Christopher M Overall

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Georgina S. ButlerResearch Associate, Center for Blood Research, University of British Columbia, Canada.Verified email at ubc.ca
Ulrich auf dem KellerTechnical University of DenmarkVerified email at dtu.dk
Antoine DufourAssociate Professsor, University of CalgaryVerified email at ucalgary.ca
Ulrich Eckhard (ORCID:0000-0001-58...Group Leader, Department of Structural and Molecular Biology, IBMB-CSIC (ROR:05t8khn72)Verified email at ibmb.csic.es
Pitter F. HuesgenUniversity of Freiburg, CIBSS - Centre for Integrative Biological Signalling StudiesVerified email at biologie.uni-freiburg.de
Philipp F. LangeCanada Research Chair & Associate Professor of Pathology, University of British ColumbiaVerified email at ubc.ca
Theo KleinNetherlands Forensics Institute NFIVerified email at nfi.nl
Oliver SchillingUniversity of FreiburgVerified email at mol-med.uni-freiburg.de
Jayachandran N KizhakkedathuUniversity of British ColumbiaVerified email at pathology.ubc.ca
Jeff WranaSenior Investigator, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto; Professor, Dept. of Mol. Gen., U. ofVerified email at lunenfeld.ca
U. Margaretha WallonAssist. Professor, Lankenau Institute for Medical ResearchVerified email at MLHS.org
Nikolaus FortelnyUniversity of SalzburgVerified email at plus.ac.at
Steve WithersProfessor of Chemistry and Biochemistry, University Of British ColumbiaVerified email at chem.ubc.ca
Paul PavlidisProfessor of Psychiatry, University of British ColumbiaVerified email at msl.ubc.ca
Richard TingWeill Cornell Medicine, Department of RadiologyVerified email at med.cornell.edu
Yves DeClerckProfessor of Pediatrics and Biochemistry and Molecular BiologyVerified email at usc.edu
Tuula SaloUniversidade Estadual de Campinas (Faculdade de Odontologia de Piracicaba)Verified email at unicamp.br
Christoph Becker-PaulyProfessor of Biochemistry, University of KielVerified email at biochem.uni-kiel.de
Duanqing PeiWestlake UniversityVerified email at westlake.edu.cn
Peter FriedlRadboud University NijmegenVerified email at radboudumc.nl

Christopher M Overall

University of British Columbia

Verified email at ubc.ca - Homepage

proteomics degradomics protease MMP SARS-CoV-2 3CLpro


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Strategies for MMP inhibition in cancer: innovations for the post-trial era CM Overall, C López-Otín Nature Reviews Cancer 2 (9), 657-672, 2002	1725	2002
Validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy CM Overall, O Kleifeld Nature Reviews Cancer 6 (3), 227-239, 2006	1444	2006
Human and mouse proteases: a comparative genomic approach XS Puente, LM Sánchez, CM Overall, C López-Otín Nature Reviews Genetics 4 (7), 544-558, 2003	1280	2003
Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion K Wolf, YI Wu, Y Liu, J Geiger, E Tam, C Overall, MS Stack, P Friedl Nature cell biology 9 (8), 893-904, 2007	1244	2007
Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3 GA McQuibban, JH Gong, EM Tam, CAG McCulloch, I Clark-Lewis, ... Science 289 (5482), 1202-1206, 2000	981	2000
Protease degradomics: a new challenge for proteomics C López-Otín, CM Overall Nature reviews Molecular cell biology 3 (7), 509-519, 2002	964	2002
Independent regulation of collagenase, 72-kDa progelatinase, and metalloendoproteinase inhibitor expression in human fibroblasts by transforming growth factor-β CM Overall, JL Wrana, J Sodek Journal of Biological Chemistry 264 (3), 1860-1869, 1989	849	1989
Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell-derived factor-1 GA McQuibban, GS Butler, JH Gong, L Bendall, C Power, I Clark-Lewis, ... Journal of Biological Chemistry 276 (47), 43503-43508, 2001	800	2001
Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors Y Lou, PC McDonald, A Oloumi, S Chia, C Ostlund, A Ahmadi, A Kyle, ... Cancer research 71 (9), 3364-3376, 2011	788	2011
Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo GA McQuibban, JH Gong, JP Wong, JL Wallace, I Clark-Lewis, ... Blood, The Journal of the American Society of Hematology 100 (4), 1160-1167, 2002	772	2002
Matrix metalloproteinases: what do they not do? New substrates and biological roles identified by murine models and proteomics D Rodríguez, CJ Morrison, CM Overall Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1803 (1), 39-54, 2010	721	2010
Molecular determinants of metalloproteinase substrate specificity: matrix metalloproteinase substrate binding domains, modules, and exosites CM Overall Molecular biotechnology 22, 51-86, 2002	669	2002
Transcriptional and post-transcriptional regulation of 72-kDa gelatinase/type IV collagenase by transforming growth factor-beta 1 in human fibroblasts. Comparisons with … CM Overall, JL Wrana, J Sodek Journal of Biological Chemistry 266 (21), 14064-14071, 1991	622	1991
Loss of collagenase-2 confers increased skin tumor susceptibility to male mice M Balbín, A Fueyo, AM Tester, AM Pendás, AS Pitiot, A Astudillo, ... Nature genetics 35 (3), 252-257, 2003	603	2003
Antisense RNA-induced reduction in murine TIMP levels confers oncogenicity on Swiss 3T3 cells R Khokha, P Waterhouse, S Yagel, PK Lala, CM Overall, G Norton, ... Science 243 (4893), 947-950, 1989	592	1989
Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products O Kleifeld, A Doucet, U auf dem Keller, A Prudova, O Schilling, ... Nature biotechnology 28 (3), 281-288, 2010	575	2010
Microbiota and crevicular fluid collagenase activity in the osseointegrated dental implant sulcus: a comparison of sites in edentulous and partially edentulous patients P Apse, RP Ellen, CM Overall, GA Zarb Journal of periodontal research 24 (2), 96-105, 1989	529	1989
Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites O Schilling, CM Overall Nature biotechnology 26 (6), 685-694, 2008	451	2008
Towards third generation matrix metalloproteinase inhibitors for cancer therapy CM Overall, O Kleifeld British journal of cancer 94 (7), 941-946, 2006	427	2006
Proteolytic host cell enzymes in gingival crevice fluid. VJ Uitto, CM Overall, C McCulloch Periodontology 2000 31 (1), 2003	424	2003

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