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Therapeutically effective antibodies against amyloid-β peptide target amyloid-β residues 4–10 and inhibit cytotoxicity and fibrillogenesis J McLaurin, R Cecal, ME Kierstead, X Tian, AL Phinney, M Manea, ... Nature medicine 8 (11), 1263-1269, 2002 | 567 | 2002 |
Interactions between β-amyloid and central cholinergic neurons: implications for Alzheimer’s disease S Kar, SPM Slowikowski, D Westaway, HTJ Mount Journal of Psychiatry and Neuroscience 29 (6), 427-441, 2004 | 491 | 2004 |
Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse model JA McLaurin, ME Kierstead, ME Brown, CA Hawkes, MHL Lambermon, ... Nature medicine 12 (7), 801-808, 2006 | 452 | 2006 |
Brain-derived neurotrophic factor rapidly enhances phosphorylation of the postsynaptic N-methyl-d-aspartate receptor subunit 1 PC Suen, K Wu, ES Levine, HTJ Mount, JL Xu, SY Lin, IB Black Proceedings of the National Academy of Sciences 94 (15), 8191-8195, 1997 | 373 | 1997 |
BDNF acutely increases tyrosine phosphorylation of the NMDA receptor subunit 2B in cortical and hippocampal postsynaptic densities SY Lin, K Wu, ES Levine, HTJ Mount, PC Suen, IB Black Molecular brain research 55 (1), 20-27, 1998 | 340 | 1998 |
α5GABAA receptors mediate the amnestic but not sedative-hypnotic effects of the general anesthetic etomidate VY Cheng, LJ Martin, EM Elliott, JH Kim, HTJ Mount, FA Taverna, ... Journal of Neuroscience 26 (14), 3713-3720, 2006 | 294 | 2006 |
Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of β-catenin, a component of the presenilin protein complex M Nishimura, G Yu, G Levesque, DM Zhang, L Ruel, F Chen, P Milman, ... Nature medicine 5 (2), 164-169, 1999 | 276 | 1999 |
Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease S Peng, DJ Garzon, M Marchese, W Klein, SD Ginsberg, BM Francis, ... Journal of Neuroscience 29 (29), 9321-9329, 2009 | 245 | 2009 |
Glial cell line-derived neurotrophic factor promotes the survival and morphologic differentiation of Purkinje cells. HTJ Mount, DO Dean, J Alberch, CF Dreyfus, IB Black Proceedings of the National Academy of Sciences 92 (20), 9092-9096, 1995 | 221 | 1995 |
Glial cell line-derived neurotrophic factor promotes the survival and morphologic differentiation of Purkinje cells. HTJ Mount, DO Dean, J Alberch, CF Dreyfus, IB Black Proceedings of the National Academy of Sciences 92 (20), 9092-9096, 1995 | 221 | 1995 |
APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin· nicastrin complexes Y Gu, F Chen, N Sanjo, T Kawarai, H Hasegawa, M Duthie, W Li, X Ruan, ... Journal of Biological Chemistry 278 (9), 7374-7380, 2003 | 212 | 2003 |
Mature Glycosylation and Trafficking of Nicastrin Modulate Its Binding to Presenilins* 210 DS Yang, A Tandon, F Chen, G Yu, H Yu, S Arawaka, H Hasegawa, ... Journal of Biological Chemistry 277 (31), 28135-28142, 2002 | 208 | 2002 |
Unesterified docosahexaenoic acid is protective in neuroinflammation SK Orr, S Palumbo, F Bosetti, HT Mount, JX Kang, CE Greenwood, ... Journal of neurochemistry 127 (3), 378-393, 2013 | 178 | 2013 |
The CNS glycoprotein Shadoo has PrPC‐like protective properties and displays reduced levels in prion infections JC Watts, B Drisaldi, V Ng, J Yang, B Strome, P Horne, MS Sy, L Yoong, ... The EMBO journal 26 (17), 4038-4050, 2007 | 173 | 2007 |
Reduced fear and aggression and altered serotonin metabolism in Gtf2ird1‐targeted mice EJ Young, T Lipina, E Tam, A Mandel, SJ Clapcote, AR Bechard, ... Genes, Brain and Behavior 7 (2), 224-234, 2008 | 166 | 2008 |
Inflammatory biomarkers in Alzheimer's disease plasma AR Morgan, S Touchard, C Leckey, C O'Hagan, AJ Nevado-Holgado, ... Alzheimer's & dementia 15 (6), 776-787, 2019 | 139 | 2019 |
Presenilin 1 mutations activate γ42-secretase but reciprocally inhibit ε-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch F Chen, YJ Gu, H Hasegawa, X Ruan, S Arawaka, P Fraser, D Westaway, ... Journal of Biological Chemistry 277 (39), 36521-36526, 2002 | 138 | 2002 |
Functional trkB neurotrophin receptors are intrinsic components of the adult brain postsynaptic density K Wu, J Xu, P Suen, E Levine, Y Huang, HTJ Mount, S Lin, IB Black Molecular brain research 43 (1-2), 286-290, 1996 | 135 | 1996 |
Object recognition memory and BDNF expression are reduced in young TgCRND8 mice BM Francis, J Kim, ME Barakat, S Fraenkl, YH Yücel, S Peng, B Michalski, ... Neurobiology of aging 33 (3), 555-563, 2012 | 129 | 2012 |