Daniel Coombs
Daniel Coombs
Professor, Mathematics, University of British Columbia
Verified email at math.ubc.ca - Homepage
Cited by
Cited by
Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time
M Aleksic, O Dushek, H Zhang, E Shenderov, JL Chen, V Cerundolo, ...
Immunity 32 (2), 163-174, 2010
Activated TCRs remain marked for internalization after dissociation from pMHC
D Coombs, AM Kalergis, SG Nathenson, C Wofsy, B Goldstein
Nature immunology 3 (10), 926-931, 2002
T cell receptor binding kinetics required for T cell activation depend on the density of cognate ligand on the antigen-presenting cell
PA González, LJ Carreño, D Coombs, JE Mora, E Palmieri, B Goldstein, ...
Proceedings of the National Academy of Sciences 102 (13), 4824-4829, 2005
An age-structured model of HIV infection that allows for variations in the production rate of viral particles and the death rate of productively infected cells
PW Nelson, MA Gilchrist, D Coombs, JM Hyman, AS Perelson
Math. Biosci. Eng 1 (2), 267-288, 2004
Evaluating the importance of within-and between-host selection pressures on the evolution of chronic pathogens
D Coombs, MA Gilchrist, CL Ball
Theoretical population biology 72 (4), 576-591, 2007
Evolution of virulence: interdependence, constraints, and selection using nested models
MA Gilchrist, D Coombs
Theoretical population biology 69 (2), 145-153, 2006
The influence of transport on the kinetics of binding to surface receptors: application to cells and BIAcore
B Goldstein, D Coombs, X He, AR Pineda, C Wofsy
Journal of molecular recognition 12 (5), 293-299, 1999
A hidden Markov model for single particle tracks quantifies dynamic interactions between LFA-1 and the actin cytoskeleton
R Das, CW Cairo, D Coombs
PLoS Comput Biol 5 (11), e1000556, 2009
Optimizing within-host viral fitness: infected cell lifespan and virion production rate
MA Gilchrist, D Coombs, AS Perelson
Journal of theoretical biology 229 (2), 281-288, 2004
Diffusion on a sphere with localized traps: Mean first passage time, eigenvalue asymptotics, and Fekete points
D Coombs, R Straube, M Ward
SIAM Journal on Applied Mathematics 70 (1), 302-332, 2009
Equilibrium thermodynamics of cell-cell adhesion mediated by multiple ligand-receptor pairs
D Coombs, M Dembo, C Wofsy, B Goldstein
Biophysical journal 86 (3), 1408-1423, 2004
A stochastic model of latently infected cell reactivation and viral blip generation in treated HIV patients
JM Conway, D Coombs
PLoS Comput Biol 7 (4), e1002033, 2011
Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor
SA Freeman, V Jaumouillé, K Choi, BE Hsu, HS Wong, L Abraham, ...
Nature communications 6, 6168, 2015
A role for rebinding in rapid and reliable T cell responses to antigen
O Dushek, R Das, D Coombs
PLoS Comput Biol 5 (11), e1000578, 2009
Calculations show substantial serial engagement of T cell receptors
C Wofsy, D Coombs, B Goldstein
Biophysical journal 80 (2), 606-612, 2001
Mechanical force regulates integrin turnover in Drosophila in vivo
M Pines, R Das, SJ Ellis, A Morin, S Czerniecki, L Yuan, M Klose, ...
Nature cell biology 14 (9), 935-943, 2012
Modeling within-host evolution of HIV: mutation, competition and strain replacement
CL Ball, MA Gilchrist, D Coombs
Bulletin of mathematical biology 69 (7), 2361-2385, 2007
Antigen potency and maximal efficacy reveal a mechanism of efficient T cell activation
O Dushek, M Aleksic, RJ Wheeler, H Zhang, SP Cordoba, YC Peng, ...
Science signaling 4 (176), ra39-ra39, 2011
Probability of a false-negative HIV antibody test result during the window period: a tool for pre-and post-test counselling
D Taylor, M Durigon, H Davis, C Archibald, B Konrad, D Coombs, ...
International journal of STD & AIDS 26 (4), 215-224, 2015
Effects of intracellular calcium and actin cytoskeleton on TCR mobility measured by fluorescence recovery
O Dushek, S Mueller, S Soubies, D Depoil, I Caramalho, D Coombs, ...
PloS one 3 (12), e3913, 2008
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