Kun-Liang Guan
Kun-Liang Guan
Verified email at ucsd.edu - Homepage
Cited by
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Guidelines for the use and interpretation of assays for monitoring autophagy
DJ Klionsky, K Abdelmohsen, A Abe, MJ Abedin, H Abeliovich, ...
Autophagy 12 (1), 1-222, 2016
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
J Kim, M Kundu, B Viollet, KL Guan
Nature cell biology 13 (2), 132-141, 2011
TSC2 mediates cellular energy response to control cell growth and survival
K Inoki, T Zhu, KL Guan
Cell 115 (5), 577-590, 2003
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
K Inoki, Y Li, T Zhu, J Wu, KL Guan
Nature cell biology 4 (9), 648-657, 2002
Eukaryotic proteins expressed in Escherichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase
KL Guan, JE Dixon
Analytical biochemistry 192 (2), 262-267, 1991
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
B Zhao, X Wei, W Li, RS Udan, Q Yang, J Kim, J Xie, T Ikenoue, J Yu, L Li, ...
Genes & development 21 (21), 2747-2761, 2007
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases
W Xu, H Yang, Y Liu, Y Yang, P Wang, SH Kim, S Ito, C Yang, P Wang, ...
Cancer cell 19 (1), 17-30, 2011
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
K Inoki, Y Li, T Xu, KL Guan
Genes & development 17 (15), 1829-1834, 2003
TEAD mediates YAP-dependent gene induction and growth control
B Zhao, X Ye, J Yu, L Li, W Li, S Li, J Yu, JD Lin, CY Wang, ...
Genes & development 22 (14), 1962-1971, 2008
Regulation of cellular metabolism by protein lysine acetylation
S Zhao, W Xu, W Jiang, W Yu, Y Lin, T Zhang, J Yao, L Zhou, Y Zeng, H Li, ...
Science 327 (5968), 1000-1004, 2010
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth
K Inoki, H Ouyang, T Zhu, C Lindvall, Y Wang, X Zhang, Q Yang, ...
Cell 126 (5), 955-968, 2006
Regulation of TORC1 by Rag GTPases in nutrient response
E Kim, P Goraksha-Hicks, L Li, TP Neufeld, KL Guan
Nature cell biology 10 (8), 935-945, 2008
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1α
S Zhao, Y Lin, W Xu, W Jiang, Z Zha, P Wang, W Yu, Z Li, L Gong, Y Peng, ...
Science 324 (5924), 261-265, 2009
ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase
RC Russell, Y Tian, H Yuan, HW Park, YY Chang, J Kim, H Kim, ...
Nature cell biology 15 (7), 741-750, 2013
Dysregulation of the TSC-mTOR pathway in human disease
K Inoki, MN Corradetti, KL Guan
Nature genetics 37 (1), 19-24, 2005
Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling
FX Yu, B Zhao, N Panupinthu, JL Jewell, I Lian, LH Wang, J Zhao, H Yuan, ...
Cell 150 (4), 780-791, 2012
Hippo pathway in organ size control, tissue homeostasis, and cancer
FX Yu, B Zhao, KL Guan
Cell 163 (4), 811-828, 2015
Growth suppression by p18, a p16INK4/MTS1-and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.
KL Guan, CW Jenkins, Y Li, MA Nichols, X Wu, CL O'Keefe, AG Matera, ...
Genes & development 8 (24), 2939-2952, 1994
Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux
Q Wang, Y Zhang, C Yang, H Xiong, Y Lin, J Yao, H Li, L Xie, W Zhao, ...
Science 327 (5968), 1004-1007, 2010
The Hippo pathway: regulators and regulations
FX Yu, KL Guan
Genes & development 27 (4), 355-371, 2013
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