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James Christopher Heaton
James Christopher Heaton
Principal Scientist, Pfizer R&D UK Ltd, Sandwich, UK
Adresse e-mail validée de pfizer.com - Page d'accueil
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Evidence of altered phosphatidylcholine metabolism in Alzheimer's disease
L Whiley, A Sen, J Heaton, P Proitsi, D García-Gómez, R Leung, N Smith, ...
Neurobiology of aging 35 (2), 271-278, 2014
3082014
Practical investigation of the factors that affect the selectivity in hydrophilic interaction chromatography
A Kumar, JC Heaton, DV McCalley
Journal of Chromatography A 1276, 33-46, 2013
1382013
Some factors that can lead to poor peak shape in hydrophilic interaction chromatography, and possibilities for their remediation
JC Heaton, DV McCalley
Journal of Chromatography A 1427, 37-44, 2016
932016
Comparison of peak shape in hydrophilic interaction chromatography using acidic salt buffers and simple acid solutions
JC Heaton, JJ Russell, T Underwood, R Boughtflower, DV McCalley
Journal of Chromatography A 1347, 39-48, 2014
682014
Comparison of reversed-phase and hydrophilic interaction liquid chromatography for the separation of ephedrines
J Heaton, N Gray, DA Cowan, RS Plumb, C Legido-Quigley, NW Smith
Journal of Chromatography A 1228, 329-337, 2012
672012
Comparison of reversed-phase and hydrophilic interaction liquid chromatography for the quantification of ephedrines using medium-resolution accurate mass spectrometry
N Gray, J Heaton, A Musenga, DA Cowan, RS Plumb, NW Smith
Journal of Chromatography A 1289, 37-46, 2013
642013
Genetic epidemiology of induced CYP3A4 activity
N Rahmioglu, J Heaton, G Clement, R Gill, G Surdulescu, K Zlobecka, ...
Pharmacogenetics and genomics 21 (10), 642-651, 2011
622011
Maximizing peak capacity and separation speed in liquid chromatography
P Petersson, A Frank, J Heaton, MR Euerby
Journal of separation science 31 (13), 2346-2357, 2008
612008
Practical observations on the performance of bare silica in hydrophilic interaction compared with C18 reversed-phase liquid chromatography
JC Heaton, X Wang, WE Barber, SMC Buckenmaier, DV McCalley
Journal of Chromatography A 1328, 7-15, 2014
552014
Integrated Analytical and Statistical Two-Dimensional Spectroscopy Strategy for Metabolite Identification: Application to Dietary Biomarkers
JM Posma, I Garcia-Perez, JC Heaton, P Burdisso, JC Mathers, J Draper, ...
Analytical Chemistry 89 (6), 3300-3309, 2017
532017
Comparison of the kinetic performance and retentivity of sub-2μm core–shell, hybrid and conventional bare silica phases in hydrophilic interaction chromatography
JC Heaton, DV McCalley
Journal of Chromatography A 1371, 106-116, 2014
402014
Performance of charged aerosol detection with hydrophilic interaction chromatography
JJ Russell, JC Heaton, T Underwood, R Boughtflower, DV McCalley
Journal of Chromatography A 1405, 72-84, 2015
322015
UV gradient combined with principal component analysis: Highly sensitive and specific high performance liquid chromatography analysis of cosmetic creams
W Gao, N Gray, J Heaton, NW Smith, Y Jia, C Legido-Quigley
Journal of Chromatography A 1228, 324-328, 2012
292012
Prediction of Variability in CYP3A4 Induction Using a Combined 1H NMR Metabonomics and Targeted UPLC–MS Approach
N Rahmioglu, G Le Gall, J Heaton, KL Kay, NW Smith, IJ Colquhoun, ...
Journal of proteome research 10 (6), 2807-2816, 2011
292011
Advantages and disadvantages of HILIC; a brief overview
J Heaton, NW Smith
Chromatogr. Today 5, 44-7, 2012
232012
Monolithic poly (SPE-co-BVPE) capillary columns as a novel hydrophilic interaction liquid chromatography stationary phase for the separation of polar analytes
HC Foo, J Heaton, NW Smith, S Stanley
Talanta 100, 344-348, 2012
202012
Systematic evaluation of acetone and acetonitrile for use in hydrophilic interaction liquid chromatography coupled with electrospray ionization mass spectrometry of basic small …
J Heaton, MD Jones, C Legido‐Quigley, RS Plumb, NW Smith
Rapid Communications in Mass Spectrometry 25 (24), 3666-3674, 2011
192011
Retention characteristics of some antibiotic and anti-retroviral compounds in hydrophilic interaction chromatography using isocratic elution, and gradient elution with …
JC Heaton, NW Smith, DV McCalley
Analytica chimica acta 1045, 141-151, 2019
162019
Evaluation of Chinese medicinal herbs fingerprinting by HPLC‐DAD for the detection of toxic aristolochic acids
J Heaton, L Whiley, Y Hong, C Mary Sebastian, N William Smith, ...
Journal of separation science 34 (10), 1111-1115, 2011
162011
Structure Driven Prediction of Chromatographic Retention Times: Applications to Pharmaceutical Analysis
R Szucs, R Brown, C Brunelli, JC Heaton, J Hradski
International Journal of Molecular Sciences 22 (8), 3848, 2021
142021
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