|The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder|
GS Stewart, RS Maser, T Stankovic, DA Bressan, MI Kaplan, NGJ Jaspers, ...
Cell 99 (6), 577-587, 1999
|MDC1 is a mediator of the mammalian DNA damage checkpoint|
GS Stewart, B Wang, CR Bignell, AMR Taylor, SJ Elledge
Nature 421 (6926), 961-966, 2003
|The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage|
GS Stewart, S Panier, K Townsend, AK Al-Hakim, NK Kolas, ES Miller, ...
Cell 136 (3), 420-434, 2009
|Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia|
T Stankovic, P Weber, G Stewart, T Bedenham, J Murray, PJ Byrd, ...
The Lancet 353 (9146), 26-29, 1999
|53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair|
AT Noon, A Shibata, N Rief, M Löbrich, GS Stewart, PA Jeggo, ...
Nature cell biology 12 (2), 177-184, 2010
|p53 dysfunction in B-cell chronic lymphocytic leukemia: inactivation of ATM as an alternative toTP53 mutation|
AR Pettitt, PD Sherrington, G Stewart, JC Cawley, AMR Taylor, ...
Blood, The Journal of the American Society of Hematology 98 (3), 814-822, 2001
|Constitutive phosphorylation of MDC1 physically links the MRE11–RAD50–NBS1 complex to damaged chromatin|
C Spycher, ES Miller, K Townsend, L Pavic, NA Morrice, P Janscak, ...
The Journal of cell biology 181 (2), 227-240, 2008
|A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses|
CE Lilley, MS Chaurushiya, C Boutell, S Landry, J Suh, S Panier, ...
The EMBO journal 29 (5), 943-955, 2010
|Ataxia telangiectasia mutated–deficient B-cell chronic lymphocytic leukemia occurs in pregerminal center cells and results in defective damage response and unrepaired …|
T Stankovic, GS Stewart, C Fegan, P Biggs, J Last, PJ Byrd, RD Keenan, ...
Blood, The Journal of the American Society of Hematology 99 (1), 300-309, 2002
|RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling|
GS Stewart, T Stankovic, PJ Byrd, T Wechsler, ES Miller, A Huissoon, ...
Proceedings of the National Academy of Sciences 104 (43), 16910-16915, 2007
|Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation|
SY Lin, K Li, GS Stewart, SJ Elledge
Proceedings of the National Academy of Sciences 101 (17), 6484-6489, 2004
|ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53-or ATM-defective chronic lymphocytic leukemia cells|
M Kwok, N Davies, A Agathanggelou, E Smith, C Oldreive, E Petermann, ...
Blood 127 (5), 582-595, 2016
|Regulation of DNA-end resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair|
SE Polo, AN Blackford, JR Chapman, L Baskcomb, S Gravel, A Rusch, ...
Molecular cell 45 (4), 505-516, 2012
|Microarray analysis reveals that TP53-and ATM-mutant B-CLLs share a defect in activating proapoptotic responses after DNA damage but are distinguished by major differences in …|
T Stankovic, M Hubank, D Cronin, GS Stewart, D Fletcher, CR Bignell, ...
Blood 103 (1), 291-300, 2004
|The hMsh2-hMsh6 complex acts in concert with monoubiquitinated PCNA and Pol η in response to oxidative DNA damage in human cells|
A Zlatanou, E Despras, T Braz-Petta, I Boubakour-Azzouz, C Pouvelle, ...
Molecular cell 43 (4), 649-662, 2011
|The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression|
AS Turnell, GS Stewart, RJA Grand, SM Rookes, A Martin, H Yamano, ...
Nature 438 (7068), 690-695, 2005
|BOD1L is required to suppress deleterious resection of stressed replication forks|
MR Higgs, JJ Reynolds, A Winczura, AN Blackford, V Borel, ES Miller, ...
Molecular cell 59 (3), 462-477, 2015
|ATM mutations in sporadic lymphoid tumours|
T Stankovic, GS Stewart, P Byrd, C Fegan, PAH Moss, AMR Taylor
Leukemia & lymphoma 43 (8), 1563-1571, 2002
|Residual ataxia telangiectasia mutated protein function in cells from ataxia telangiectasia patients, with 5762ins137 and 7271T→ G mutations, showing a less severe phenotype|
GS Stewart, JIK Last, T Stankovic, N Haites, AMJ Kidd, PJ Byrd, ...
Journal of Biological Chemistry 276 (32), 30133-30141, 2001
|Identification of the first ATRIP–deficient patient and novel mutations in ATR define a clinical spectrum for ATR–ATRIP Seckel syndrome|
T Ogi, S Walker, T Stiff, E Hobson, S Limsirichaikul, G Carpenter, ...
PLoS Genet 8 (11), e1002945, 2012