SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids J Jansen, KC Reimer, JS Nagai, FS Varghese, GJ Overheul, M de Beer, ... Cell Stem Cell 29 (2), 217-231. e8, 2022 | 174 | 2022 |
PAINS: Relevance to tool compound discovery and fragment-based screening JB Baell, L Ferrins, H Falk, G Nikolakopoulos Australian Journal of Chemistry 66 (12), 1483-1494, 2013 | 97 | 2013 |
Pyridyl Benzamides as a Novel Class of Potent Inhibitors for the Kinetoplastid Trypanosoma brucei L Ferrins, M Gazdik, R Rahmani, S Varghese, ML Sykes, AJ Jones, ... Journal of medicinal chemistry 57 (15), 6393-6402, 2014 | 60 | 2014 |
Nuisance compounds in cellular assays JL Dahlin, DS Auld, I Rothenaigner, S Haney, JZ Sexton, JWM Nissink, ... Cell chemical biology 28 (3), 356-370, 2021 | 44 | 2021 |
Hit-to-lead optimization of a novel class of potent, broad-spectrum trypanosomacides S Russell, R Rahmani, AJ Jones, HL Newson, K Neilde, I Cotillo, ... Journal of medicinal chemistry 59 (21), 9686-9720, 2016 | 39 | 2016 |
Drug discovery and human African trypanosomiasis: a disease less neglected? L Ferrins, R Rahmani, JB Baell Future medicinal chemistry 5 (15), 1801-1841, 2013 | 39 | 2013 |
3-(Oxazolo [4, 5-b] pyridin-2-yl) anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis L Ferrins, R Rahmani, ML Sykes, AJ Jones, VM Avery, E Teston, ... European journal of medicinal chemistry 66, 450-465, 2013 | 39 | 2013 |
Open Science Discovery of Potent Non-Covalent SARS-CoV-2 Main Protease Inhibitors COVID Moonshot Consortium, H Achdout, A Aimon, DS Alonzi, R Arbon, ... BioRxiv, 2020.10. 29.339317, 2020 | 36 | 2020 |
Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2 BC Sanders, S Pokhrel, AD Labbe, II Mathews, CJ Cooper, RB Davidson, ... Nature communications 14 (1), 1733, 2023 | 34 | 2023 |
A diverse view of science to catalyse change CA Urbina-Blanco, SZ Jilani, IR Speight, MJ Bojdys, T Friscic, JF Stoddart, ... Journal of the American Chemical Society 142 (34), 14393-14396, 2020 | 32 | 2020 |
Metabolomics and lipidomics reveal perturbation of sphingolipid metabolism by a novel anti-trypanosomal 3-(oxazolo[4,5-b]pyridine-2-yl)anilide D Stoessel, CJ Nowell, AJ Jones, L Ferrins, KM Ellis, J Riley, R Rahmani, ... Metabolomics 12, 1-14, 2016 | 29 | 2016 |
Improvement of aqueous solubility of lapatinib-derived analogues: identification of a quinolinimine lead for human African trypanosomiasis drug development KA Bachovchin, A Sharma, S Bag, DM Klug, KM Schneider, B Singh, ... Journal of medicinal chemistry 62 (2), 665-687, 2018 | 28 | 2018 |
Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors ML Boby, D Fearon, M Ferla, M Filep, L Koekemoer, MC Robinson, ... Science 382 (6671), eabo7201, 2023 | 26 | 2023 |
6-Arylpyrazine-2-carboxamides: A New Core for Trypanosoma brucei Inhibitors R Rahmani, K Ban, AJ Jones, L Ferrins, D Ganame, ML Sykes, VM Avery, ... Journal of medicinal chemistry 58 (17), 6753-6765, 2015 | 25 | 2015 |
Scaffold and parasite hopping: discovery of new protozoal proliferation inhibitors B Singh, JA Bernatchez, LI McCall, CM Calvet, J Ackermann, JM Souza, ... ACS Medicinal Chemistry Letters 11 (3), 249-257, 2020 | 19 | 2020 |
The importance of collaboration between industry, academics, and nonprofits in tropical disease drug discovery L Ferrins, MP Pollastri ACS infectious diseases 4 (4), 445-448, 2017 | 17 | 2017 |
Discovery of Potent N-Ethylurea Pyrazole Derivatives as Dual Inhibitors of Trypanosoma brucei and Trypanosoma cruzi S Varghese, R Rahmani, S Russell, GS Deora, L Ferrins, A Toynton, ... ACS Medicinal Chemistry Letters 11 (3), 278-285, 2019 | 16 | 2019 |
Optimization of Physicochemical Properties for 4-Anilinoquinoline Inhibitors of Plasmodium falciparum Proliferation N Mehta, L Ferrins, SE Leed, RJ Sciotti, MP Pollastri ACS infectious diseases 4 (4), 577-591, 2018 | 16 | 2018 |
Selectivity and Physicochemical Optimization of Repurposed Pyrazolo[1,5-b]pyridazines for the Treatment of Human African Trypanosomiasis WF Tear, S Bag, R Diaz-Gonzalez, G Ceballos-Pérez, DI Rojas-Barros, ... Journal of Medicinal Chemistry 63 (2), 756-783, 2019 | 15 | 2019 |
Hit-to-lead optimization of benzoxazepinoindazoles as human African trypanosomiasis therapeutics DM Klug, L Tschiegg, R Diaz, D Rojas-Barros, G Perez-Moreno, ... Journal of medicinal chemistry 63 (5), 2527-2546, 2019 | 11 | 2019 |