| An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1 CC Thoreen, SA Kang, JW Chang, Q Liu, J Zhang, Y Gao, LJ Reichling, ... Journal of Biological Chemistry 284 (12), 8023-8032, 2009 | 2029 | 2009 |
| Targeting transcription regulation in cancer with a covalent CDK7 inhibitor N Kwiatkowski, T Zhang, PB Rahl, BJ Abraham, J Reddy, SB Ficarro, ... Nature 511 (7511), 616-620, 2014 | 824 | 2014 |
| Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors J Zhang, FJ Adrián, W Jahnke, SW Cowan-Jacob, AG Li, RE Iacob, T Sim, ... Nature 463 (7280), 501-506, 2010 | 677 | 2010 |
| Allosteric inhibitors of Bcr-abl–dependent cell proliferation FJ Adrián, Q Ding, T Sim, A Velentza, C Sloan, Y Liu, G Zhang, W Hur, ... Nature chemical biology 2 (2), 95-102, 2006 | 467 | 2006 |
| Discovery of potent and selective covalent inhibitors of JNK T Zhang, F Inesta-Vaquera, M Niepel, J Zhang, SB Ficarro, T Machleidt, ... Chemistry & biology 19 (1), 140-154, 2012 | 353 | 2012 |
| Therapeutic targeting of oncogenic K‐Ras by a covalent catalytic site inhibitor SM Lim, KD Westover, SB Ficarro, RA Harrison, HG Choi, ME Pacold, ... Angewandte Chemie International Edition 53 (1), 199-204, 2014 | 345 | 2014 |
| Discovery of 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a Highly Potent, Selective … Q Liu, JW Chang, J Wang, SA Kang, CC Thoreen, A Markhard, W Hur, ... Journal of medicinal chemistry 53 (19), 7146-7155, 2010 | 278 | 2010 |
| Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function N Kwiatkowski, N Jelluma, P Filippakopoulos, M Soundararajan, ... Nature chemical biology 6 (5), 359-368, 2010 | 256 | 2010 |
| Test systems for harmonics modeling and simulation R Abu-Hashim, R Burch, G Chang, M Grady, E Gunther, M Halpin, ... IEEE Transactions on Power Delivery 14 (2), 579-587, 1999 | 208 | 1999 |
| Pharmacological targeting of the pseudokinase Her3 T Xie, SM Lim, KD Westover, ME Dodge, D Ercan, SB Ficarro, ... Nature chemical biology 10 (12), 1006-1012, 2014 | 202 | 2014 |
| A general strategy for creating “inactive-conformation” abl inhibitors B Okram, A Nagle, FJ Adrián, C Lee, P Ren, X Wang, T Sim, Y Xie, ... Chemistry & biology 13 (7), 779-786, 2006 | 202 | 2006 |
| Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors L Tan, J Wang, J Tanizaki, Z Huang, AR Aref, M Rusan, SJ Zhu, Y Zhang, ... Proceedings of the National Academy of Sciences 111 (45), E4869-E4877, 2014 | 188 | 2014 |
| Mapping the degradable kinome provides a resource for expedited degrader development KA Donovan, FM Ferguson, JW Bushman, NA Eleuteri, D Bhunia, SS Ryu, ... Cell 183 (6), 1714-1731. e10, 2020 | 169 | 2020 |
| Compounds and compositions as protein kinase inhibitors Q Ding, NS Gray, B Li, Y Liu, T Sim, T Uno, G Zhang, CP Soldermann, ... US Patent 8,552,002, 2013 | 166* | 2013 |
| Novel compounds and compositions as protein kinase inhibitors Q Ding, T Sim, G Zhang, F Adrian, N Gray US Patent App. 10/817,328, 2005 | 148 | 2005 |
| Acquired METD1228V Mutation and Resistance to MET Inhibition in Lung Cancer M Bahcall, T Sim, CP Paweletz, JD Patel, RS Alden, Y Kuang, AG Sacher, ... Cancer discovery 6 (12), 1334-1341, 2016 | 146 | 2016 |
| Compounds and compositions as protein kinase inhibitors P Ren, X Wang, G Zhang, Q Ding, S You, Q Zhang, G Chopiuk, ... US Patent 7,745,437, 2010 | 140 | 2010 |
| Tools for target identification and validation S Wang, TB Sim, YS Kim, YT Chang Current opinion in chemical biology 8 (4), 371-377, 2004 | 124 | 2004 |
| Efficient Synthesis of Enantiomerically Pure 2-Acylaziridines: Facile Syntheses of N-Boc-safingol, N-Boc-d-erythro-sphinganine, and N-Boc-spisulosine from a … JM Yun, TB Sim, HS Hahm, WK Lee, HJ Ha The Journal of organic chemistry 68 (20), 7675-7680, 2003 | 124 | 2003 |
| Development of a selective CDK7 covalent inhibitor reveals predominant cell-cycle phenotype CM Olson, Y Liang, A Leggett, WD Park, L Li, CE Mills, SZ Elsarrag, ... Cell chemical biology 26 (6), 792-803. e10, 2019 | 119 | 2019 |
