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Sean M. Armour, Ph.D.
Sean M. Armour, Ph.D.
Head of Discovery
Verified email at sparktx.com
Title
Cited by
Cited by
Year
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase
MA Selak, SM Armour, ED MacKenzie, H Boulahbel, DG Watson, ...
Cancer cell 7 (1), 77-85, 2005
22922005
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis
D Kim, MD Nguyen, MM Dobbin, A Fischer, F Sananbenesi, JT Rodgers, ...
The EMBO journal 26 (13), 3169-3179, 2007
12542007
Mitochondrial membrane potential regulates matrix configuration and cytochrome c release during apoptosis
E Gottlieb, SM Armour, MH Harris, CB Thompson
Cell Death & Differentiation 10 (6), 709-717, 2003
7902003
Evidence for a common mechanism of SIRT1 regulation by allosteric activators
BP Hubbard, AP Gomes, H Dai, J Li, AW Case, T Considine, TV Riera, ...
Science 339 (6124), 1216-1219, 2013
6572013
Discrete functions of nuclear receptor Rev-erbα couple metabolism to the clock
Y Zhang, B Fang, MJ Emmett, M Damle, Z Sun, D Feng, SM Armour, ...
Science 348 (6242), 1488-1492, 2015
3022015
Circadian enhancers coordinate multiple phases of rhythmic gene transcription in vivo
B Fang, LJ Everett, J Jager, E Briggs, SM Armour, D Feng, A Roy, ...
Cell 159 (5), 1140-1152, 2014
2182014
IgG-cleaving endopeptidase enables in vivo gene therapy in the presence of anti-AAV neutralizing antibodies
C Leborgne, E Barbon, JM Alexander, H Hanby, S Delignat, DM Cohen, ...
Nature medicine 26 (7), 1096-1101, 2020
2142020
Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy
SM Armour, JA Baur, SN Hsieh, A Land-Bracha, SM Thomas, DA Sinclair
Aging (Albany NY) 1 (6), 515, 2009
1792009
Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling
B Beirowski, J Gustin, SM Armour, H Yamamoto, A Viader, BJ North, ...
Proceedings of the National Academy of Sciences 108 (43), E952-E961, 2011
1692011
Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein
M Bernier, RK Paul, A Martin-Montalvo, M Scheibye-Knudsen, S Song, ...
Journal of Biological Chemistry 286 (22), 19270-19279, 2011
1512011
Mitochondrial respiratory control is lost during growth factor deprivation
E Gottlieb, SM Armour, CB Thompson
Proceedings of the National Academy of Sciences 99 (20), 12801-12806, 2002
992002
A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex
SM Armour, EJ Bennett, CR Braun, XY Zhang, SB McMahon, SP Gygi, ...
Molecular and cellular biology 33 (8), 1487-1502, 2013
712013
An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides
SM Armour, JR Remsberg, M Damle, S Sidoli, WY Ho, Z Li, BA Garcia, ...
Nature communications 8 (1), 1-11, 2017
612017
Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism
BP Hubbard, C Loh, AP Gomes, J Li, Q Lu, TLG Doyle, JS Disch, ...
Cell cycle 12 (14), 2233-2240, 2013
262013
Hepatic expression of GAA results in enhanced enzyme bioavailability in mice and non-human primates
H Costa-Verdera, F Collaud, CR Riling, P Sellier, JML Nordin, ...
Nature Communications 12 (1), 6393, 2021
142021
SPK-8016: Preliminary results from a phase 1/2 clinical trial of gene therapy for hemophilia A
SK Sullivan, JC Barrett, DA Drelich, MD Tarantino, A MacDougall, ...
Haemophilia 27, 129-130, 2021
102021
Preclinical assessment of an optimized AAV-FVIII vector in mice and non-human primates for the treatment of hemophilia A
L Elkouby, SM Armour, R Toso, M DiPietro, RJ Davidson, GN Nguyen, ...
Molecular Therapy-Methods & Clinical Development 24, 20-29, 2022
62022
Xenohormesis based compositions and methods
DA Sinclair, JA Baur, SM Armour
US Patent App. 12/087,641, 2010
52010
Methods and Compositions for Treatment Cell Proliferative Disorders
DA Sinclair, JA Baur, SM Armour
US Patent App. 12/087,631, 2009
52009
Compositions and methods for increasing or enhancing transduction of gene therapy vectors and for removing or reducing immunoglobulins
S Lacroix-Desmazes, F Mingozzi, J Dimitrov, C Leborgne, S Armour
US Patent App. 17/050,911, 2021
32021
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