotechnik GmbH
Verified email at rhein-chemotechnik.com - Homepage
Title
Cited by
Cited by
Year
Oral druggable space beyond the rule of 5: insights from drugs and clinical candidates
BC Doak, B Over, F Giordanetto, J Kihlberg
Chemistry & biology 21 (9), 1115-1142, 2014
2292014
Natural-product-derived fragments for fragment-based ligand discovery
B Over, S Wetzel, C Grütter, Y Nakai, S Renner, D Rauh, H Waldmann
Nature chemistry 5 (1), 21-28, 2013
2032013
Cell permeability beyond the rule of 5
P Matsson, BC Doak, B Over, J Kihlberg
Advanced drug delivery reviews 101, 42-61, 2016
932016
Structural and conformational determinants of macrocycle cell permeability
B Over, P Matsson, C Tyrchan, P Artursson, BC Doak, MA Foley, ...
Nature chemical biology 12 (12), 1065, 2016
722016
Impact of stereospecific intramolecular hydrogen bonding on cell permeability and physicochemical properties
B Over, P McCarren, P Artursson, M Foley, F Giordanetto, G Grönberg, ...
Journal of medicinal chemistry 57 (6), 2746-2754, 2014
612014
Identification and further development of thiazolidinones spiro-fused to indolin-2-ones as potent and selective inhibitors of Mycobacterium tuberculosis protein tyrosine …
VV Vintonyak, K Warburg, B Over, K Hübel, D Rauh, H Waldmann
Tetrahedron 67 (35), 6713-6729, 2011
472011
Impact of dynamically exposed polarity on permeability and solubility of chameleonic drugs beyond the rule of 5
M Rossi Sebastiano, BC Doak, M Backlund, V Poongavanam, B Over, ...
Journal of Medicinal Chemistry 61 (9), 4189-4202, 2018
432018
Fragment‐Based Lead Discovery: Screening and Optimizing Fragments for Thermolysin Inhibition
L Englert, K Silber, H Steuber, S Brass, B Over, HD Gerber, A Heine, ...
ChemMedChem 5 (6), 930-940, 2010
292010
Erratum: Structural and conformational determinants of macrocycle cell permeability.
B Over, P Matsson, C Tyrchan, P Artursson, BC Doak, MA Foley, ...
Nature chemical biology 13 (8), 922, 2017
2017
How to design cell permeable non-peptidic macrocycles
B Over, P Matsson, C Tyrchan, P Artursson, B Doak, M Foley, ...
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 251, 2016
2016
Macrocyclic drugs and clinical candidates-what are the limits of oral bioavailability?
B Doak, B Over, F Giordanetto, J Kihlberg
Abstract of Papers of the American Chemical Society 248, 2014
2014
Chemoinformatische Entwicklung von Naturstofffragmenten, sowie deren strukturbiologische und biochemische Evaluierung zur fragmentbasierten Inhibitorentwicklung
B Over
Universitätsbibliothek Dortmund, 2013
2013
Synthese von Thermolysininhibitoren unter Verwendung eines fragmentbasierten Ansatzes zur Wirkstoffentwicklung
B Over
2008
Full wwPDB X-ray Structure Validation Report i○
CC Lee, DJ Kim
Extent of oral druggable space beyond the rule of 5: Learnings from drugs and clinical candidates
BC Doak, B Over, F Giordanetto, J Kihlberg
Chemistry & Biology, 0
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Articles 1–15