Harold Saavedra
Harold Saavedra
Associate Professor, Ponce Health Sciences University
Verified email at psm.edu
Title
Cited by
Cited by
Year
The E2F1–3 transcription factors are essential for cellular proliferation
L Wu, C Timmers, B Maiti, HI Saavedra, L Sang, GT Chong, F Nuckolls, ...
Nature 414 (6862), 457-462, 2001
6182001
Extra-embryonic function of Rb is essential for embryonic development and viability
L Wu, A de Bruin, HI Saavedra, M Starovic, A Trimboli, Y Yang, J Opavska, ...
Nature 421 (6926), 942-947, 2003
4032003
Myc requires distinct E2F activities to induce S phase and apoptosis
G Leone, R Sears, E Huang, R Rempel, F Nuckolls, CH Park, ...
Molecular cell 8 (1), 105-113, 2001
2652001
Aberrant regulation of survivin by the RB/E2F family of proteins
Y Jiang, HI Saavedra, MP Holloway, G Leone, RA Altura
Journal of Biological Chemistry 279 (39), 40511-40520, 2004
2052004
The RAS oncogene induces genomic instability in thyroid PCCL3 cells via the MAPK pathway
HI Saavedra, JA Knauf, JM Shirokawa, J Wang, B Ouyang, R Elisei, ...
Oncogene 19 (34), 3948-3954, 2000
1992000
Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb-deficient mice
A de Bruin, L Wu, HI Saavedra, P Wilson, Y Yang, TJ Rosol, M Weinstein, ...
Proceedings of the National Academy of Sciences 100 (11), 6546-6551, 2003
1492003
Specificity of E2F1, E2F2, and E2F3 in mediating phenotypes induced by loss of Rb
HI Saavedra, L Wu, A de Bruin, C Timmers, TJ Rosol, M Weinstein, ...
Cell Growth and Differentiation-Publication American Association for Cancer …, 2002
1132002
E2f1, E2f2, and E2f3 control E2F target expression and cellular proliferation via a p53-dependent negative feedback loop
C Timmers, N Sharma, R Opavsky, B Maiti, L Wu, J Wu, D Orringer, ...
Molecular and cellular biology 27 (1), 65-78, 2007
1092007
MAPK mediates RAS-induced chromosome instability
HI Saavedra, K Fukasawa, CW Conn, PJ Stambrook
Journal of Biological Chemistry 274 (53), 38083-38090, 1999
1021999
Inactivation of E2F3 results in centrosome amplification
HI Saavedra, B Maiti, C Timmers, R Altura, Y Tokuyama, K Fukasawa, ...
Cancer cell 3 (4), 333-346, 2003
902003
Cdk2 and Cdk4 regulate the centrosome cycle and are critical mediators of centrosome amplification in p53-null cells
AM Adon, X Zeng, MK Harrison, S Sannem, H Kiyokawa, P Kaldis, ...
Molecular and cellular biology 30 (3), 694-710, 2010
852010
Control of the p53-p21CIP1 Axis by E2f1, E2f2, and E2f3 is essential for G1/S progression and cellular transformation
N Sharma, C Timmers, P Trikha, HI Saavedra, A Obery, G Leone
Journal of Biological Chemistry 281 (47), 36124-36131, 2006
762006
The Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2
X Zeng, FY Shaikh, MK Harrison, AM Adon, AJ Trimboli, KA Carroll, ...
Oncogene 29 (36), 5103-5112, 2010
742010
Nek2 and Plk4: prognostic markers, drivers of breast tumorigenesis and drug resistance
M Marina, HI Saavedra
Frontiers in bioscience (Landmark edition) 19, 352, 2014
682014
Conditional apoptosis induced by oncogenic ras in thyroid cells
JM Shirokawa, R Elisei, JA Knauf, T Hara, J Wang, HI Saavedra, JA Fagin
Molecular Endocrinology 14 (11), 1725-1738, 2000
642000
Alloantigen gene therapy for squamous cell carcinoma of the head and neck: results of a phase 1 trial
LL Gleich, JL Gluckman, S Armstrong, PW Biddinger, MA Miller, ...
Archives of Otolaryngology–Head & Neck Surgery 124 (10), 1097-1104, 1998
621998
Management implications of evaluating the N2 and N3 neck after organ preservation therapy
MD Strasser, LL Gleich, MA Miller, HI Saavedra, JL Gluckman
The Laryngoscope 109 (11), 1776-1780, 1999
471999
The G 1 phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification
MK Harrison, AM Adon, HI Saavedra
Cell division 6 (1), 1-13, 2011
382011
E2F activators signal and maintain centrosome amplification in breast cancer cells
MY Lee, CS Moreno, HI Saavedra
Molecular and cellular biology 34 (14), 2581-2599, 2014
292014
Poldip2 knockout results in perinatal lethality, reduced cellular growth and increased autophagy of mouse embryonic fibroblasts
DI Brown, B Lassègue, M Lee, R Zafari, JS Long, HI Saavedra, ...
PLoS One 9 (5), e96657, 2014
292014
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