Mark Mabanglo
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Mitochondrial ClpP-mediated proteolysis induces selective cancer cell lethality
J Ishizawa, SF Zarabi, RE Davis, O Halgas, T Nii, Y Jitkova, R Zhao, ...
Cancer cell 35 (5), 721-737. e9, 2019
The role of ClpP protease in bacterial pathogenesis and human diseases
V Bhandari, KS Wong, JL Zhou, MF Mabanglo, RA Batey, WA Houry
ACS chemical biology 13 (6), 1413-1425, 2018
Acyldepsipeptide analogs dysregulate human mitochondrial ClpP protease activity and cause apoptotic cell death
KS Wong, MF Mabanglo, TV Seraphim, A Mollica, YQ Mao, K Rizzolo, ...
Cell chemical biology 25 (8), 1017-1030. e9, 2018
Variants of phosphotriesterase for the enhanced detoxification of the chemical warfare agent VR
AN Bigley, MF Mabanglo, SP Harvey, FM Raushel
Biochemistry 54 (35), 5502-5512, 2015
Reversible inhibition of the ClpP protease via an N-terminal conformational switch
S Vahidi, ZA Ripstein, M Bonomi, T Yuwen, MF Mabanglo, JB Juravsky, ...
Proceedings of the National Academy of Sciences 115 (28), E6447-E6456, 2018
X-ray structures of isopentenyl phosphate kinase
MF Mabanglo, HL Schubert, M Chen, CP Hill, CD Poulter
ACS chemical biology 5 (5), 517-527, 2010
Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal …
MF Mabanglo, MA Hast, NB Lubock, HW Hellinga, LS Beese
Protein Science 23 (3), 289-301, 2014
Structure of a Novel Phosphotriesterase from Sphingobium sp. TCM1: A Familiar Binuclear Metal Center Embedded in a Seven-Bladed β-Propeller Protein Fold
MF Mabanglo, DF Xiang, AN Bigley, FM Raushel
Biochemistry 55 (28), 3963-3974, 2016
Recent structural insights into the mechanism of ClpP protease regulation by AAA+ chaperones and small molecules
MF Mabanglo, WA Houry
Journal of Biological Chemistry 298 (5), 101781, 2022
ClpP protease activation results from the reorganization of the electrostatic interaction networks at the entrance pores
MF Mabanglo, E Leung, S Vahidi, TV Seraphim, BT Eger, S Bryson, ...
Communications biology 2 (1), 410, 2019
Development of Antibiotics That Dysregulate the Neisserial ClpP Protease
G Binepal, MF Mabanglo, JD Goodreid, E Leung, MM Barghash, ...
ACS infectious diseases 6 (12), 3224-3236, 2020
Substrates and interactors of the ClpP protease in the mitochondria
MF Mabanglo, V Bhandari, WA Houry
Current Opinion in Chemical Biology 66, 102078, 2022
Structure and reaction mechanism of the LigJ hydratase: an enzyme critical for the bacterial degradation of lignin in the protocatechuate 4, 5-cleavage pathway
TN Hogancamp, MF Mabanglo, FM Raushel
Biochemistry 57 (40), 5841-5850, 2018
Mutagenesis of isopentenyl phosphate kinase to enhance geranyl phosphate kinase activity
MF Mabanglo, JJ Pan, B Shakya, CD Poulter
ACS chemical biology 7 (7), 1241-1246, 2012
The Streptomyces-Produced Antibiotic Fosfomycin Is a Promiscuous Substrate for Archaeal Isopentenyl Phosphate Kinase
MF Mabanglo, AWR Serohijos, CD Poulter
Biochemistry 51 (4), 917-925, 2012
Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome
MF Mabanglo, KS Wong, MM Barghash, E Leung, SHW Chuang, ...
Structure 31 (2), 185-200. e10, 2023
Development of small molecules to modulate the activity of the ATP-dependent ClpP protease as a novel antibacterial and anticancer drug target
F Lin, MF Mabanglo, WA Houry, RA Batey
2019 Medicinal Chemistry Reviews 54, 379-404, 2019
Structure and reaction mechanism of YcjR, an epimerase that facilitates the intercorversion of D-gulosides to D-glucosides in Escherichia coli
MF Mabanglo, JP Huddleston, K Mukherjee, ZW Taylor, FM Raushel
Biochemistry, 2020
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