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Nicholas Leiby
Nicholas Leiby
Research Scientist at Two Six Labs
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Cited by
Year
Metabolic resource allocation in individual microbes determines ecosystem interactions and spatial dynamics
WR Harcombe, WJ Riehl, I Dukovski, BR Granger, A Betts, AH Lang, ...
Cell reports 7 (4), 1104-1115, 2014
5042014
Parallel bacterial evolution within multiple patients identifies candidate pathogenicity genes
TD Lieberman, JB Michel, M Aingaran, G Potter-Bynoe, D Roux, ...
Nature genetics 43 (12), 1275-1280, 2011
4312011
Epistasis and allele specificity in the emergence of a stable polymorphism in Escherichia coli
J Plucain, T Hindré, M Le Gac, O Tenaillon, S Cruveiller, C Médigue, ...
Science 343 (6177), 1366-1369, 2014
1452014
Metabolic Erosion Primarily Through Mutation Accumulation, and Not Tradeoffs, Drives Limited Evolution of Substrate Specificity in Escherichia coli
N Leiby, CJ Marx
PLoS biology 12 (2), e1001789, 2014
1402014
The ability of flux balance analysis to predict evolution of central metabolism scales with the initial distance to the optimum
WR Harcombe, NF Delaney, N Leiby, N Klitgord, CJ Marx
PLoS computational biology 9 (6), e1003091, 2013
952013
Metabolic resource allocation in individual microbes determines ecosystem interactions and spatial dynamics. Cell Rep 7: 1104–1115
WR Harcombe, WJ Riehl, I Dukovski, BR Granger, A Betts, AH Lang, ...
372014
Large-scale design and refinement of stable proteins using sequence-only models
JM Singer, S Novotney, D Strickland, HK Haddox, N Leiby, GJ Rocklin, ...
PloS one 17 (3), e0265020, 2022
242022
New guidance for using t-SNE: Alternative defaults, hyperparameter selection automation, and comparative evaluation
R Gove, L Cadalzo, N Leiby, JM Singer, A Zaitzeff
Visual Informatics 6 (2), 87-97, 2022
182022
Multiple long-term, experimentally-evolved populations of Escherichia coliacquire dependence upon citrate as an iron chelator for optimal growth on glucose
N Leiby, WR Harcombe, CJ Marx
BMC evolutionary biology 12, 1-9, 2012
162012
Hyperparameter optimization of topological features for machine learning applications
F Motta, C Tralie, R Bedini, F Bini, G Bini, H Eramian, M Gameiro, ...
2019 18th IEEE international conference on machine learning and applications …, 2019
52019
Adaptation and specialization in the evolution of bacterial metabolism
N Leiby
42014
Improved datasets and evaluation methods for the automatic prediction of DNA-binding proteins
A Zaitzeff, N Leiby, FC Motta, SB Haase, JM Singer
Bioinformatics 38 (1), 44-51, 2022
32022
Spatiotemporal Route to Understanding Metal Halide Perovskitoid Crystallization
MAN Nellikkal, R Keesey, M Zeile, V Shekar, Z Li, N Leiby, M Zeller, ...
Chemistry of Materials 34 (12), 5386-5396, 2022
22022
Convolutional neural net learns promoter sequence features driving transcription strength
N Leiby, A Hossain, HM Salis
Proceedings of the 12th International Conference Bioinformatics and …, 2020
2*2020
A spatiotemporal route to understanding metal halide perovskite crystallization
MA Najeeb, R Keesey, M Zeile, V Shekar, Z Li, N Leiby, M Zeller, E Chan, ...
2022
155. Modeling metabolic dynamics in 3D: applications to synthetic microbial ecosystems
WR Harcombe, W Riehl, I Dukovski, BR Granger, A Betts, AH Lang, ...
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