mark mabanglo
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Mitochondrial ClpP-mediated proteolysis induces selective cancer cell lethality
J Ishizawa, SF Zarabi, RE Davis, O Halgas, T Nii, Y Jitkova, R Zhao, ...
Cancer cell 35 (5), 721-737. e9, 2019
The role of ClpP protease in bacterial pathogenesis and human diseases
V Bhandari, KS Wong, JL Zhou, MF Mabanglo, RA Batey, WA Houry
ACS chemical biology 13 (6), 1413-1425, 2018
Acyldepsipeptide analogs dysregulate human mitochondrial ClpP protease activity and cause apoptotic cell death
KS Wong, MF Mabanglo, TV Seraphim, A Mollica, YQ Mao, K Rizzolo, ...
Cell chemical biology 25 (8), 1017-1030. e9, 2018
Variants of phosphotriesterase for the enhanced detoxification of the chemical warfare agent VR
AN Bigley, MF Mabanglo, SP Harvey, FM Raushel
Biochemistry 54 (35), 5502-5512, 2015
Reversible inhibition of the ClpP protease via an N-terminal conformational switch
S Vahidi, ZA Ripstein, M Bonomi, T Yuwen, MF Mabanglo, JB Juravsky, ...
Proceedings of the National Academy of Sciences 115 (28), E6447-E6456, 2018
X-ray structures of isopentenyl phosphate kinase
MF Mabanglo, HL Schubert, M Chen, CP Hill, CD Poulter
ACS chemical biology 5 (5), 517-527, 2010
Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal …
MF Mabanglo, MA Hast, NB Lubock, HW Hellinga, LS Beese
Protein Science 23 (3), 289-301, 2014
Structure of a Novel Phosphotriesterase from Sphingobium sp. TCM1: A Familiar Binuclear Metal Center Embedded in a Seven-Bladed β-Propeller Protein Fold
MF Mabanglo, DF Xiang, AN Bigley, FM Raushel
Biochemistry 55 (28), 3963-3974, 2016
ClpP protease activation results from the reorganization of the electrostatic interaction networks at the entrance pores
MF Mabanglo, E Leung, S Vahidi, TV Seraphim, BT Eger, S Bryson, ...
Communications Biology 2 (1), 410, 2019
Development of Antibiotics That Dysregulate the Neisserial ClpP Protease
G Binepal, MF Mabanglo, JD Goodreid, E Leung, MM Barghash, ...
ACS infectious diseases 6 (12), 3224-3236, 2020
Mutagenesis of isopentenyl phosphate kinase to enhance geranyl phosphate kinase activity
MF Mabanglo, JJ Pan, B Shakya, CD Poulter
ACS chemical biology 7 (7), 1241-1246, 2012
The Streptomyces-Produced Antibiotic Fosfomycin Is a Promiscuous Substrate for Archaeal Isopentenyl Phosphate Kinase
MF Mabanglo, AWR Serohijos, CD Poulter
Biochemistry 51 (4), 917-925, 2012
Recent structural insights into the mechanism of ClpP protease regulation by AAA+ chaperones and small molecules
MF Mabanglo, WA Houry
Journal of Biological Chemistry, 101781, 2022
Structure and reaction mechanism of the LigJ hydratase: an enzyme critical for the bacterial degradation of lignin in the protocatechuate 4, 5-cleavage pathway
TN Hogancamp, MF Mabanglo, FM Raushel
Biochemistry 57 (40), 5841-5850, 2018
Substrates and interactors of the ClpP protease in the mitochondria
MF Mabanglo, V Bhandari, WA Houry
Current opinion in chemical biology 66, 102078, 2022
Development of small molecules to modulate the activity of the ATP-dependent ClpP protease as a novel antibacterial and anticancer drug target
F Lin, MF Mabanglo, WA Houry, RA Batey
2019 Medicinal Chemistry Reviews 54, 379-404, 2019
Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome
MF Mabanglo, KS Wong, MM Barghash, E Leung, SHW Chuang, ...
Structure, 2022
Methods for treating cancer with acyldepsipeptide analogs
WA Houry, RA Batey, MF Mabanglo, JD Goodreid, KS Wong
US Patent App. 15/734,185, 2021
Structure and reaction mechanism of YcjR, an epimerase that facilitates the intercorversion of D-gulosides to D-glucosides in Escherichia coli
MF Mabanglo, JP Huddleston, K Mukherjee, ZW Taylor, FM Raushel
Biochemistry, 2020
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