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Yi-Chun Chen
Yi-Chun Chen
University of British Columbia
Verified email at bcchr.ca
Title
Cited by
Cited by
Year
Islet prohormone processing in health and disease
YC Chen, AJ Taylor, CB Verchere
Diabetes, Obesity and Metabolism 20, 64-76, 2018
782018
Glucocorticoid-induced suppression of β-cell proliferation is mediated by Mig6
ES Colvin, HY Ma, YC Chen, AM Hernandez, PT Fueger
Endocrinology 154 (3), 1039-1046, 2013
522013
Measurement of pro-islet amyloid polypeptide (1–48) in diabetes and islet transplants
JA Courtade, AM Klimek-Abercrombie, YC Chen, N Patel, PYT Lu, ...
The Journal of Clinical Endocrinology & Metabolism 102 (7), 2595-2603, 2017
422017
Islet macrophages shift to a reparative state following pancreatic beta-cell death and are a major source of islet insulin-like growth factor-1
D Nackiewicz, M Dan, M Speck, SZ Chow, YC Chen, JA Pospisilik, ...
Iscience 23 (1), 2020
392020
Upregulation of p21 activates the intrinsic apoptotic pathway in β-cells
AM Hernandez, ES Colvin, YC Chen, SL Geiss, LE Eller, PT Fueger
American Journal of Physiology-Endocrinology and Metabolism 304 (12), E1281 …, 2013
342013
Mitogen-inducible gene 6 triggers apoptosis and exacerbates ER stress-induced β-cell death
YC Chen, ES Colvin, BF Maier, RG Mirmira, PT Fueger
Molecular endocrinology 27 (1), 162-171, 2013
332013
The β cell in diabetes: integrating biomarkers with functional measures
SE Kahn, YC Chen, N Esser, AJ Taylor, DH van Raalte, S Zraika, ...
Endocrine reviews 42 (5), 528-583, 2021
302021
Altered β-cell prohormone processing and secretion in type 1 diabetes
T Rodriguez-Calvo, YC Chen, CB Verchere, L Haataja, P Arvan, P Leete, ...
Diabetes 70 (5), 1038-1050, 2021
252021
Mig6 haploinsufficiency protects mice against streptozotocin-induced diabetes
YC Chen, ES Colvin, KE Griffin, BF Maier, PT Fueger
Diabetologia 57, 2066-2075, 2014
202014
Depletion of PAK1 enhances ubiquitin-mediated survivin degradation in pancreatic β-cells
YC Chen, PT Fueger, Z Wang
Islets 5 (1), 22-28, 2013
162013
PAM haploinsufficiency does not accelerate the development of diet-and human IAPP-induced diabetes in mice
YC Chen, RE Mains, BA Eipper, BG Hoffman, TA Czyzyk, JE Pintar, ...
Diabetologia 63, 561-576, 2020
142020
Assessing replication and beta cell function in adenovirally-transduced isolated rodent islets
PT Fueger, AM Hernandez, YC Chen, ES Colvin
JoVE (Journal of Visualized Experiments), e4080, 2012
132012
SORLA mediates endocytic uptake of proIAPP and protects against islet amyloid deposition
AZL Shih, YC Chen, T Speckmann, E Søndergaard, A Schürmann, ...
Molecular Metabolism 65, 101585, 2022
62022
Elevated islet prohormone ratios as indicators of insulin dependency in auto-islet transplant recipients
YC Chen, AM Klimek-Abercrombie, KJ Potter, LP Pallo, G Soukhatcheva, ...
American Journal of Transplantation 22 (8), 1992-2005, 2022
32022
Beta‐cell prohormone convertase 1/3 plays a larger role in glucose homeostasis than beta‐cell prohormone convertase 2 in mice
AJ Taylor, YC Chen, CB Verchere
The FASEB Journal 34 (S1), 1-1, 2020
32020
Mitogen‐inducible gene 6 potentiates glucolipotoxicity‐induced pancreatic beta cell death
YC Chen, ES Colvin, PT Fueger
The FASEB Journal 27, lb743-lb743, 2013
22013
Glucolipotoxicity-induced Mig6 desensitizes EGFR signaling and promotes pancreatic beta cell death
YC Chen, AJ Lutkewitte, HD Basavarajappa, PT Fueger
bioRxiv, 2020.11. 24.380279, 2020
12020
Deletion of carboxypeptidase E in beta cells disrupts proinsulin processing and alters beta cell identity in mice
YC Chen, AJ Taylor, JM Fulcher, AC Swensen, XQ Dai, M Komba, ...
Diabetes 72 (9), 1277-1288, 2023
2023
Mig6 decreases hepatic EGFR activation and survival during saturated fatty acid-induced endoplasmic reticulum stress
AJ Lutkewitte, YC Chen, JL Hansen, PT Fueger
bioRxiv, 2020.11. 24.380527, 2020
2020
Correction to: PAM haploinsufficiency does not accelerate the development of diet and human IAPP-induced diabetes in mice
C Yi-Chun, RE Mains, BA Eipper, BG Hoffman, TA Czyzyk, JE Pintar, ...
Diabetologia 63 (5), 1090-1090, 2020
2020
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