Ali Asadi
Ali Asadi
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Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells
A Rezania, JE Bruin, P Arora, A Rubin, I Batushansky, A Asadi, S O'dwyer, ...
Nature biotechnology 32 (11), 1121-1133, 2014
Maturation of human embryonic stem cell–derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice
A Rezania, JE Bruin, MJ Riedel, M Mojibian, A Asadi, J Xu, R Gauvin, ...
Diabetes 61 (8), 2016-2029, 2012
Hyperinsulinemia drives diet-induced obesity independently of brain insulin production
AE Mehran, NM Templeman, GS Brigidi, GE Lim, KY Chu, X Hu, ...
Cell metabolism 16 (6), 723-737, 2012
The pancreatic β cell is a key site for mediating the effects of leptin on glucose homeostasis
SD Covey, RD Wideman, C McDonald, S Unniappan, F Huynh, A Asadi, ...
Cell metabolism 4 (4), 291-302, 2006
Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo
Y Fujita, RD Wideman, M Speck, A Asadi, DS King, TD Webber, ...
American Journal of Physiology-Endocrinology and Metabolism 296 (3), E473-E479, 2009
Immunohistochemical characterisation of cells co-producing insulin and glucagon in the developing human pancreas
MJ Riedel, A Asadi, R Wang, Z Ao, GL Warnock, TJ Kieffer
Diabetologia 55, 372-381, 2012
Glucose-dependent insulinotropic polypeptide is expressed in pancreatic islet α-cells and promotes insulin secretion
Y Fujita, RD Wideman, A Asadi, GK Yang, R Baker, T Webber, T Zhang, ...
Gastroenterology 138 (5), 1966-1975. e1, 2010
Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells
JE Bruin, S Erener, J Vela, X Hu, JD Johnson, HT Kurata, FC Lynn, ...
Stem cell research 12 (1), 194-208, 2014
Duodenal-jejunal bypass protects GK rats from β-cell loss and aggravation of hyperglycemia and increases enteroendocrine cells coexpressing GIP and GLP-1
M Speck, YM Cho, A Asadi, F Rubino, TJ Kieffer
American Journal of Physiology-Endocrinology and Metabolism 300 (5), E923-E932, 2011
A GIP receptor agonist exhibits β-cell anti-apoptotic actions in rat models of diabetes resulting in improved β-cell function and glycemic control
SB Widenmaier, SJ Kim, GK Yang, T De Los Reyes, C Nian, A Asadi, ...
PloS one 5 (3), e9590, 2010
Treating diet-induced diabetes and obesity with human embryonic stem cell-derived pancreatic progenitor cells and antidiabetic drugs
JE Bruin, N Saber, N Braun, JK Fox, M Mojibian, A Asadi, C Drohan, ...
Stem cell reports 4 (4), 605-620, 2015
Accelerated maturation of human stem cell-derived pancreatic progenitor cells into insulin-secreting cells in immunodeficient rats relative to mice
JE Bruin, A Asadi, JK Fox, S Erener, A Rezania, TJ Kieffer
Stem cell reports 5 (6), 1081-1096, 2015
Differential processing of pro-glucose-dependent insulinotropic polypeptide in gut
Y Fujita, A Asadi, GK Yang, YN Kwok, TJ Kieffer
American Journal of Physiology-Gastrointestinal and Liver Physiology 298 (5 …, 2010
Musashi expression in β-cells coordinates insulin expression, apoptosis and proliferation in response to endoplasmic reticulum stress in diabetes
M Szabat, TB Kalynyak, GE Lim, KY Chu, YH Yang, A Asadi, BK Gage, ...
Cell death & disease 2 (11), e232-e232, 2011
Ontogeny of ghrelin, obestatin, preproghrelin, and prohormone convertases in rat pancreas and stomach
P Walia, A Asadi, TJ Kieffer, JD Johnson, JP Chanoine
Pediatric Research 65 (1), 39-44, 2009
Revisiting proinsulin processing: evidence that human β-cells process proinsulin with prohormone convertase (PC) 1/3 but not PC2
A Ramzy, A Asadi, TJ Kieffer
Diabetes 69 (7), 1451-1462, 2020
The role of ARX in human pancreatic endocrine specification
BK Gage, A Asadi, RK Baker, TD Webber, R Wang, M Itoh, M Hayashi, ...
PLoS One 10 (12), e0144100, 2015
Implanted islets in the anterior chamber of the eye are prone to autoimmune attack in a mouse model of diabetes
M Mojibian, B Harder, A Hurlburt, JE Bruin, A Asadi, TJ Kieffer
Diabetologia 56, 2213-2221, 2013
Dual role of interleukin‐1β in islet amyloid formation and its β‐cell toxicity: I mplications for type 2 diabetes and islet transplantation
YJ Park, GL Warnock, Z Ao, N Safikhan, M Meloche, A Asadi, TJ Kieffer, ...
Diabetes, Obesity and Metabolism 19 (5), 682-694, 2017
DsAAV8-mediated expression of glucagon-like peptide-1 in pancreatic beta-cells ameliorates streptozotocin-induced diabetes
MJ Riedel, DF Gaddy, A Asadi, PD Robbins, TJ Kieffer
Gene Therapy 17 (2), 171-180, 2010
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