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Claudèle Lemay-St-Denis
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Dual-target inhibitors of the folate pathway inhibit intrinsically trimethoprim-resistant DfrB dihydrofolate reductases
JL Toulouse, G Shi, C Lemay-St-Denis, MC Ebert, D Deon, M Gagnon, ...
ACS Medicinal Chemistry Letters 11 (11), 2261-2267, 2020
122020
The Bacterial Genomic Context of Highly Trimethoprim-Resistant DfrB Dihydrofolate Reductases Highlights An Emerging Threat to Public Health
C Lemay-St-Denis, SS Diwan, JN Pelletier
Antibiotics 10 (4), 433, 2021
112021
A conserved SH3-like fold in diverse putative proteins tetramerizes into an oxidoreductase providing an antimicrobial resistance phenotype
C Lemay-St-Denis, L Alejaldre, Z Jemouai, K Lafontaine, M St-Aubin, ...
Philosophical Transactions of the Royal Society B 378 (1871), 20220040, 2023
42023
Tuning selectivity in CalA lipase: beyond tunnel engineering
L Alejaldre, C Lemay-St-Denis, JN Pelletier, D Quaglia
Biochemistry 62 (2), 396-409, 2022
42022
Integrating dynamics into enzyme engineering
C Lemay-St-Denis, N Doucet, JN Pelletier
Protein Engineering, Design and Selection 35, gzac015, 2022
42022
Known evolutionary paths are accessible to engineered ß-lactamases having altered protein motions at the timescale of catalytic turnover
L Alejaldre, C Lemay-St-Denis, CP Lopez, FS Jodar, V Guallar, ...
Frontiers in molecular biosciences 7, 2020
32020
Computational identification of a multi-peptide vaccine candidate in E2 glycoprotein against diverse hepatitis c virus genotypes
S Kumari, A Kessel, D Singhal, G Kaur, D Bern, C Lemay-St-Denis, ...
Journal of Biomolecular Structure and Dynamics 41 (20), 11044-11061, 2023
22023
Trimethoprim resistance in surface and wastewater is mediated by contrasting variants of the dfrB gene
D Kneis, C Lemay-St-Denis, S Cellier-Goetghebeur, AX Elena, ...
The ISME Journal 17 (9), 1455-1466, 2023
22023
Discovery of Highly Trimethoprim-Resistant DfrB Dihydrofolate Reductases in Diverse Environmental Settings Suggests an Evolutionary Advantage Unrelated to Antibiotic Resistance
S Cellier-Goetghebeur, K Lafontaine, C Lemay-St-Denis, P Tsamo, ...
Antibiotics 11 (12), 1768, 2022
22022
From a binding module to essential catalytic activity: how nature stumbled on a good thing
C Lemay-St-Denis, JN Pelletier
Chemical Communications 59 (84), 12560-12572, 2023
12023
Development of sulfahydantoin derivatives as β-lactamase inhibitors
PA Paquet-Côté, L Alejaldre, CL Verreault, SMC Gobeil, R Lamoureux, ...
Bioorganic & Medicinal Chemistry Letters, 127781, 2021
12021
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