Follow
Chris Kay
Chris Kay
Verified email at cmmt.ubc.ca
Title
Cited by
Cited by
Year
Huntington disease
GP Bates, R Dorsey, JF Gusella, MR Hayden, C Kay, BR Leavitt, M Nance, ...
Nature reviews Disease primers 1 (1), 1-21, 2015
16282015
Length of uninterrupted CAG, independent of polyglutamine size, results in increased somatic instability, hastening onset of Huntington disease
GEB Wright, JA Collins, C Kay, C McDonald, E Dolzhenko, Q Xia, ...
The American Journal of Human Genetics 104 (6), 1116-1126, 2019
1802019
Curation of the mammalian palmitoylome indicates a pivotal role for palmitoylation in diseases and disorders of the nervous system and cancers
SS Sanders, DDO Martin, SL Butland, M Lavallée-Adam, D Calzolari, ...
PLoS computational biology 11 (8), e1004405, 2015
1592015
A SNP in the HTT promoter alters NF-κB binding and is a bidirectional genetic modifier of Huntington disease
K Bečanović, A Nørremølle, SJ Neal, C Kay, JA Collins, D Arenillas, T Lilja, ...
Nature neuroscience 18 (6), 807-816, 2015
1472015
Huntingtin haplotypes provide prioritized target panels for allele-specific silencing in Huntington disease patients of European ancestry
C Kay, JA Collins, NH Skotte, AL Southwell, SC Warby, NS Caron, ...
Molecular Therapy 23 (11), 1759-1771, 2015
1172015
Huntington disease reduced penetrance alleles occur at high frequency in the general population
C Kay, JA Collins, Z Miedzybrodzka, SJ Madore, ES Gordon, N Gerry, ...
Neurology 87 (3), 282-288, 2016
1162016
An enhanced Q175 knock-in mouse model of Huntington disease with higher mutant huntingtin levels and accelerated disease phenotypes
AL Southwell, A Smith-Dijak, C Kay, M Sepers, EB Villanueva, ...
Human molecular genetics 25 (17), 3654-3675, 2016
1132016
Drosophila Muller F Elements Maintain a Distinct Set of Genomic Properties Over 40 Million Years of Evolution
W Leung, CD Shaffer, LK Reed, ST Smith, W Barshop, W Dirkes, ...
G3: Genes, Genomes, Genetics 5 (5), 719-740, 2015
1072015
CAG size-specific risk estimates for intermediate allele repeat instability in Huntington disease
A Semaka, C Kay, C Doty, JA Collins, EK Bijlsma, F Richards, ...
Journal of Medical Genetics 50 (10), 696-703, 2013
1002013
Epidemiology of Huntington disease
C Kay, MR Hayden, BR Leavitt
Handbook of clinical neurology 144, 31-46, 2017
822017
Personalized gene silencing therapeutics for Huntington disease
C Kay, NH Skotte, AL Southwell, MR Hayden
Clinical genetics 86 (1), 29-36, 2014
792014
Huntington disease in the South African population occurs on diverse and ethnically distinct genetic haplotypes
FK Baine, C Kay, ME Ketelaar, JA Collins, A Semaka, CN Doty, A Krause, ...
European Journal of Human Genetics 21 (10), 1120-1127, 2013
772013
The molecular epidemiology of Huntington disease is related to intermediate allele frequency and haplotype in the general population
C Kay, JA Collins, GEB Wright, F Baine, Z Miedzybrodzka, F Aminkeng, ...
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 177 …, 2018
762018
High frequency of intermediate alleles on Huntington disease‐associated haplotypes in British Columbia's general population
A Semaka, C Kay, CN Doty, JA Collins, N Tam, MR Hayden
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 162 …, 2013
572013
Frequency of the loss of CAA interruption in the HTT CAG tract and implications for Huntington disease in the reduced penetrance range
HF Black, GEB Wright, JA Collins, N Caron, C Kay, Q Xia, L Arning, ...
Genetics in Medicine 22 (12), 2108-2113, 2020
472020
A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles
AL Southwell, NH Skotte, EB Villanueva, ME Østergaard, X Gu, ...
Human Molecular Genetics 26 (6), 1115-1132, 2017
402017
A human huntingtin SNP alters post-translational modification and pathogenic proteolysis of the protein causing Huntington disease
DDO Martin, C Kay, JA Collins, YT Nguyen, RA Slama, MR Hayden
Scientific Reports 8 (1), 8096, 2018
382018
A comprehensive haplotype-targeting strategy for allele-specific HTT suppression in Huntington disease
C Kay, JA Collins, NS Caron, L de Andrade Agostinho, H Findlay-Black, ...
The American Journal of Human Genetics 105 (6), 1112-1125, 2019
332019
A new mutation for Huntington disease following maternal transmission of an intermediate allele
A Semaka, C Kay, RDM Belfroid, EK Bijlsma, M Losekoot, IM van Langen, ...
European journal of medical genetics 58 (1), 28-30, 2015
242015
The targetable A1 Huntington disease haplotype has distinct Amerindian and European origins in Latin America
C Kay, I Tirado-Hurtado, M Cornejo-Olivas, JA Collins, G Wright, ...
European Journal of Human Genetics 25 (3), 332-340, 2017
232017
The system can't perform the operation now. Try again later.
Articles 1–20