Transcription factors activate genes through the phase-separation capacity of their activation domains A Boija, IA Klein, BR Sabari, A Dall’Agnese, EL Coffey, AV Zamudio, ... Cell 175 (7), 1842-1855. e16, 2018 | 1346 | 2018 |
Pol II phosphorylation regulates a switch between transcriptional and splicing condensates YE Guo, JC Manteiga, JE Henninger, BR Sabari, A Dall’Agnese, ... Nature 572 (7770), 543-548, 2019 | 514 | 2019 |
Partitioning of cancer therapeutics in nuclear condensates IA Klein, A Boija, LK Afeyan, SW Hawken, M Fan, A Dall'Agnese, O Oksuz, ... Science 368 (6497), 1386-1392, 2020 | 324 | 2020 |
Mediator condensates localize signaling factors to key cell identity genes AV Zamudio, A Dall’Agnese, JE Henninger, JC Manteiga, LK Afeyan, ... Molecular cell 76 (5), 753-766. e6, 2019 | 203 | 2019 |
MeCP2 links heterochromatin condensates and neurodevelopmental disease CH Li, EL Coffey, A Dall’Agnese, NM Hannett, X Tang, JE Henninger, ... Nature 586 (7829), 440-444, 2020 | 135 | 2020 |
Predicting master transcription factors from pan-cancer expression data J Reddy, MAS Fonseca, RI Corona, R Nameki, F Segato Dezem, IA Klein, ... Science advances 7 (48), eabf6123, 2021 | 43 | 2021 |
Genetic variation associated with condensate dysregulation in disease SF Banani, LK Afeyan, SW Hawken, JE Henninger, A Dall’Agnese, ... Developmental cell 57 (14), 1776-1788. e8, 2022 | 40 | 2022 |
High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases JL Bessen, LK Afeyan, V Dančík, LW Koblan, DB Thompson, C Leichner, ... Nature communications 10 (1), 1937, 2019 | 30 | 2019 |
The transcription factor PAX8 promotes angiogenesis in ovarian cancer through interaction with SOX17 D Chaves-Moreira, MA Mitchell, C Arruza, P Rawat, S Sidoli, R Nameki, ... Science signaling 15 (728), eabm2496, 2022 | 23 | 2022 |
Transcription factors activate genes through the phase-separation capacity of their activation domains IA Klein, BR Sabari, A Dall’Agnese, EL Coffey, AV Zamudio, JC Manteiga, ... Elsevier BV, 2018 | 9 | 2018 |
Partitioning of cancer therapeutics in nuclear condensates. I Klein, A Boija, L Afeyan, S Hawken, M Fan, D Taatjes, A Chakraborty, ... Journal of Clinical Oncology 39 (15_suppl), 3131-3131, 2021 | 2 | 2021 |
Researcher Page IA Klein, A Boija, LK Afeyan Science 368 (6497), 1386-1392, 2020 | 2 | 2020 |
Methods and assays for modulating gene transcription by modulating condensates RA Young, PA Sharp, AK Chakraborty, A Dall'Agnese, K Shrinivas, ... US Patent App. 17/040,967, 2022 | 1 | 2022 |
Transcriptional and splicing condensates YE Guo, JC Manteiga, JE Henninger, BR Sabari, AD Agnese, K Shrinivas, ... | 1 | 2019 |
Chemical codes promote selective compartmentalization of proteins H Kilgore, I Chinn, P Mikhael, I Mitnikov, C Van Dongen, G Zylberberg, ... bioRxiv, 2024.04. 15.589616, 2024 | | 2024 |
Insights from biomolecular condensates into disease and drug development LK Afeyan Massachusetts Institute of Technology, 2022 | | 2022 |
Abstract GS3-10: Partitioning of cancer therapeutics in nuclear condensates I Klein, A Boija, L Afeyan, SW Hawken, M Fan, A Dall'Agnese, O Oksuz, ... Cancer Research 81 (4_Supplement), GS3-10-GS3-10, 2021 | | 2021 |
Systematic approaches to predict oncogenic transcriptional regulatory circuitries identify important nodes in high-grade serous ovarian cancer BJ Abraham, J Reddy, MA Fonseca, IA Klein, LK Afeyan, RI Corona, ... Cancer Research 79 (13_Supplement), 2615-2615, 2019 | | 2019 |
Mediator Condensates Localize Signaling Factors to Key Cell Identity Genes A Zamudio Montes de Oca, A Dall’Agnese, JE Henninger, JC Manteiga, ... Elsevier BV, 2019 | | 2019 |
Genetic Variation Associated with Condensate Dysregulation in SF Banani, LK Afeyan, SW Hawken, JE Henninger, A Dall’Agnese, ... | | |