| Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants SCJ Parker, ML Stitzel, DL Taylor, JM Orozco, MR Erdos, JA Akiyama, ... Proceedings of the National Academy of Sciences 110 (44), 17921-17926, 2013 | 719* | 2013 |
| SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway X Gu, JM Orozco, RA Saxton, KJ Condon, GY Liu, PA Krawczyk, ... Science 358 (6364), 813-818, 2017 | 474 | 2017 |
| The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1 L Chantranupong, RL Wolfson, JM Orozco, RA Saxton, SM Scaria, ... Cell reports 9 (1), 1-8, 2014 | 452 | 2014 |
| KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1 RL Wolfson, L Chantranupong, GA Wyant, X Gu, JM Orozco, K Shen, ... Nature 543 (7645), 438-442, 2017 | 294 | 2017 |
| Dihydroxyacetone phosphate signals glucose availability to mTORC1 JM Orozco, PA Krawczyk, SM Scaria, AL Cangelosi, SH Chan, T Kunchok, ... Nature metabolism 2 (9), 893-901, 2020 | 158 | 2020 |
| Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction KJ Condon, JM Orozco, CH Adelmann, JB Spinelli, PW van der Helm, ... Proceedings of the National Academy of Sciences 118 (4), e2022120118, 2021 | 77 | 2021 |
| Filamin and Phospholipase C-ε Are Required for Calcium Signaling in the Caenorhabditis elegans Spermatheca I Kovacevic, JM Orozco, EJ Cram PLoS genetics 9 (5), e1003510, 2013 | 49 | 2013 |
| The methionine transamination pathway controls hepatic glucose metabolism through regulation of the GCN5 acetyltransferase and the PGC-1α transcriptional coactivator CDJ Tavares, K Sharabi, JE Dominy, Y Lee, M Isasa, JM Orozco, ... Journal of Biological Chemistry 291 (20), 10635-10645, 2016 | 42 | 2016 |
| Methods of identifying modulators of sestrin-gator-2 interaction for modulating mTORC1 activity DM Sabatini, L Chantranupong, RL Wolfson, J Orozco, RA Saxton, ... US Patent 10,168,338, 2019 | 3 | 2019 |
| Methods of identifying modulators of SAMTOR-GATOR1 interaction and use of same to modulate mTORC1 DM Sabatini, X Gu, JM Orozco US Patent 11,499,981, 2022 | | 2022 |
| Signal transduction in human cells by metabolites derived from methionine and glucose JM Orozco Massachusetts Institute of Technology, 2021 | | 2021 |
David M. SabatiniInstitute of Organic Chemistry and Biochemistry of the CASVerified email at uochb.cas.cz
