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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice M Citron, D Westaway, W Xia, G Carlson, T Diehl, G Levesque, ... Nature medicine 3 (1), 67-72, 1997 | 1849 | 1997 |
Skeletal and CNS defects in Presenilin-1-deficient mice J Shen, RT Bronson, DF Chen, W Xia, DJ Selkoe, S Tonegawa Cell 89 (4), 629-639, 1997 | 1238 | 1997 |
Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease LB Yang, K Lindholm, R Yan, M Citron, W Xia, XL Yang, T Beach, L Sue, ... Nature medicine 9 (1), 3-4, 2003 | 887 | 2003 |
Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1 WP Esler, WT Kimberly, BL Ostaszewski, TS Diehl, CL Moore, JY Tsai, ... Nature cell biology 2 (7), 428-434, 2000 | 755 | 2000 |
Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration A Salehi, JD Delcroix, PV Belichenko, K Zhan, C Wu, JS Valletta, ... Neuron 51 (1), 29-42, 2006 | 605 | 2006 |
The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production L Pastorino, A Sun, PJ Lu, XZ Zhou, M Balastik, G Finn, G Wulf, J Lim, ... Nature 440 (7083), 528-534, 2006 | 579 | 2006 |
Mutagenesis identifies new signals for β-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Aβ42 RG Perez, S Soriano, JD Hayes, B Ostaszewski, W Xia, DJ Selkoe, ... Journal of Biological Chemistry 274 (27), 18851-18856, 1999 | 543 | 1999 |
APP processing is regulated by cytoplasmic phosphorylation MS Lee, SC Kao, CA Lemere, W Xia, HC Tseng, Y Zhou, R Neve, ... The Journal of cell biology 163 (1), 83-95, 2003 | 539 | 2003 |
A detergent-insoluble membrance compartment contains Aβ in vivo SJ Lee, U Liyanage, PE Bickel, W Xia, PT Lansbury Jr, KS Kosik Nature medicine 4 (6), 730-734, 1998 | 484 | 1998 |
Presenilin proteins undergo heterogeneous endoproteolysis between Thr291and Ala299and occur as stable N-and C-terminal fragments in normal and Alzheimer brain tissue MB Podlisny, M Citron, P Amarante, R Sherrington, W Xia, J Zhang, ... Neurobiology of disease 3 (4), 325-337, 1997 | 417 | 1997 |
Peptidomimetic probes and molecular modeling suggest that Alzheimer's γ-secretase is an intramembrane-cleaving aspartyl protease MS Wolfe, W Xia, CL Moore, DD Leatherwood, B Ostaszewski, T Rahmati, ... Biochemistry 38 (15), 4720-4727, 1999 | 415 | 1999 |
The transmembrane aspartates in presenilin 1 and 2 are obligatory for γ-secretase activity and amyloid β-protein generation WT Kimberly, W Xia, T Rahmati, MS Wolfe, DJ Selkoe Journal of Biological Chemistry 275 (5), 3173-3178, 2000 | 405 | 2000 |
Presenilin-mediated modulation of capacitative calcium entry AS Yoo, I Cheng, S Chung, TZ Grenfell, H Lee, E Pack-Chung, M Handler, ... Neuron 27 (3), 561-572, 2000 | 396 | 2000 |
Enhanced production and oligomerization of the 42-residue amyloid β-protein by Chinese hamster ovary cells stably expressing mutant presenilins W Xia, J Zhang, D Kholodenko, M Citron, MB Podlisny, DB Teplow, ... Journal of Biological Chemistry 272 (12), 7977-7982, 1997 | 384 | 1997 |
Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease W Xia, J Zhang, R Perez, EH Koo, DJ Selkoe Proceedings of the National Academy of Sciences 94 (15), 8208-8213, 1997 | 350 | 1997 |
The common inhalational anesthetic sevoflurane induces apoptosis and increases β-amyloid protein levels Y Dong, G Zhang, B Zhang, RD Moir, W Xia, ER Marcantonio, DJ Culley, ... Archives of neurology 66 (5), 620-631, 2009 | 344 | 2009 |
The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid β-protein accumulation Z Xie, Y Dong, U Maeda, RD Moir, W Xia, DJ Culley, G Crosby, RE Tanzi Journal of Neuroscience 27 (6), 1247-1254, 2007 | 332 | 2007 |
Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease MS Wolfe, J De Los Angeles, DD Miller, W Xia, DJ Selkoe Biochemistry 38 (35), 11223-11230, 1999 | 305 | 1999 |
A substrate-based difluoro ketone selectively inhibits Alzheimer's γ-secretase activity MS Wolfe, M Citron, TS Diehl, W Xia, IO Donkor, DJ Selkoe Journal of medicinal chemistry 41 (1), 6-9, 1998 | 304 | 1998 |